Author results

4KQ4
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CRYSTAL STRUCTURE OF ANTI-IL-17A ANTIBODY CNTO7357
Descriptor:CNTO7357 light chain, CNTO7357 heavy chain, NICKEL (II) ION
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2013-05-14
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Antibody modeling assessment II. Structures and models.
Proteins, 82, 2014
4KUZ
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CRYSTAL STRUCTURE OF ANTI-EMMPRIN ANTIBODY 4A5 FAB IN TRIGONAL FORM
Descriptor:antibody 4A5 light chain, antibody 4A5 heavy chain, SULFATE ION
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-05-22
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural evidence for a constrained conformation of short CDR-L3 in antibodies.
Proteins, 82, 2014
4LPT
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CRYSTAL STRUCTURE OF MONOMERIC TENCON VARIANT P54CR4-31
Descriptor:TENCON variant P54CR4-31
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.544 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4LPU
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CRYSTAL STRUCTURE OF TENCON VARIANT P40AR2-32R2
Descriptor:TENCON variant P40AR2-32R2
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4LPV
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CRYSTAL STRUCTURE OF TENCON VARIANT P41BR3-42
Descriptor:TENCON variant P41BR3-42, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Teplyakov, A., Obmolova, G., Luo, J., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4LPW
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CRYSTAL STRUCTURE OF TENCON VARIANT A6
Descriptor:TENCON variant A6
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4LPX
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CRYSTAL STRUCTURE OF TENCON VARIANT D4
Descriptor:TENCON variant D4
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4LPY
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CRYSTAL STRUCTURE OF TENCON VARIANT G10
Descriptor:TENCON variant G10, SODIUM ION
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-07-16
Release date:2014-01-29
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:C-terminal beta-strand swapping in a consensus-derived fibronectin Type III scaffold.
Proteins, 82, 2014
4M6A
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N-TERMINAL BETA-STRAND SWAPPING IN A CONSENSUS DERIVED ALTERNATIVE SCAFFOLD DRIVEN BY STABILIZING HYDROPHOBIC INTERACTIONS
Descriptor:Tencon
Authors:Luo, J., Teplyakov, A., Obmolova, G., Malia, T.J., Chan, W., Jocobs, S.A., O'neil, K.T., Gilliland, G.L.
Deposit date:2013-08-09
Release date:2014-02-26
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:N-terminal beta-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions.
Proteins, 82, 2014
4M6M
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CRYSTAL STRUCTURE OF ANTI-IL-23 ANTIBODY CNTO1959 AT PH 9.5
Descriptor:CNTO1959 light chain, CNTO1959 heavy chain, GLYCEROL, ...
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-08-09
Release date:2014-03-26
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antibody modeling assessment II. Structures and models.
Proteins, 82, 2014
4M6N
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CRYSTAL STRUCTURE OF ANTI-IL-23 ANTIBODY CNTO1959 AT PH 6.5
Descriptor:CNTO1959 light chain, CNTO1959 heavy chain, FORMIC ACID
Authors:Teplyakov, A., Obmolova, G., Gilliland, G.L.
Deposit date:2013-08-09
Release date:2014-08-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:crystal structure of anti-IL-23 antibody CNTO1959 at pH 6.5
To be Published
4M6O
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CRYSTAL STRUCTURE OF ANTI-NGF ANTIBODY CNTO7309
Descriptor:CNTO7309 light chain, CNTO7309 heavy chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2013-08-09
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Antibody modeling assessment II. Structures and models.
Proteins, 82, 2014
4M7K
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CRYSTAL STRUCTURE OF ANTI-TISSUE FACTOR ANTIBODY 10H10
Descriptor:10H10 light chain, 10H10 heavy chain, CALCIUM ION, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2013-08-12
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antibody modeling assessment II. Structures and models.
Proteins, 82, 2014
4M7L
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN TISSUE FACTOR EXTRACELLULAR DOMAIN AND ANTIBODY 10H10 FAB FRAGMENT
Descriptor:Tissue factor, 10H10 light chain, 10H10 heavy chain
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2013-08-12
Release date:2014-08-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structure of the complex between human tissue factor extracellular domain and antibody 10H10 FAB fragment
To be Published
4MA3
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CRYSTAL STRUCTURE OF ANTI-HINGE RABBIT ANTIBODY C2095
Descriptor:C2095 light chain, C2095 heavy chain, ACETATE ION, ...
Authors:Malia, T., Teplyakov, A., Gilliland, G.L.
Deposit date:2013-08-15
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.
Proteins, 82, 2014
4MAU
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CRYSTAL STRUCTURE OF ANTI-ST2L ANTIBODY C2244
Descriptor:C2244 light chain, C2244 heavy chain, GLYCEROL, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2013-08-16
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antibody modeling assessment II. Structures and models.
Proteins, 82, 2014
4O4Y
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CRYSTAL STRUCTURE OF THE ANTI-HINGE RABBIT ANTIBODY 2095-2 IN COMPLEX WITH IDES HINGE PEPTIDE
Descriptor:2095-2 light chain, 2095-2 heavy chain, IDES hinge peptide, ...
Authors:Malia, T.J., Teplyakov, A., Luo, J., Gilliland, G.L.
Deposit date:2013-12-19
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.
Proteins, 82, 2014
4O51
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CRYSTAL STRUCTURE OF THE QAA VARIANT OF ANTI-HINGE RABBIT ANTIBODY 2095-2 IN COMPLEX WITH IDES HINGE PEPTIDE
Descriptor:QAA-2095-2 light chain, QAA-2095-2 heavy chain, IDES hinge peptide
Authors:Malia, T.J., Luo, J., Teplyakov, A., Gilliland, G.L.
Deposit date:2013-12-19
Release date:2014-03-26
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.
Proteins, 82, 2014
4QHU
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CRYSTAL STRUCTURE OF IL-17A/FAB6785 COMPLEX
Descriptor:Fab6785 light chain, Fab6785 heavy chain, Interleukin-17A, ...
Authors:Luo, J., Gilliland, G.L., Malia, T., Obmolova, G., Teplyakov, A.
Deposit date:2014-05-29
Release date:2015-08-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:IL-17A Asymmetry in a Complex with a Neutralizing Antibody Fab6785 Reveals a Potential Mechanism of Receptor Differentiation
To be Published
5EUG
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CRYSTALLOGRAPHIC AND ENZYMATIC STUDIES OF AN ACTIVE SITE VARIANT H187Q OF ESCHERICHIA COLI URACIL DNA GLYCOSYLASE: CRYSTAL STRUCTURES OF MUTANT H187Q AND ITS URACIL COMPLEX
Descriptor:PROTEIN (GLYCOSYLASE), URACIL
Authors:Xiao, G., Tordova, M., Drohat, A.C., Jagadeesh, J., Stivers, J.T., Gilliland, G.L.
Deposit date:1998-12-27
Release date:1999-07-23
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.
Proteins, 35, 1999
5TL5
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COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, CD27 antigen, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-10
Release date:2017-06-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of CD27 in complex with a neutralizing noncompeting antibody.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5TLJ
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COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, M2191 LIGHT CHAIN, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5TLK
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COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191
Descriptor:M2177 LIGHT CHAIN, M2177 HEAVY CHAIN, H2191 LIGHT CHAIN, ...
Authors:Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5UBX
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CRYSTAL STRUCTURE OF A MUTANT MIGG2B FC HETERODIMER IN COMPLEX WITH PROTEIN A PEPTIDE ANALOG Z34C
Descriptor:Ig gamma-2B chain C region, Peptide analog of B-domain from Protein A - Z34C, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Armstrong, A.A., Zwolak, A., Gilliland, G.L.
Deposit date:2016-12-21
Release date:2017-09-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.
MAbs, 9, 2017
5VME
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CRYSTAL STRUCTURE OF HUMAN IGG1 FC K248E, T437R MUTANT
Descriptor:human IgG1 Fc K248E,T437R mutant, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Armstrong, A.A., Gilliland, G.L.
Deposit date:2017-04-27
Release date:2017-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.
MAbs, 9, 2017