7SH0

CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE

Summary for 7SH0

• Entry DOI: 10.2210/pdb7sh0/pdb
• Descriptor: Endoplasmic reticulum aminopeptidase 2, ZINC ION, (2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide, ... (7 entities in total)
• Functional Keywords: aminopeptidase, erap2 structure, enzyme inhibitor, antigen processing, immune system, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 225329.06

Authors

Li, L.,Bouvier, M. (deposition date: 2021-10-07, release date: 2022-07-20, Last modification date: 2023-10-25)

• Primary citation: Camberlein, V.,Fleau, C.,Sierocki, P.,Li, L.,Gealageas, R.,Bosc, D.,Guillaume, V.,Warenghem, S.,Leroux, F.,Rosell, M.,Cheng, K.,Medve, L.,Prigent, M.,Decanter, M.,Piveteau, C.,Biela, A.,Eveque, M.,Dumont, J.,Mpakali, A.,Giastas, P.,Herledan, A.,Couturier, C.,Haupenthal, J.,Lesire, L.,Hirsch, A.K.H.,Deprez, B.,Stratikos, E.,Bouvier, M.,Deprez-Poulain, R.; Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis.; Angew.Chem.Int.Ed.Engl., 61:e202203560-e202203560, 2022; PubMed: 35904863; DOI: 10.1002/anie.202203560

Experimental method

X-RAY DIFFRACTION (3.2 Å)