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3KTU
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BU of 3ktu by Molmil
Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
Descriptor: CALCIUM ION, DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3'), ...
Authors:Verdine, G.L, Lee, S.M.
Deposit date:2009-11-26
Release date:2010-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural investigation of hOGG1 bound to a fluorinated oxoG analog
to be published
3IH7
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BU of 3ih7 by Molmil
Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA
Descriptor: 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', 5'-D(AP*TP*CP*TP*GP*GP*AP*CP*CP*TP*GP*CP*A)-3', N-glycosylase/DNA lyase
Authors:Verdine, G.L, Crenshaw, C.M, Oo, K.S, Kutchukian, P.S.
Deposit date:2009-07-29
Release date:2010-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1
To be Published
3UBT
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BU of 3ubt by Molmil
Crystal Structure of C71S Mutant of DNA Cytosine-5 Methyltransferase M.HaeIII Bound to DNA
Descriptor: 5'-D(*TP*GP*GP*CP*CP*A)-3', ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ...
Authors:Verdine, G.L, Didovyk, A.
Deposit date:2011-10-24
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.502 Å)
Cite:Structural origins of DNA target selection and nucleobase extrusion by a DNA Cytosine methyltransferase.
J.Biol.Chem., 287, 2012
5WHE
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BU of 5whe by Molmil
KRas G12V/D38P, bound to GppNHp and miniprotein 225-11
Descriptor: CALCIUM ION, GTPase KRas, MAGNESIUM ION, ...
Authors:Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L.
Deposit date:2017-07-16
Release date:2018-01-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
5WPL
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BU of 5wpl by Molmil
KRas G12V, bound to GppNHp and miniprotein 225-11
Descriptor: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ...
Authors:Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L.
Deposit date:2017-08-05
Release date:2018-01-03
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
1ZXN
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BU of 1zxn by Molmil
Human DNA topoisomerase IIa ATPase/ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA topoisomerase II, alpha isozyme, ...
Authors:Wei, H, Ruthenburg, A.J, Bechis, S.K, Verdine, G.L.
Deposit date:2005-06-08
Release date:2005-08-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase.
J.Biol.Chem., 280, 2005
3SAS
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BU of 3sas by Molmil
MUTM Slanted complex 4 with R112A mutation
Descriptor: 5'-D(*A*GP*GP*TP*AP*GP*AP*CP*TP*CP*GP*GP*AP*CP*GP*C)-3', 5'-D(*T*GP*CP*GP*TP*CP*CP*GP*AP*GP*(TX2) P*CP*TP*AP*CP*C)-3', DNA GLYCOSYLASE, ...
Authors:Qi, Y, Verdine, G.L.
Deposit date:2011-06-03
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Strandwise translocation of a DNA glycosylase on undamaged DNA.
Proc.Natl.Acad.Sci.USA, 109, 2012
5KN9
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BU of 5kn9 by Molmil
MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair
Descriptor: Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ...
Authors:Wang, L, Chakravarthy, S, Verdine, G.L.
Deposit date:2016-06-27
Release date:2017-02-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.
J. Biol. Chem., 292, 2017
5KN8
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BU of 5kn8 by Molmil
MutY N-terminal domain in complex with undamaged DNA
Descriptor: Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ...
Authors:Wang, L, Chakravarthy, S, Verdine, G.L.
Deposit date:2016-06-27
Release date:2017-02-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase.
J. Biol. Chem., 292, 2017
1ADN
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BU of 1adn by Molmil
SOLUTION STRUCTURE OF THE DNA METHYLPHOSPHOTRIESTER REPAIR DOMAIN OF ESCHERICHIA COLI ADA
Descriptor: N-ADA 10, ZINC ION
Authors:Myers, L.C, Verdine, G.L, Wagner, G.
Deposit date:1993-09-30
Release date:1994-01-31
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the DNA methyl phosphotriester repair domain of Escherichia coli Ada.
Biochemistry, 32, 1993
4YPR
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BU of 4ypr by Molmil
Crystal Structure of D144N MutY bound to its anti-substrate
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-13
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
4YPH
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BU of 4yph by Molmil
Crystal Structure of MutY bound to its anti-substrate with the disulfide cross-linker reduced
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(TP*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-12
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
4YOQ
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BU of 4yoq by Molmil
Crystal Structure of MutY bound to its anti-substrate
Descriptor: A/G-specific adenine glycosylase, DNA (5'-D(*AP*AP*GP*AP*CP*(8OG)P*TP*GP*GP*AP*C)-3'), DNA (5'-D(*T*GP*TP*CP*CP*AP*CP*GP*TP*CP*T)-3'), ...
Authors:Wang, L, Lee, S, Verdine, G.L.
Deposit date:2015-03-11
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase.
J.Biol.Chem., 290, 2015
6O8E
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BU of 6o8e by Molmil
Crystal structure of UvrB bound to duplex DNA with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*GP*CP*CP*GP*TP*AP*TP*GP*CP*CP*AP*AP*TP*CP*TP*AP*GP*AP*GP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8G
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BU of 6o8g by Molmil
Crystal structure of UvrB bound to fully duplex DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*CP*GP*AP*TP*GP*GP*AP*GP*A)-3'), ...
Authors:Lee, S.-J, Sung, R.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8F
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BU of 6o8f by Molmil
Crystal structure of UvrB bound to duplex DNA
Descriptor: ACETATE ION, CHLORIDE ION, DNA (5'-D(*GP*CP*CP*GP*TP*AP*TP*GP*CP*CP*AP*AP*TP*CP*TP*AP*GP*AP*GP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6O8H
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BU of 6o8h by Molmil
Crystal structure of UvrB mutant bound to duplex DNA
Descriptor: CHLORIDE ION, DNA (5'-D(P*AP*GP*CP*GP*CP*GP*AP*TP*GP*GP*AP*GP*A)-3'), DNA (5'-D(P*CP*CP*AP*TP*CP*GP*CP*GP*CP*TP*AP*CP*C)-3'), ...
Authors:Lee, S.-J, Verdine, G.L.
Deposit date:2019-03-10
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Mechanism of DNA Lesion Homing and Recognition by the Uvr Nucleotide Excision Repair System.
Res, 2019, 2019
6OQA
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BU of 6oqa by Molmil
Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product
Descriptor: (3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ...
Authors:Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L.
Deposit date:2019-04-26
Release date:2020-04-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
Proc.Natl.Acad.Sci.USA, 117, 2020
3OH9
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BU of 3oh9 by Molmil
AlkA Undamaged DNA Complex: Interrogation of a T:A base pair
Descriptor: 5'-D(*AP*CP*AP*(BRU)P*GP*AP*AP*(BRU)P*GP*CP*C)-3', 5'-D(*GP*GP*CP*AP*TP*TP*CP*AP*TP*GP*T)-3', DNA-3-methyladenine glycosylase 2
Authors:Bowman, B.R, Lee, S, Wang, S, Verdine, G.L.
Deposit date:2010-08-17
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of Escherichia coli AlkA in Complex with Undamaged DNA.
J.Biol.Chem., 285, 2010
3OGD
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BU of 3ogd by Molmil
AlkA Undamaged DNA Complex: Interrogation of a G*:C base pair
Descriptor: 5'-D(*CP*AP*(BRU)P*GP*AP*CP*(BRU)P*GP*C)-3', 5'-D(*GP*CP*AP*GP*TP*CP*AP*TP*G)-3', DNA-3-methyladenine glycosylase 2
Authors:Bowman, B.R, Lee, S, Wang, S, Verdine, G.L.
Deposit date:2010-08-16
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Escherichia coli AlkA in Complex with Undamaged DNA.
J.Biol.Chem., 285, 2010
3OH6
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BU of 3oh6 by Molmil
AlkA Undamaged DNA Complex: Interrogation of a C:G base pair
Descriptor: 5'-D(*GP*AP*CP*AP*(BRU)P*GP*AP*AP*(BRU)P*GP*CP*C)-3', 5'-D(*GP*CP*AP*TP*TP*CP*AP*TP*GP*TP*C)-3', DNA-3-methyladenine glycosylase 2
Authors:Bowman, B.R, Lee, S, Wang, S, Verdine, G.L.
Deposit date:2010-08-17
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Structure of Escherichia coli AlkA in Complex with Undamaged DNA.
J.Biol.Chem., 285, 2010
1DCT
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BU of 1dct by Molmil
DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Descriptor: CALCIUM ION, DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3'), ...
Authors:Reinisch, K.M, Chen, L, Verdine, G.L, Lipscomb, W.N.
Deposit date:1995-05-17
Release date:1995-09-15
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.
Cell(Cambridge,Mass.), 82, 1995
1FN7
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BU of 1fn7 by Molmil
COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN
Descriptor: 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ...
Authors:Norman, D.P.G, Bruner, S.D, Verdine, G.L.
Deposit date:2000-08-21
Release date:2001-04-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein.
J.Am.Chem.Soc., 123, 2001
1A3Q
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BU of 1a3q by Molmil
HUMAN NF-KAPPA-B P52 BOUND TO DNA
Descriptor: DNA (5'-D(*GP*GP*GP*GP*AP*AP*TP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*AP*TP*TP*CP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B P52)
Authors:Cramer, P, Larson, C.J, Verdine, G.L, Muller, C.W.
Deposit date:1998-01-23
Release date:1998-06-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution.
EMBO J., 16, 1997
1A66
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BU of 1a66 by Molmil
SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES
Descriptor: CORE NFATC1, DNA (5'-D(*CP*AP*AP*TP*TP*TP*TP*CP*CP*TP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*GP*GP*AP*AP*AP*AP*TP*TP*G)-3')
Authors:Zhou, P, Sun, L.J, Doetsch, V, Wagner, G, Verdine, G.L.
Deposit date:1998-03-06
Release date:1998-06-17
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the core NFATC1/DNA complex.
Cell(Cambridge,Mass.), 92, 1998

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