4V0R
| DENGUE VIRUS FULL LENGTH NS5 COMPLEXED WITH GTP AND SAH | Descriptor: | FORMIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D. | Deposit date: | 2014-09-18 | Release date: | 2015-01-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015
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1QQC
| CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK | Descriptor: | DNA POLYMERASE II, MAGNESIUM ION, SULFATE ION | Authors: | Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J. | Deposit date: | 1999-06-02 | Release date: | 1999-10-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of an archaebacterial DNA polymerase Structure Fold.Des., 7, 1999
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4V0Q
| Dengue Virus Full Length NS5 Complexed with SAH | Descriptor: | ACETATE ION, GLYCEROL, NS5 POLYMERASE, ... | Authors: | Zhao, Y, Soh, S, Zheng, J, Phoo, W.W, Swaminathan, K, Cornvik, T.C, Lim, S.P, Shi, P.-Y, Lescar, J, Vasudevan, S.G, Luo, D. | Deposit date: | 2014-09-18 | Release date: | 2015-01-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A Crystal Structure of the Dengue Virus Ns5 Protein Reveals a Novel Inter-Domain Interface Essential for Protein Flexibility and Virus Replication. Plos Pathog., 11, 2015
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6G9B
| Crystal structure of Ebolavirus glycoprotein in complex with imipramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, ... | Authors: | Zhao, Y, Ren, J, Fry, E.E, Xiao, J, Townsend, A.R, Stuart, D.I. | Deposit date: | 2018-04-10 | Release date: | 2018-05-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs. J. Med. Chem., 61, 2018
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6GBI
| Wnt signalling | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Ly6/PLAUR domain-containing protein 6, ... | Authors: | Zhao, Y, Jones, E.Y. | Deposit date: | 2018-04-14 | Release date: | 2018-08-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6. FEBS Lett., 592, 2018
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6G9I
| Crystal structure of Ebolavirus glycoprotein in complex with clomipramine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, Envelope glycoprotein,Envelope glycoprotein, ... | Authors: | Zhao, Y, Ren, J, Fry, E.E, Xiao, J, Townsend, A.R, Stuart, D.I. | Deposit date: | 2018-04-10 | Release date: | 2018-05-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs. J. Med. Chem., 61, 2018
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6G95
| Crystal structure of Ebolavirus glycoprotein in complex with thioridazine | Descriptor: | 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Zhao, Y, Ren, J, Fry, E.E, Xiao, J, Townsend, A.R, Stuart, D.I. | Deposit date: | 2018-04-10 | Release date: | 2018-05-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs. J. Med. Chem., 61, 2018
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3JUG
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1FGL
| Cyclophilin A complexed with a fragment of HIV-1 GAG protein | Descriptor: | CYCLOPHILIN A, HIV-1 GAG PROTEIN | Authors: | Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H. | Deposit date: | 1996-11-18 | Release date: | 1997-04-01 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity. Structure, 5, 1997
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6ZYF
| Notum_Ghrelin complex | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | Authors: | Zhao, Y, Jones, E.Y. | Deposit date: | 2020-07-31 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Notum deacylates octanoylated ghrelin. Mol Metab, 49, 2021
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4YVV
| Crystal structure of AKR1C3 complexed with glibenclamide | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhao, Y, Zheng, X, Zhang, H, Hu, X. | Deposit date: | 2015-03-20 | Release date: | 2015-11-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240, 2015
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4YVX
| Crystal structure of AKR1C3 complexed with glimepiride | Descriptor: | 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhao, Y, Zheng, X, Zhang, H, Hu, X. | Deposit date: | 2015-03-20 | Release date: | 2015-11-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240, 2015
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4YVP
| Crystal Structure of AKR1C1 complexed with glibenclamide | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhao, Y, Zheng, X, Zhang, H, Hu, X. | Deposit date: | 2015-03-20 | Release date: | 2015-11-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240, 2015
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7QVZ
| ARUK3001043_Notum | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | Authors: | Zhao, Y, Hillier, J, Willis, N.J, Mahy, W, Fish, P, Jones, E.Y. | Deposit date: | 2022-01-24 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structure Activity Analysis of Notum Fragment Screen Hits with Development To Be Published
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1D5A
| CRYSTAL STRUCTURE OF AN ARCHAEBACTERIAL DNA POLYMERASE D.TOK. DEPOSITION OF SECOND NATIVE STRUCTURE AT 2.4 ANGSTROM | Descriptor: | MAGNESIUM ION, PROTEIN (DNA POLYMERASE), SULFATE ION | Authors: | Zhao, Y, Jeruzalmi, D, Leighton, L, Lasken, R, Kuriyan, J. | Deposit date: | 1999-10-06 | Release date: | 2000-03-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of an archaebacterial DNA polymerase. Structure Fold.Des., 7, 1999
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7R9J
| Methanococcus maripaludis chaperonin, open conformation 4 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9I
| Methanococcus maripaludis chaperonin, open conformation 2 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9K
| Methanococcus maripaludis chaperonin, closed conformation 4 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9H
| Methanococcus maripaludis chaperonin, open conformation 2 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9M
| Methanococcus maripaludis chaperonin, closed conformation 2 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9E
| Methanococcus maripaludis chaperonin, open conformation 1 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7RAK
| Methanococcus maripaludis chaperonin complex in open conformation | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-07-01 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9O
| Methanococcus maripaludis chaperonin, closed conformation 1 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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7R9U
| Methanococcus maripaludis chaperonin, closed conformation 3 | Descriptor: | Chaperonin | Authors: | Zhao, Y, Schmid, M, Frydman, J, Chiu, W. | Deposit date: | 2021-06-29 | Release date: | 2021-08-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin. Nat Commun, 12, 2021
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4ZFC
| Crystal structure of AKR1C3 complexed with glicazide | Descriptor: | Aldo-keto reductase family 1 member C3, N-[(3aR,6aS)-hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl]-4-methylbenzenesulfonamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Zhao, Y, Zhrng, X, Hu, X. | Deposit date: | 2015-04-21 | Release date: | 2015-11-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis Chem.Biol.Interact., 240, 2015
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