4Z7G
Crystal structure of human IRE1 cytoplasmic kinase-RNase region - apo
Summary for 4Z7G
Entry DOI | 10.2210/pdb4z7g/pdb |
Descriptor | Serine/threonine-protein kinase/endoribonuclease IRE1, SODIUM ION (3 entities in total) |
Functional Keywords | transferase, kinase, rnase, unfolded protein response |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 95557.62 |
Authors | Bayliss, R.,Joshi, A. (deposition date: 2015-04-07, release date: 2015-05-27, Last modification date: 2024-01-10) |
Primary citation | Joshi, A.,Newbatt, Y.,McAndrew, P.C.,Stubbs, M.,Burke, R.,Richards, M.W.,Bhatia, C.,Caldwell, J.J.,McHardy, T.,Collins, I.,Bayliss, R. Molecular mechanisms of human IRE1 activation through dimerization and ligand binding. Oncotarget, 6:13019-13035, 2015 Cited by PubMed: 25968568DOI: 10.18632/oncotarget.3864 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report