1LVU
 
 | | Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit | | Descriptor: | 2,6-DIAMINO-(S)-9-[2-(PHOSPHONOMETHOXY)PROPYL]PURINE, CALCIUM ION, Purine nucleoside phosphorylase | | Authors: | Bzowska, A, Koellner, G, Wielgus-Kutrowska, B, Stroh, A, Raszewski, G, Holy, A, Steiner, T, Frank, J. | | Deposit date: | 2002-05-29 | | Release date: | 2003-09-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis
J.Mol.Biol., 342, 2004
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1LV8
 | | Crystal structure of calf spleen purine nucleoside phosphorylase in a new space group with full trimer in the asymmetric unit | | Descriptor: | 2,6-DIAMINO-(S)-9-[2-(PHOSPHONOMETHOXY)PROPYL]PURINE, CALCIUM ION, PURINE NUCLEOSIDE PHOSPHORYLASE | | Authors: | Bzowska, A, Koellner, G, Wielgus-Kutrowska, B, Stroh, A, Raszewski, G, Holy, A, Steiner, T, Frank, J. | | Deposit date: | 2002-05-27 | | Release date: | 2003-09-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of calf spleen purine nucleoside phosphorylase with two full trimers in the asymmetric unit: important implications for the mechanism of catalysis
J.Mol.Biol., 342, 2004
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8QWA
 | | Adenylosuccinate Synthetase from H. pylori in complex with PLP and IMP | | Descriptor: | Adenylosuccinate synthetase, GLYCEROL, INOSINIC ACID, ... | | Authors: | Bzowska, A, Narczyk, M, Maksymiuk, W. | | Deposit date: | 2023-10-19 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains.
J Enzyme Inhib Med Chem, 39, 2024
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7PVO
 | | Adenylosuccinate Synthetase from H. pylori in complex with IMP | | Descriptor: | Adenylosuccinate synthetase, INOSINIC ACID, SULFATE ION | | Authors: | Narczyk, M, Bzowska, A, Maksymiuk, W. | | Deposit date: | 2021-10-05 | | Release date: | 2022-11-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site.
Int.J.Biol.Macromol., 226, 2023
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6XZ2
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1FXU
 | | PURINE NUCLEOSIDE PHOSPHORYLASE FROM CALF SPLEEN IN COMPLEX WITH N(7)-ACYCLOGUANOSINE INHIBITOR AND A PHOSPHATE ION | | Descriptor: | 2-AMINO-7-[2-(2-HYDROXY-1-HYDROXYMETHYL-ETHYLAMINO)-ETHYL]-1,7-DIHYDRO-PURIN-6-ONE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Luic, M, Bzowska, A, Shugar, D, Saenger, W, Koellner, G. | | Deposit date: | 2000-09-27 | | Release date: | 2000-10-18 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion.
Acta Crystallogr.,Sect.D, 57, 2001
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3FUC
 | | Recombinant calf purine nucleoside phosphorylase in a binary complex with multisubstrate analogue inhibitor 9-(5',5'-difluoro-5'-phosphonopentyl)-9-deazaguanine structure in a new space group with one full trimer in the asymmetric unit | | Descriptor: | AZIDE ION, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | | Authors: | Bochtler, M, Breer, K, Bzowska, A, Chojnowski, G, Hashimoto, M, Hikishima, S, Narczyk, M, Wielgus-Kutrowska, B, Yokomatsu, T. | | Deposit date: | 2009-01-14 | | Release date: | 2009-12-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | 1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Biochem.Biophys.Res.Commun., 391, 2010
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1VFN
 | | PURINE NUCLEOSIDE PHOSPHORYLASE | | Descriptor: | HYPOXANTHINE, MAGNESIUM ION, PURINE-NUCLEOSIDE PHOSPHORYLASE, ... | | Authors: | Koellner, G, Bzowska, A. | | Deposit date: | 1996-10-08 | | Release date: | 1997-11-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of calf spleen purine nucleoside phosphorylase in a complex with hypoxanthine at 2.15 A resolution.
J.Mol.Biol., 265, 1997
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1K9S
 | | PURINE NUCLEOSIDE PHOSPHORYLASE FROM E. COLI IN COMPLEX WITH FORMYCIN A DERIVATIVE AND PHOSPHATE | | Descriptor: | 2-(7-AMINO-6-METHYL-3H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, 2-HYDROXYMETHYL-5-(7-METHYLAMINO-3H-PYRAZOLO[4,3-D]PYRIMIDIN-3-YL)-TETRAHYDRO-FURAN-3,4-DIOL, PHOSPHATE ION, ... | | Authors: | Koellner, G, Bzowska, A, Wielgus-Kutrowska, B, Luic, M, Steiner, T, Saenger, W, Stepinski, J. | | Deposit date: | 2001-10-30 | | Release date: | 2001-11-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism.
J.Mol.Biol., 315, 2002
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1A69
 | | PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX WITH FORMYCIN B AND SULPHATE (PHOSPHATE) | | Descriptor: | FORMYCIN B, PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION | | Authors: | Koellner, G, Luic, M, Shugar, D, Saenger, W, Bzowska, A. | | Deposit date: | 1998-03-08 | | Release date: | 1998-10-14 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of the ternary complex of E. coli purine nucleoside phosphorylase with formycin B, a structural analogue of the substrate inosine, and phosphate (Sulphate) at 2.1 A resolution.
J.Mol.Biol., 280, 1998
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1C3X
 | | PURINE NUCLEOSIDE PHOSPHORYLASE FROM CELLULOMONAS SP. IN COMPLEX WITH 8-IODO-GUANINE | | Descriptor: | 8-IODO-GUANINE, CALCIUM ION, PENTOSYLTRANSFERASE, ... | | Authors: | Tebbe, J, Bzowska, A, Wielgus-Kutrowska, B, Schroeder, W, Kazimierczuk, Z, Shugar, D, Saenger, W, Koellner, G. | | Deposit date: | 1999-07-29 | | Release date: | 1999-12-22 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
J.Mol.Biol., 294, 1999
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1V48
 | | Calf spleen purine nucleoside phosphorylase (PNP) binary complex with 9-(5,5-difluoro-5-phosphonopenthyl)guanine | | Descriptor: | 9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE, MAGNESIUM ION, Purine nucleoside phosphorylase, ... | | Authors: | Luic, M, Koellner, G, Yokomatsu, T, Shibuya, S, Bzowska, A. | | Deposit date: | 2003-11-11 | | Release date: | 2004-08-03 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Calf spleen purine-nucleoside phosphorylase: crystal structure of the binary complex with a potent multisubstrate analogue inhibitor.
Acta Crystallogr.,Sect.D, 60, 2004
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1QE5
 | | PURINE NUCLEOSIDE PHOSPHORYLASE FROM CELLULOMONAS SP. IN COMPLEX WITH PHOSPHATE | | Descriptor: | CALCIUM ION, PENTOSYLTRANSFERASE, PHOSPHATE ION | | Authors: | Tebbe, J, Bzowska, A, Wielgus-Kutrowska, B, Schroeder, W, Kazimierczuk, Z, Shugar, D, Saenger, W, Koellner, G. | | Deposit date: | 1999-07-13 | | Release date: | 1999-12-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
J.Mol.Biol., 294, 1999
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4TS9
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4TTJ
 | | Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 6 FMC molecules | | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | | Authors: | Stefanic, Z, Bzowska, A. | | Deposit date: | 2014-06-21 | | Release date: | 2015-07-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.874 Å) | | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis.
Sci Rep, 8, 2018
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4TTA
 | | Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 2 FMC molecules | | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | | Authors: | Stefanic, Z, Bzowska, A. | | Deposit date: | 2014-06-20 | | Release date: | 2015-07-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis.
Sci Rep, 8, 2018
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4TTI
 | | Crystal structure of double mutant E. Coli purine nucleoside phosphorylase with 4 FMC molecules | | Descriptor: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, PHOSPHATE ION, Purine nucleoside phosphorylase DeoD-type, ... | | Authors: | Stefanic, Z, Bzowska, A. | | Deposit date: | 2014-06-21 | | Release date: | 2015-07-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystallographic snapshots of ligand binding to hexameric purine nucleoside phosphorylase and kinetic studies give insight into the mechanism of catalysis.
Sci Rep, 8, 2018
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4TS3
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3OOE
 | | Crystal structure of E. Coli purine nucleoside phosphorylase with PO4 | | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | | Deposit date: | 2010-08-31 | | Release date: | 2011-07-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie, 93, 2011
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3ONV
 | | Crystal structure of E. Coli purine nucleoside phosphorylase with SO4 | | Descriptor: | Purine nucleoside phosphorylase deoD-type, SULFATE ION | | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | | Deposit date: | 2010-08-30 | | Release date: | 2011-07-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.893 Å) | | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie, 93, 2011
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3OPV
 | | Crystal structure of E. Coli purine nucleoside phosphorylase Arg24Ala mutant | | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | | Deposit date: | 2010-09-02 | | Release date: | 2011-07-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie, 93, 2011
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3OOH
 | | Crystal structure of E. Coli purine nucleoside phosphorylase with PO4 | | Descriptor: | PHOSPHATE ION, Purine nucleoside phosphorylase deoD-type | | Authors: | Mikleusevic, G, Stefanic, Z, Narzyk, M, Wielgus-Kutrowska, B, Bzowska, A, Luic, M. | | Deposit date: | 2010-08-31 | | Release date: | 2011-07-13 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Validation of the catalytic mechanism of Escherichia coli purine nucleoside phosphorylase by structural and kinetic studies.
Biochimie, 93, 2011
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5M4Z
 | | Crystal structure of the complex of T.spiralis thymidylate synthase with N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate, crystallized in the presence of N(5,10)-methylenetetrahydrofolate | | Descriptor: | GLYCEROL, Thymidylate synthase, [(2~{R},3~{S},5~{R})-5-[(4~{E})-4-hydroxyimino-2-oxidanylidene-1,3-diazinan-1-yl]-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | | Authors: | Wilk, P, Maj, P, Jarmula, A, Dowiercial, A, Rode, W. | | Deposit date: | 2016-10-19 | | Release date: | 2017-12-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.179 Å) | | Cite: | Molecular Mechanism of Thymidylate Synthase Inhibition by N 4 -Hydroxy-dCMP in View of Spectrophotometric and Crystallographic Studies.
Int J Mol Sci, 22, 2021
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9F17
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6ZXQ
 | | Adenylosuccinate Synthetase from H. pylori in complex with HDA, GDP, IMO, Mg | | Descriptor: | 6-O-PHOSPHORYL INOSINE MONOPHOSPHATE, Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Bubic, A, Stefanic, Z. | | Deposit date: | 2020-07-30 | | Release date: | 2021-08-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The pursuit of new alternative ways to eradicate Helicobacter pylori continues: Detailed characterization of interactions in the adenylosuccinate synthetase active site
Int.J.Biol.Macromol., 2023
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