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6D5F
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CRYO-EM RECONSTRUCTION OF MEMBRANE-ENVELOPED FILAMENTOUS VIRUS SFV1 (SULFOLOBUS FILAMENTOUS VIRUS 1)
分子名称:Fimbrial protein, DNA (336-MER)
著者Wang, F., Osinski, T., Liu, Y., Krupovic, M., Prangishvili, D., Egelman, E.H.
登録日2018-04-19
公開日2018-08-29
最終更新日2018-09-12
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile.
Nat Commun, 9, 2018
6GRB
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH POTASSIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRC
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH SODIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.452 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
6GRD
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EUKARYOTIC JUNCTION-RESOLVING ENZYME GEN-1 BINDING WITH CESIUM
分子名称:Nuclease-like protein, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*CP*AP*CP*CP*AP*CP*CP*GP*CP*TP*CP*A)-3'), ...
著者Lilley, D.M.J., Liu, Y., Freeman, D.J.
登録日2018-06-11
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1.
Nucleic Acids Res., 46, 2018
5G06
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CRYO-EM STRUCTURE OF YEAST CYTOPLASMIC EXOSOME
分子名称:EXOSOME COMPLEX COMPONENT RRP45, EXOSOME COMPLEX COMPONENT SKI6, EXOSOME COMPLEX COMPONENT RRP43, ...
著者Liu, J.J., Niu, C.Y., Wu, Y., Tan, D., Wang, Y., Ye, M.D., Liu, Y., Zhao, W.W., Zhou, K., Liu, Q.S., Dai, J.B., Yang, X.R., Dong, M.Q., Huang, N., Wang, H.W.
登録日2016-03-17
公開日2016-06-15
最終更新日2017-08-02
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryoem Structure of Yeast Cytoplasmic Exosome Complex.
Cell Res., 26, 2016
3TI3
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI4
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.602 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI5
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI6
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CRYSTAL STRUCTURE OF 2009 PANDEMIC H1N1 NEURAMINIDASE COMPLEXED WITH OSELTAMIVIR
分子名称:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-23
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TI8
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CRYSTAL STRUCTURE OF INFLUENZA A VIRUS NEURAMINIDASE N5 COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIA
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIB
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH LANINAMIVIR OCTANOATE
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3TIC
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CRYSTAL STRUCTURE OF 1957 PANDEMIC H2N2 NEURAMINIDASE COMPLEXED WITH ZANAMIVIR
分子名称:Neuraminidase, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
著者Vavricka, C.J., Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., He, J., Wang, J., Liu, H., Jiang, H., Gao, G.F.
登録日2011-08-20
公開日2011-11-16
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
Plos Pathog., 7, 2011
3QWY
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CED-2
分子名称:Cell death abnormality protein 2, SULFATE ION, GLYCEROL
著者Kang, Y., Sun, J., Liu, Y., Sun, D., Hu, Y., Liu, Y.F.
登録日2011-02-28
公開日2011-06-08
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Biochem.Biophys.Res.Commun., 410, 2011
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
著者Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
登録日2017-03-23
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
5YFG
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SOLUTION STRUCTURE OF HUMAN MOG1
分子名称:Ran guanine nucleotide release factor
著者Hu, Q., Liu, Y., Bao, X., Liu, H.
登録日2017-09-21
公開日2017-11-01
最終更新日2018-04-11
実験手法SOLUTION NMR
主引用文献Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation
J Mol Cell Biol, 10, 2018
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
分子名称:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
著者Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
登録日2014-08-22
公開日2016-02-24
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
1M63
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CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
分子名称:SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, ...
著者Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.
登録日2002-07-12
公開日2002-09-25
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
3QWX
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CED-2 1-174
分子名称:Cell death abnormality protein 2, SULFATE ION
著者Kang, Y., Sun, J., Liu, Y.
登録日2011-02-28
公開日2011-06-08
最終更新日2011-07-20
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Biochem.Biophys.Res.Commun., 410, 2011
4ZUS
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE REV-QW11
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUT
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-GW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUU
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-CF9
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, CYS-THR-SER-GLU-GLU-MET-ASN-ALA-PHE
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUV
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE ENV-RW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, ARG-VAL-GLU-ASP-VAL-THR-ASN-THR-ALA-GLU-TYR-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUW
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00601) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-GW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
5GON
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STRUCTURES OF A BETA-LACTAM BRIDGED ANALOGUE IN COMPLEX WITH TUBULIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Zhou, L., Liu, Y., Cheng, L., Wang, Y.
登録日2016-07-28
公開日2017-03-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016