2IWI | | CRYSTAL STRUCTURE OF THE HUMAN PIM2 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU1 | | Descriptor: | SERINE/THREONINE-PROTEIN KINASE PIM-2, RUTHENIUM-PYRIDOCARBAZOLE-1 | | Authors: | Russo, S., Debreczeni, J.E., Amos, A., Bullock, A.N., Fedorov, O., Niesen, F., Sobott, F., Turnbull, A., Pike, A.C.W., Ugochukwu, E., Papagrigoriou, E., Bunkoczi, G., Gorrec, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., von Delft, F., Knapp, S. | | Deposit date: | 2006-06-30 | | Release date: | 2006-08-02 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.
PLoS ONE, 4, 2009
|
|
1UJZ | | CRYSTAL STRUCTURE OF THE E7_C/IM7_C COMPLEX; A COMPUTATIONALLY DESIGNED INTERFACE BETWEEN THE COLICIN E7 DNASE AND THE IM7 IMMUNITY PROTEIN | | Descriptor: | Designed Colicin E7 immunity protein, Designed Colicin E7 DNase | | Authors: | Kortemme, T., Joachimiak, L.A., Bullock, A.N., Schuler, A.D., Stoddard, B.L., Baker, D. | | Deposit date: | 2003-08-13 | | Release date: | 2004-04-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Computational redesign of protein-protein interaction specificity
NAT.STRUCT.MOL.BIOL., 11, 2004
|
|
2IVX | | CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION | | Descriptor: | CYCLIN-T2, 1,2-ETHANEDIOL | | Authors: | Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S. | | Deposit date: | 2006-06-21 | | Release date: | 2006-07-19 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
|
|
2J2I | | CRYSTAL STRUCTURE OF THE HUMAB PIM1 IN COMPLEX WITH LY333531 | | Descriptor: | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION, (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIAZACYCLOHEXADECINE-18,20-DIONE | | Authors: | Debreczeni, J.E., Bullock, A.N., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S. | | Deposit date: | 2006-08-16 | | Release date: | 2007-02-13 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U.S.A., 104, 2007
|
|
2VAG | | CRYSTAL STRUCTURE OF DI-PHOSPHORYLATED HUMAN CLK1 IN COMPLEX WITH A NOVEL SUBSTITUTED INDOLE INHIBITOR | | Descriptor: | DUAL SPECIFICITY PROTEIN KINASE CLK1, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate | | Authors: | Pike, A.C.W., Bullock, A.N., Fedorov, O., Pilka, E.S., Ugochukwu, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Huber, K., Bracher, F., Knapp, S. | | Deposit date: | 2007-08-31 | | Release date: | 2007-10-09 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
|
|
2VPJ | | CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL12 | | Descriptor: | KELCH-LIKE PROTEIN 12, ACETATE ION | | Authors: | Keates, T., Pike, A.C.W., Bullock, A.N., Salah, E., Filippakopoulos, P., Roos, A.K., von Delft, F., Savitsky, P., Weigelt, J., Edwards, A., Arrowsmith, C.H., Bountra, C., Knapp, S. | | Deposit date: | 2008-02-29 | | Release date: | 2008-03-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
2WU6 | | CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH DKI | | Descriptor: | DUAL SPECIFICITY PROTEIN KINASE CLK3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION, ... | | Authors: | Muniz, J.R.C., Fedorov, O., King, O., Filippakopoulos, P., Bullock, A.N., Philips, C., Heightman, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S. | | Deposit date: | 2009-09-30 | | Release date: | 2009-10-20 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
|
|
2WU7 | | CRYSTAL STRUCTURE OF THE HUMAN CLK3 IN COMPLEX WITH V25 | | Descriptor: | DUAL SPECIFICITY PROTEIN KINASE CLK3, ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, SULFATE ION, ... | | Authors: | Muniz, J.R.C., Fedorov, O., King, O., Filippakopoulos, P., Bullock, A.N., Phillips, C., Heightman, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Bracher, F., Huber, K., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S. | | Deposit date: | 2009-09-30 | | Release date: | 2009-10-20 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Specific Clk Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing.
Chem.Biol, 18, 2011
|
|
2WZK | | STRUCTURE OF THE CUL5 N-TERMINAL DOMAIN AT 2.05A RESOLUTION. | | Descriptor: | CULLIN-5, 1,2-ETHANEDIOL | | Authors: | Muniz, J.R.C., Ayinampudi, V., Zhang, Y., Babon, J.J., Chaikuad, A., Krojer, T., Pike, A.C.W., Vollmar, M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Bullock, A.N. | | Deposit date: | 2009-11-30 | | Release date: | 2009-12-15 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases
J.Mol.Biol., 425, 2013
|
|
2XN4 | | CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KLHL2 (MAYVEN) | | Descriptor: | KELCH-LIKE PROTEIN 2, SODIUM ION, SULFATE ION, ... | | Authors: | Canning, P., Hozjan, V., Cooper, C.D.O., Ayinampudi, V., Vollmar, M., Pike, A.C.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N. | | Deposit date: | 2010-07-30 | | Release date: | 2010-08-18 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
2XVS | | CRYSTAL STRUCTURE OF HUMAN TTC5 (STRAP) C-TERMINAL OB DOMAIN | | Descriptor: | TETRATRICOPEPTIDE REPEAT PROTEIN 5, IODIDE ION, 1,2-ETHANEDIOL, ... | | Authors: | Adams, J., Pike, A.C.W., Maniam, S., Sharpe, T.D., Coutts, A.S., Knapp, S., La Thangue, B., Bullock, A.N. | | Deposit date: | 2010-10-31 | | Release date: | 2010-11-17 | | Last modified: | 2012-03-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The P53 Cofactor Strap Exhibits an Unexpected Tpr Motif and Oligonucleotide-Binding (Ob)-Fold Structure.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
2XWC | | CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TP73 REFINED AT 1.8 A RESOLUTION | | Descriptor: | TUMOUR PROTEIN P73, ZINC ION, TRIS(HYDROXYETHYL)AMINOMETHANE, ... | | Authors: | Canning, P., Zhang, Y., Vollmar, M., Krojer, T., Ugochukwu, E., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N. | | Deposit date: | 2010-11-03 | | Release date: | 2010-11-17 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73.
J.Mol.Biol., 423, 2012
|
|
3JPV | | CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A PYRROLO[2,3-A]CARBAZOLE LIGAND | | Descriptor: | Proto-oncogene serine/threonine-protein kinase Pim-1, Peptide (PIMTIDE) ARKRRRHPSGPPTA, 1,10-dihydropyrrolo[2,3-a]carbazole-3-carbaldehyde | | Authors: | Filippakopoulos, P., Bullock, A.N., Fedorov, O., Akue-Gedu, R., Rossignol, E., Azzaro, S., Bain, J., Cohen, P., Prudhomme, M., Moreau, P., Amizon, F., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-09-04 | | Release date: | 2009-10-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new pim kinase inhibitors.
J.Med.Chem., 52, 2009
|
|
3QF9 | | CRYSTAL STRUCTURE OF HUMAN PROTO-ONCOGENE SERINE THREONINE KINASE (PIM1) IN COMPLEX WITH A CONSENSUS PEPTIDE AND A FURAN-THIAZOLIDINEDIONE LIGAND | | Descriptor: | Proto-oncogene serine/threonine-protein kinase pim-1, pimtide, 6-{5-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}naphthalene-1-carboxamide, ... | | Authors: | Filippakopoulos, P., Bullock, A.N., Fedorov, O., Miduturu, C.V., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Grey, N., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2011-01-21 | | Release date: | 2011-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a furan-thiazolidinedione ligand
To be Published
|
|
3ZKJ | | CRYSTAL STRUCTURE OF ANKYRIN REPEAT AND SOCS BOX-CONTAINING PROTEIN 9 (ASB9) IN COMPLEX WITH ELONGINB AND ELONGINC | | Descriptor: | ANKYRIN REPEAT AND SOCS BOX PROTEIN 9, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, ... | | Authors: | Muniz, J.R.C., Guo, K., Zhang, Y., Ayinampudi, V., Savitsky, P., Keates, T., Filippakopoulos, P., Vollmar, M., Yue, W.W., Krojer, T., Ugochukwu, E., von Delft, F., Knapp, S., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N. | | Deposit date: | 2013-01-23 | | Release date: | 2013-01-30 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Molecular Architecture of the Ankyrin Socs Box Family of Cul5-Dependent E3 Ubiquitin Ligases
J.Mol.Biol., 425, 2013
|
|
4A63 | | CRYSTAL STRUCTURE OF THE P73-ASPP2 COMPLEX AT 2.6A RESOLUTION | | Descriptor: | TUMOUR PROTEIN 73, APOPTOSIS STIMULATING OF P53 PROTEIN 2, ZINC ION, ... | | Authors: | Canning, P., Sharpe, T., Krojer, T., Savitsky, P., Cooper, C.D.O., Salah, E., Keates, T., Muniz, J., Vollmar, M., von Delft, F., Weigelt, J., Arrowsmith, C., Bountra, C., Edwards, A., Bullock, A.N. | | Deposit date: | 2011-10-31 | | Release date: | 2011-12-21 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Structural Basis for Aspp2 Recognition by the Tumor Suppressor P73.
J.Mol.Biol., 423, 2012
|
|
4ABN | | CRYSTAL STRUCTURE OF FULL LENGTH MOUSE STRAP (TTC5) | | Descriptor: | TETRATRICOPEPTIDE REPEAT PROTEIN 5, 1,2-ETHANEDIOL | | Authors: | Pike, A.C.W., Bullock, A.N., Kleinekofort, W., Zimmermann, T., Burgess-Brown, N., Sharpe, T.D., Thangaratnarajah, C., Keates, T., Ugochukwu, E., Bunkoczi, G., Uppenberg, J., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., La Thangue, N.B., Knapp, S. | | Deposit date: | 2011-12-09 | | Release date: | 2012-01-25 | | Last modified: | 2012-03-21 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The P53 Cofactor Strap Exhibits an Unexpected Tpr Motif and Oligonucleotide-Binding (Ob)-Fold Structure.
Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
4AP2 | | CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 2.8A RESOLUTION | | Descriptor: | KELCH-LIKE PROTEIN 11, CULLIN-3, 1,2-ETHANEDIOL, ... | | Authors: | Canning, P., Cooper, C.D.O., Krojer, T., Filippakopoulos, P., Ayinampudi, V., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-03-30 | | Release date: | 2012-05-09 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
4APF | | CRYSTAL STRUCTURE OF THE HUMAN KLHL11-CUL3 COMPLEX AT 3.1A RESOLUTION | | Descriptor: | KELCH-LIKE PROTEIN 11, CULLIN 3 | | Authors: | Canning, P., Cooper, C.D.O., Krojer, T., Vollmar, M., Ugochukwu, E., Muniz, J.R.C., Ayinampudi, V., Savitsky, P., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Bullock, A.N., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-04-02 | | Release date: | 2012-05-09 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
4ASC | | CRYSTAL STRUCTURE OF THE KELCH DOMAIN OF HUMAN KBTBD5 | | Descriptor: | KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5, 1,2-ETHANEDIOL | | Authors: | Canning, P., Ayinampudi, V., Krojer, T., Strain-Damerell, C., Raynor, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Structural Genomics Consortium (SGC) | | Deposit date: | 2012-04-30 | | Release date: | 2012-05-09 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases.
J.Biol.Chem., 288, 2013
|
|
4AYT | | STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 | | Descriptor: | ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10 MITOCHONDRIAL, GLYCINE, MAGNESIUM ION, ... | | Authors: | Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P. | | Deposit date: | 2012-06-22 | | Release date: | 2012-07-11 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4AYW | | STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM) | | Descriptor: | ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ... | | Authors: | Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P. | | Deposit date: | 2012-06-22 | | Release date: | 2012-07-11 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4AYX | | STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (ROD FORM B) | | Descriptor: | ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, GLYCINE, MAGNESIUM ION, ... | | Authors: | Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P. | | Deposit date: | 2012-06-22 | | Release date: | 2012-07-11 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
5L6W | | STRUCTURE OF THE LIMK1-ATPGAMMAS-CFL1 COMPLEX | | Descriptor: | LIM domain kinase 1, Cofilin-1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Salah, E., Mathea, S., Oerum, S., Newman, J.A., Tallant, C., Adamson, R., Canning, P., Beltrami, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Bullock, A.N. | | Deposit date: | 2016-05-31 | | Release date: | 2016-06-08 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Structure Of the LIMK1-ATPgammaS-CFL1 Complex
To Be Published
|
|
5NXC | | LIM DOMAIN KINASE 1 (LIMK1) IN COMPLEX WITH PF-00477736 | | Descriptor: | LIM domain kinase 1, (2~{R})-2-azanyl-2-cyclohexyl-~{N}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide | | Authors: | Mathea, S., Salah, E., Pike, A.C.W., Bushell, S., Carpenter, E.P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.N., Knapp, S. | | Deposit date: | 2017-05-10 | | Release date: | 2017-05-24 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | LIM Domain Kinase (LIMK1) In Complex With PF-00477736
To Be Published
|
|
