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4YVX

Crystal structure of AKR1C3 complexed with glimepiride

Summary for 4YVX
Entry DOI10.2210/pdb4yvx/pdb
Related4YVP 4YVV
DescriptorAldo-keto reductase family 1 member C3, 3-ethyl-4-methyl-N-[2-(4-{[(cis-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-car boxamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsakr1c3 inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P42330
Total number of polymer chains2
Total formula weight76280.50
Authors
Zhao, Y.,Zheng, X.,Zhang, H.,Hu, X. (deposition date: 2015-03-20, release date: 2015-11-25, Last modification date: 2023-11-08)
Primary citationZhao, Y.,Zheng, X.,Zhang, H.,Zhai, J.,Zhang, L.,Li, C.,Zeng, K.,Chen, Y.,Li, Q.,Hu, X.
In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis
Chem.Biol.Interact., 240:310-315, 2015
Cited by
PubMed: 26362498
DOI: 10.1016/j.cbi.2015.09.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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