Author results

1GY5
  • Download 1gy5
  • View 1gy5
Molmil generated image of 1gy5
D92N,D94N DOUBLE POINT MUTANT OF HUMAN NUCLEAR TRANSPORT FACTOR 2 (NTF2)
Descriptor:NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R., Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GY6
  • Download 1gy6
  • View 1gy6
Molmil generated image of 1gy6
NTF2 FROM RAT, AMMONIUM SULPHATE CONDITIONS
Descriptor:NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R., Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GY7
  • Download 1gy7
  • View 1gy7
Molmil generated image of 1gy7
N77Y POINT MUTANT OF S.CEREVISIAE NTF2
Descriptor:NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R., Quimby, B.B., Corbett, A., Stewart, M.
Deposit date:2002-04-21
Release date:2002-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1GYB
  • Download 1gyb
  • View 1gyb
Molmil generated image of 1gyb
N77Y POINT MUTANT OF YNTF2 BOUND TO FXFG NUCLEOPORIN REPEAT
Descriptor:NUCLEAR TRANSPORT FACTOR 2, NUCLEOPORIN
Authors:Bayliss, R., Stewart, M.
Deposit date:2002-04-22
Release date:2002-06-20
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for the Interaction between Ntf2 and Nucleoporin Fxfg Repeats
Embo J., 21, 2002
1F59
  • Download 1f59
  • View 1f59
Molmil generated image of 1f59
IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX
Descriptor:IMPORTIN BETA-1, FXFG NUCLEOPORIN REPEATS
Authors:Bayliss, R., Littlewood, T., Stewart, M.
Deposit date:2000-06-13
Release date:2000-08-16
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
Cell(Cambridge,Mass.), 102, 2000
1O6O
  • Download 1o6o
  • View 1o6o
Molmil generated image of 1o6o
IMPORTIN BETA AA1-442 BOUND TO FIVE FXFG REPEATS FROM YEAST NSP1P. SECOND CRYSTAL FORM
Descriptor:IMPORTIN BETA-1 SUBUNIT, NUCLEOPORIN NSP1
Authors:Bayliss, R., Stewart, M.
Deposit date:2002-10-10
Release date:2003-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
1O6P
  • Download 1o6p
  • View 1o6p
Molmil generated image of 1o6p
IMPORTIN BETA BOUND TO A GLFG NUCLEOPORIN PEPTIDE
Descriptor:IMPORTIN BETA-1 SUBUNIT, SYNTHETIC GLFG PEPTIDE
Authors:Bayliss, R., Stewart, M.
Deposit date:2002-10-10
Release date:2003-04-24
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Glfg and Fxfg Nucleoporins Bind to Overlapping Sites on Importin-Beta
J.Biol.Chem., 277, 2002
1OL5
  • Download 1ol5
  • View 1ol5
Molmil generated image of 1ol5
STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43
Descriptor:SERINE/THREONINE KINASE 6, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Bayliss, R., Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1OL6
  • Download 1ol6
  • View 1ol6
Molmil generated image of 1ol6
STRUCTURE OF UNPHOSPHORYLATED D274N MUTANT OF AURORA-A
Descriptor:SERINE/THREONINE KINASE 6, ADENOSINE-5'-TRIPHOSPHATE
Authors:Bayliss, R., Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle.
Mol.Cell, 12, 2003
1OL7
  • Download 1ol7
  • View 1ol7
Molmil generated image of 1ol7
STRUCTURE OF HUMAN AURORA-A 122-403 PHOSPHORYLATED ON THR287, THR288
Descriptor:SERINE/THREONINE KINASE 6, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Bayliss, R., Conti, E.
Deposit date:2003-08-06
Release date:2003-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
1QMA
  • Download 1qma
  • View 1qma
Molmil generated image of 1qma
NUCLEAR TRANSPORT FACTOR 2 (NTF2) W7A MUTANT
Descriptor:NUCLEAR TRANSPORT FACTOR 2
Authors:Bayliss, R., Ribbeck, K., Akin, D., Kent, H.M., Feldherr, C.M., Gorlich, D., Stewart, M.J.
Deposit date:1999-09-23
Release date:2000-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interaction Betweeen Ntf2 and Xfxfg-Containing Nucleoporins is Required to Mediate Nuclear Import of Ran-Gdp
J.Mol.Biol., 293, 1999
2OFQ
  • Download 2ofq
  • View 2ofq
Molmil generated image of 2ofq
NMR SOLUTION STRUCTURE OF A COMPLEX BETWEEN THE VIRB9/VIRB7 INTERACTION DOMAINS OF THE PKM101 TYPE IV SECRETION SYSTEM
Descriptor:TraO, TraN
Authors:Harris, R., Bayliss, R., Driscoll, P.C., Waksman, G.
Deposit date:2007-01-04
Release date:2007-01-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system
Proc.Natl.Acad.Sci.Usa, 104, 2007
4Z7G
  • Download 4z7g
  • View 4z7g
Molmil generated image of 4z7g
CRYSTAL STRUCTURE OF HUMAN IRE1 CYTOPLASMIC KINASE-RNASE REGION - APO
Descriptor:Serine/threonine-protein kinase/endoribonuclease IRE1, SODIUM ION
Authors:Bayliss, R., Joshi, A.
Deposit date:2015-04-07
Release date:2015-05-27
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
Oncotarget, 6, 2015
6HV0
  • Download 6hv0
  • View 6hv0
Molmil generated image of 6hv0
IRE1 KINASE/RNASE IN COMPLEX WITH IMIDAZO[1,2-B]PYRIDAZIN-8-AMINE COMPOUND 33
Descriptor:Serine/threonine-protein kinase/endoribonuclease IRE1, 6-chloranyl-3-(2~{H}-indazol-5-yl)-~{N}-propan-2-yl-imidazo[1,2-b]pyridazin-8-amine
Authors:Bayliss, R., Bhatia, C., Collins, I.
Deposit date:2018-10-09
Release date:2019-02-27
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease.
J.Med.Chem., 62, 2019
6R49
  • Download 6r49
  • View 6r49
Molmil generated image of 6r49
AURORA-A IN COMPLEX WITH SHAPE-DIVERSE FRAGMENT 39
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bayliss, R., McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.209 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4A
  • Download 6r4a
  • View 6r4a
Molmil generated image of 6r4a
AURORA-A IN COMPLEX WITH SHAPE-DIVERSE FRAGMENT 55
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Bayliss, R., McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4B
  • Download 6r4b
  • View 6r4b
Molmil generated image of 6r4b
AURORA-A IN COMPLEX WITH SHAPE-DIVERSE FRAGMENT 56
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bayliss, R., McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4C
  • Download 6r4c
  • View 6r4c
Molmil generated image of 6r4c
AURORA-A IN COMPLEX WITH SHAPE-DIVERSE FRAGMENT 57
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bayliss, R., McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-01
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
6R4D
  • Download 6r4d
  • View 6r4d
Molmil generated image of 6r4d
AURORA-A IN COMPLEX WITH SHAPE-DIVERSE FRAGMENT 58
Descriptor:Aurora kinase A, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bayliss, R., McIntyre, P.J.
Deposit date:2019-03-22
Release date:2019-05-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Construction of a Shape-Diverse Fragment Set: Design, Synthesis and Screen against Aurora-A Kinase.
Chemistry, 25, 2019
2BHM
  • Download 2bhm
  • View 2bhm
Molmil generated image of 2bhm
CRYSTAL STRUCTURE OF VIRB8 FROM BRUCELLA SUIS
Descriptor:TYPE IV SECRETION SYSTEM PROTEIN VIRB8
Authors:Bayliss, R., Baron, C., Waksman, G.
Deposit date:2005-01-14
Release date:2005-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Two Core Subunits of the Bacterial Type Iv Secretion System, Virb8 from Brucella Suis and Comb10 from Helicobacter Pylori
Proc.Natl.Acad.Sci.USA, 102, 2005
2W5B
  • Download 2w5b
  • View 2w5b
Molmil generated image of 2w5b
HUMAN NEK2 KINASE ATPGAMMAS-BOUND
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, CHLORIDE ION, ...
Authors:Bayliss, R.
Deposit date:2008-12-08
Release date:2008-12-23
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights Into the Conformational Variability and Regulation of Human Nek2 Kinase.
J.Mol.Biol., 386, 2009
2W5H
  • Download 2w5h
  • View 2w5h
Molmil generated image of 2w5h
HUMAN NEK2 KINASE APO
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK2
Authors:Bayliss, R.
Deposit date:2008-12-10
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Insights Into the Conformational Variability and Regulation of Human Nek2 Kinase.
J.Mol.Biol., 386, 2009
5M51
  • Download 5m51
  • View 5m51
Molmil generated image of 5m51
NEK2 BOUND TO ARYLAMINOPURINE COMPOUND 8
Descriptor:Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-9~{H}-purin-2-yl]amino]benzamide
Authors:Bayliss, R., Yeoh, S.
Deposit date:2016-10-20
Release date:2016-11-09
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
5M53
  • Download 5m53
  • View 5m53
Molmil generated image of 5m53
NEK2 BOUND TO ARYLAMINOPURINE INHIBITOR 11
Descriptor:Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N},~{N}-dimethyl-benzamide, DI(HYDROXYETHYL)ETHER, ...
Authors:Bayliss, R., Carr, K.H.
Deposit date:2016-10-20
Release date:2016-11-09
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017
5M55
  • Download 5m55
  • View 5m55
Molmil generated image of 5m55
NEK2 BOUND TO ARYLAMINOPURINE 71
Descriptor:Serine/threonine-protein kinase Nek2, 6-[(~{Z})-2-(diethylamino)ethenyl]-~{N}-phenyl-7~{H}-purin-2-amine, SULFATE ION, ...
Authors:Bayliss, R.
Deposit date:2016-10-20
Release date:2016-11-02
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-guided design of purine-based probes for selective Nek2 inhibition.
Oncotarget, 8, 2017