Author results

6FBV
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SINGLE PARTICLE CRYO EM STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS RNA POLYMERASE IN COMPLEX WITH FIDAXOMICIN
分子名称:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Das, K., Lin, W., Ebright, E.
登録日2017-12-19
公開日2018-02-28
最終更新日2018-10-17
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Mol. Cell, 70, 2018
5WTU
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CRYSTAL STRUCTURE OF DNDE G21/24K MUTANT INVOLVED IN DNA PHOSPHOROTHIOATION
分子名称:DNA sulfur modification protein DndE
著者Yao, P., Liu, Y., Wang, C., Cao, C.
登録日2016-12-14
公開日2018-02-21
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of DndE G21/24K mutant involved in DNA phosphorothioation
To Be Published
5OF9
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CRYSTAL STRUCTURE OF HUMAN MORC2 (RESIDUES 1-603)
分子名称:MORC family CW-type zinc finger protein 2, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Douse, C.H., Shamin, M., Modis, Y.
登録日2017-07-10
公開日2018-02-14
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.807 Å)
主引用文献Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9, 2018
5OFA
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CRYSTAL STRUCTURE OF HUMAN MORC2 (RESIDUES 1-603) WITH SPINAL MUSCULAR ATROPHY MUTATION T424R
分子名称:MORC family CW-type zinc finger protein 2, ZINC ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Douse, C.H., Liu, Y., Modis, Y.
登録日2017-07-10
公開日2018-02-14
最終更新日2018-08-08
実験手法X-RAY DIFFRACTION (2.57 Å)
主引用文献Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9, 2018
5OFB
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CRYSTAL STRUCTURE OF HUMAN MORC2 (RESIDUES 1-603) WITH SPINAL MUSCULAR ATROPHY MUTATION S87L
分子名称:MORC family CW-type zinc finger protein 2, ZINC ION, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Douse, C.H., Liu, Y., Modis, Y.
登録日2017-07-10
公開日2018-02-14
最終更新日2018-08-08
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
Nat Commun, 9, 2018
5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
分子名称:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
著者Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
登録日2017-03-23
公開日2018-02-07
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
5X88
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A CRYSTAL STRUCTURE OF CUTINASES FROM MALBRANCHEA CINNAMOMEA
分子名称:cutinase
著者Jiang, Z., Yang, S.Q., You, X., Huang, P., Ma, J.W.
登録日2017-03-01
公開日2018-01-31
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献High-level expression and characterization of a novel cutinase from Malbranchea cinnamomea suitable for butyl butyrate production.
Biotechnol Biofuels, 10, 2017
5W21
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CRYSTAL STRUCTURE OF A 1:1:1 FGF23-FGFR1C-AKLOTHO TERNARY COMPLEX
分子名称:Klotho, Fibroblast growth factor 23, Fibroblast growth factor receptor 1, ...
著者Mohammadi, M.
登録日2017-06-05
公開日2018-01-24
最終更新日2018-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献alpha-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling.
Nature, 553, 2018
5UHT
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STRUCTURE OF THE THERMOTOGA MARITIMA HK853-BEF3-RR468 COMPLEX AT PH 5.0
分子名称:Sensor histidine kinase, Response regulator, ADENOSINE-5'-DIPHOSPHATE, ...
著者Liu, Y., Rose, J., Jiang, L., Zhou, P.
登録日2017-01-12
公開日2017-12-27
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
Nat Commun, 8, 2017
6AY2
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STRUCTURE OF CATHB WITH COVALENTLY LINKED COMPOUND 28
分子名称:Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
著者Kiefer, J.R., Steinbacher, S.
登録日2017-09-07
公開日2017-12-27
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
6AZR
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CRYSTAL STRUCTURE OF THE T264A HK853CP-BEF3-RR468 COMPLEX
分子名称:Sensor histidine kinase, Chemotaxis regulator-transmits chemoreceptor signals to flagelllar motor components CheY, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Rose, J., Zhou, P.
登録日2017-09-11
公開日2017-12-27
実験手法X-RAY DIFFRACTION (3.628 Å)
主引用文献A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases.
Nat Commun, 8, 2017
6B3E
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CRYSTAL STRUCTURE OF HUMAN CDK12/CYCLINK IN COMPLEX WITH AN INHIBITOR
分子名称:Cyclin-dependent kinase 12, Cyclin-K, MAGNESIUM ION, ...
著者Ferguson, A.D.
登録日2017-09-21
公開日2017-12-27
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Structure-Based Design of Selective Noncovalent CDK12 Inhibitors.
ChemMedChem, 13, 2018
5NS3
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CRYSTAL STRUCTURES OF CY5 CYANINE FLUOROPHORES STACKED ONTO THE END OF DOUBLE-STRANDED RNA
分子名称:50S ribosomal protein L5, double-stranded RNA
著者Liu, Y.J., Lilley, D.M.J.
登録日2017-04-25
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structures of Cyanine Fluorophores Stacked onto the End of Double-Stranded RNA.
Biophys. J., 113, 2017
5NS4
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CRYSTAL STRUCTURES OF CY3 CYANINE FLUOROPHORES STACKED ONTO THE END OF DOUBLE-STRANDED RNA
分子名称:50S ribosomal protein L5, RNA (34-MER), MAGNESIUM ION, ...
著者Liu, Y.J., Lilley, D.M.J.
登録日2017-04-25
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structures of Cyanine Fluorophores Stacked onto the End of Double-Stranded RNA.
Biophys. J., 113, 2017
5WOP
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HIGH RESOLUTION STRUCTURE OF MUTANT CA09-PB2CAP
分子名称:Polymerase PB2, GLYCEROL
著者Constantinides, A.E., Gumpper, R.H., Severin, C., Luo, M.
登録日2017-08-02
公開日2017-12-20
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献High-resolution structure of the Influenza A virus PB2cap binding domain illuminates the changes induced by ligand binding.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5XXE
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CRYSTAL STRUCTURE OF POZ1 AND TPZ1
分子名称:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ...
著者Xue, J., Chen, H., Wu, J., Lei, M.
登録日2017-07-03
公開日2017-12-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
5XXF
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CRYSTAL STRUCTURE OF POZ1, TPZ1 AND RAP1
分子名称:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ...
著者Xue, J., Chen, H., Wu, J., Lei, M.
登録日2017-07-03
公開日2017-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
6BPH
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CRYSTAL STRUCTURE OF THE CHROMODOMAIN OF RBBP1
分子名称:AT-rich interactive domain-containing protein 4A, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-11-23
公開日2017-12-20
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of chromo barrel domain of RBBP1.
Biochem. Biophys. Res. Commun., 496, 2018
5XF7
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CRYSTAL STRUCTURE OF HUMAN PROTEIN DISULFIDE ISOMERASE-LIKE PROTEIN OF THE TESTIS
分子名称:Protein disulfide-isomerase-like protein of the testis
著者Li, H., Li, J., Liu, Y., Liang, H.
登録日2017-04-08
公開日2017-12-13
最終更新日2018-02-07
実験手法X-RAY DIFFRACTION (2.381 Å)
主引用文献Crystal and solution structures of human protein-disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity
J. Biol. Chem., 293, 2018
5XMF
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CRYSTAL STRUCTURE OF FELINE MHC CLASS I FOR 2,1 ANGSTROM
分子名称:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
著者Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
登録日2017-05-15
公開日2017-12-13
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
5XMM
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FLA-E*01801-167W/S
分子名称:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
著者Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
登録日2017-05-15
公開日2017-12-13
最終更新日2019-01-16
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
5X6B
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CRYSTAL STRUCTURE OF SEPCYSE-SEPCYSS IN COMPLEX WITH TRNACYS FROM METHANOCALDOCOCCUS JANNASCHII
分子名称:O-phospho-L-seryl-tRNA:Cys-tRNA synthase, Uncharacterized protein MJ1481, tRNACys
著者Chen, M., Kato, K., Yao, M.
登録日2017-02-21
公開日2017-12-06
実験手法X-RAY DIFFRACTION (2.596 Å)
主引用文献Structural basis for tRNA-dependent cysteine biosynthesis
Nat Commun, 8, 2017
5X6C
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CRYSTAL STRUCTURE OF SEPRS-SEPCYSE FROM METHANOCALDOCOCCUS JANNASCHII
分子名称:O-phosphoserine--tRNA(Cys) ligase, Uncharacterized protein MJ1481, ADENOSINE-5'-TRIPHOSPHATE, ...
著者Chen, M., Kato, K., Yao, M.
登録日2017-02-21
公開日2017-12-06
実験手法X-RAY DIFFRACTION (3.101 Å)
主引用文献Structural basis for tRNA-dependent cysteine biosynthesis
Nat Commun, 8, 2017
6BHD
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION, ...
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
6BHE
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CRYSTAL STRUCTURE OF SETDB1 WITH A MODIFIED H3 PEPTIDE
分子名称:Histone-lysine N-methyltransferase SETDB1, Histone H3.1, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2017-10-30
公開日2017-12-06
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017