6SK9

Nek2 bound to purine compound 51

Replaces:  6H0O

Summary for 6SK9

• Entry DOI: 10.2210/pdb6sk9/pdb
• Descriptor: Serine/threonine-protein kinase Nek2, 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: ser/thr protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33242.19

Authors

Bayliss, R.,Byrne, M.J.,Mas-Droux, C. (deposition date: 2019-08-15, release date: 2020-06-17)

• Primary citation: Byrne, M.J.,Nasir, N.,Basmadjian, C.,Bhatia, C.,Cunnison, R.F.,Carr, K.H.,Mas-Droux, C.,Yeoh, S.,Cano, C.,Bayliss, R.; Nek7 conformational flexibility and inhibitor binding probed through protein engineering of the R-spine.; Biochem.J., 477:1525-1539, 2020; PubMed: 32242624; DOI: 10.1042/BCJ20200128

Experimental method

X-RAY DIFFRACTION (2 Å)