Author results

3IR3
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CRYSTAL STRUCTURE OF HUMAN 3-HYDROXYACYL-THIOESTER DEHYDRATASE 2 (HTD2)
Descriptor:3-hydroxyacyl-thioester dehydratase 2, MALONATE ION
Authors:Ugochukwu, E., Cocking, R., Burgess-Brown, N., Pilka, E., Muniz, J., Krojer, T., Chaikuad, A., Gileadi, O., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-08-21
Release date:2009-09-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystal structure of human 3-hydroxyacyl-thioester dehydratase 2 (HTD2)
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3ZI1
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CRYSTAL STRUCTURE OF HUMAN GLYOXALASE DOMAIN-CONTAINING PROTEIN 4 (GLOD4)
Descriptor:GLYOXALASE DOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL
Authors:Oberholzer, A., Kiyani, W., Shrestha, L., Vollmar, M., Krojer, T., Froese, D.S., Williams, E., von Delft, F., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2012-12-30
Release date:2013-01-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Glyoxalase Domain- Containing Protein 4 (Glod4)
To be Published
3ZW5
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CRYSTAL STRUCTURE OF THE HUMAN GLYOXALASE DOMAIN-CONTAINING PROTEIN 5
Descriptor:GLYOXALASE DOMAIN-CONTAINING PROTEIN 5, SULFATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Muniz, J.R.C., Kiyani, W., Froese, S., Vollmar, M., von Delft, F., Burgess-Brown, N., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Yue, W.W.
Deposit date:2011-07-28
Release date:2011-08-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human Glyoxalase Domain-Containing Protein 5
To be Published
3ZWF
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CRYSTAL STRUCTURE OF HUMAN TRNASE Z, SHORT FORM (ELAC1).
Descriptor:ZINC PHOSPHODIESTERASE ELAC PROTEIN 1, 1,2-ETHANEDIOL, ZINC ION, ...
Authors:Allerston, C.K., Krojer, T., Berridge, G., Burgess-Brown, N., Chaikuad, A., Chalk, R., Elkins, J.M., Gileadi, C., Latwiel, S.V.A., Savitsky, P., Vollmar, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2011-07-29
Release date:2011-08-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Human Trnase Z, Short Form (Elac1).
To be Published
4AGU
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CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
Descriptor:CYCLIN-DEPENDENT KINASE-LIKE 1, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Authors:Canning, P., Sharpe, T.D., Allerston, C., Savitsky, P., Pike, A.C.W., Muniz, J.R.C., Chaikuad, A., Kuo, K., Burgess-Brown, N., Ayinampudi, V., Zhang, Y., Thangaratnarajah, C., Ugochukwu, E., Vollmar, M., Krojer, T., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., von Delft, F., Knapp, S., Bullock, A.
Deposit date:2012-01-31
Release date:2012-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Human Cdkl1 Kinase Domain
To be Published
4AP8
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CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT (MOCS2B)
Descriptor:MOLYBDOPTERIN SYNTHASE CATALYTIC SUBUNIT, GLYCEROL, 1,2-ETHANEDIOL
Authors:Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Allerston, C., Froese, D.S., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
Deposit date:2012-03-30
Release date:2012-08-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Crystal Structure of Human Molybdopterin Synthase Catalytic Subunit (Mocs2B)
To be Published
4AYW
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STRUCTURE OF THE HUMAN MITOCHONDRIAL ABC TRANSPORTER, ABCB10 (PLATE FORM)
Descriptor:ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Pike, A.C.W., Shintre, C.A., Li, Q., Kim, J., von Delft, F., Barr, A.J., Das, S., Chaikuad, A., Xia, X., Quigley, A., Dong, Y., Dong, L., Krojer, T., Vollmar, M., Muniz, J.R.C., Bray, J.E., Berridge, G., Chalk, R., Gileadi, O., Burgess-Brown, N., Shrestha, L., Goubin, S., Yang, J., Mahajan, P., Mukhopadhyay, S., Bullock, A.N., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Carpenter, E.P.
Deposit date:2012-06-22
Release date:2012-07-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structures of Abcb10, a Human ATP-Binding Cassette Transporter in Apo- and Nucleotide-Bound States
Proc.Natl.Acad.Sci.USA, 110, 2013
4B4C
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CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN CHD1.
Descriptor:CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, SULFATE ION, 1,2-ETHANEDIOL, ...
Authors:Allerston, C.K., Cooper, C.D.O., Shrestha, L., Vollmar, M., Burgess-Brown, N., Yue, W.W., Carpenter, E.P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O.
Deposit date:2012-07-30
Release date:2012-08-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal Structure of the DNA-Binding Domain of Human Chd1.
To be Published
4BGJ
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CRYSTAL STRUCTURE OF THE PHOX-HOMOLOGY DOMAIN OF HUMAN SORTING NEXIN 14
Descriptor:SORTING NEXIN-14
Authors:Vollmar, M., Kiyani, W., Shrestha, L., Goubin, S., Krojer, T., Pike, A.C.W., Carpenter, E., Quigley, A., McKenzie, A., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Yue, W.W.
Deposit date:2013-03-27
Release date:2013-05-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of the Phox-Homology Domain of Human Sorting Nexin 14
To be Published
4BQM
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CRYSTAL STRUCTURE OF HUMAN LIVER-TYPE GLUTAMINASE, CATALYTIC DOMAIN
Descriptor:GLUTAMINASE LIVER ISOFORM, MITOCHONDRIAL, 1,2-ETHANEDIOL, ...
Authors:Ferreira, I.M., Vollmar, M., Krojer, T., Strain-Damerell, C., Froese, S., Coutandin, D., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Dias, S.M.G., Ambrosio, A.L.B., Yue, W.W.
Deposit date:2013-05-31
Release date:2013-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal Structure of Human Liver-Type Glutaminase, Catalytic Domain
To be Published
4C45
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CRYSTAL STRUCTURE OF HUMAN PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2 (PCBD2)
Descriptor:PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE 2, 1,2-ETHANEDIOL
Authors:Kopec, J., Kiyani, W., Vollmar, M., Shrestha, L., Canning, P., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
Deposit date:2013-08-30
Release date:2013-09-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure of Human Pterin-4-Alpha- Carbinolamine Dehydratase 2 (Pcbd2)
To be Published
4CCZ
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CRYSTAL STRUCTURE OF HUMAN 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE, THE HOMOCYSTEINE AND FOLATE BINDING DOMAINS
Descriptor:METHIONINE SYNTHASE, (6S)-5,6,7,8-TETRAHYDROFOLATE
Authors:Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Burgess-Brown, N., von Delft, F., Oppermann, U., Edwards, A., Arrowsmith, C., Bountra, C., Yue, W.W.
Deposit date:2013-10-29
Release date:2013-11-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human 5-Methyltetrahydrofolate-Homocysteine Methyltransferase, the Homocysteine and Folate Binding Domains
To be Published
4D6Q
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CRYSTAL STRUCTURE OF HUMAN JMJD2D IN COMPLEX WITH 2,4-PDCA
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, NICKEL (II) ION, ...
Authors:Krojer, T., Vollmar, M., Bradley, A., Crawley, L., Szykowska, A., Burgess-Brown, N., Gileadi, C., Johansson, C., Oppermann, U., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2014-11-14
Release date:2014-12-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.292 Å)
Cite:Crystal Structure of Human Jmjd2D in Complex with 2,4-Pdca
To be Published
4D6R
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CRYSTAL STRUCTURE OF HUMAN JMJD2D IN COMPLEX WITH N-OXALYLGLYCINE AND BOUND O-TOLUENESULFONAMIDE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, NICKEL (II) ION, ...
Authors:Krojer, T., Vollmar, M., Bradley, A., Crawley, L., Szykowska, A., Burgess-Brown, N., Gileadi, C., Johansson, C., Oppermann, U., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2014-11-14
Release date:2014-12-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.398 Å)
Cite:Crystal Structure of Human Jmjd2D in Complex with N-Oxalylglycine and Bound O-Toluenesulfonamide
To be Published
4D6S
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CRYSTAL STRUCTURE OF HUMAN JMJD2D IN COMPLEX WITH N-OXALYLGLYCINE AND BOUND 5,6-DIMETHYLBENZIMIDAZOLE
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4D, ZINC ION, NICKEL (II) ION, ...
Authors:Krojer, T., Vollmar, M., Bradley, A., Crawley, L., Szykowska, A., Burgess-Brown, N., Gileadi, C., Johansson, C., Oppermann, U., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2014-11-14
Release date:2014-12-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of Human Jmjd2D in Complex with N-Oxalylglycine and Bound 5,6- Dimethylbenzimidazole
To be Published
4HAS
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CRYSTAL STRUCTURE OF PX DOMAIN OF HUMAN SORTING NEXIN SNX27
Descriptor:Sorting nexin-27, CITRIC ACID, 1,2-ETHANEDIOL
Authors:Froese, D.S., Krojer, T., Strain-Damerell, C., Allerston, C., Kiyani, W., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Bountra, C., Edwards, A., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2012-09-27
Release date:2013-04-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structure of PX domain of human sorting nexin SNX27
To be Published
4MHV
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CRYSTAL STRUCTURE OF THE PNT DOMAIN OF HUMAN ETS2
Descriptor:Protein C-ets-2, CALCIUM ION, GLYCEROL, ...
Authors:Newman, J.A., Cooper, C.D.O., Krojer, T., Shrestha, L., Burgess-brown, N., Arrowsmith, C.H., Bountra, C., Edwards, A., Gileadi, O.
Deposit date:2013-08-30
Release date:2013-09-25
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the PNT domain of human ETS2
To be Published
4PTB
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CRYSTAL STRUCTURE OF HUMAN SP100 PHD-BROMODOMAIN IN THE FREE STATE
Descriptor:Nuclear autoantigen Sp-100, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Tallant, C., Nunez-Alonso, G., Savitsky, P., Newman, J., Krojer, T., Szykowska, A., Burgess-Brown, N., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2014-03-10
Release date:2014-04-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human SP100 PHD-Bromodomain in the free state
To be Published
4UEG
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CRYSTAL STRUCTURE OF HUMAN GLYCOGENIN-2 CATALYTIC DOMAIN
Descriptor:GLYCOGENIN-2, MAGNESIUM ION
Authors:Fairhead, M., Strain-Damerell, C., Krojer, T., Froese, D.S., Kopec, J., Nowak, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-12-17
Release date:2014-12-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal Structure of Human Glycogenin-2 Catalytic Domain
To be Published
4URJ
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CRYSTAL STRUCTURE OF HUMAN BJ-TSA-9
Descriptor:PROTEIN FAM83A, 1,2-ETHANEDIOL
Authors:Pinkas, D.M., Sanvitale, C., Wang, D., Krojer, T., Kopec, J., Chaikuad, A., Dixon Clarke, S., Berridge, G., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-06-30
Release date:2014-10-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal Structure of Human Bj-Tsa-9
To be Published
4UUC
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CRYSTAL STRUCTURE OF HUMAN ASB11 ANKYRIN REPEAT DOMAIN
Descriptor:ANKYRIN REPEAT AND SOCS BOX PROTEIN 11
Authors:Pinkas, D.M., Sanvitale, C., Kragh Nielsen, T., Guo, K., Sorrell, F., Berridge, G., Ayinampudi, V., Wang, D., Newman, J.A., Tallant, C., Chaikuad, A., Canning, P., Kopec, J., Krojer, T., Vollmar, M., Allerston, C.K., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Bullock, A.
Deposit date:2014-07-25
Release date:2014-08-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Human Asb11 Ankyrin Repeat Domain
To be Published
4UY4
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1.86 A STRUCTURE OF HUMAN SPINDLIN-4 PROTEIN IN COMPLEX WITH HISTONE H3K4ME3 PEPTIDE
Descriptor:SPINDLIN-4, HISTONE H3K4ME3, GLYCEROL
Authors:Talon, R., Gileadi, C., Johansson, C., Burgess-Brown, N., Shrestha, L., von Delft, F., Krojer, T., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Oppermann, U.
Deposit date:2014-08-28
Release date:2014-09-24
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.862 Å)
Cite:1.86 A Structure of Human Spindlin-4 Protein in Complex with Histone H3K4Me3 Peptide
To be Published
4UYB
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CRYSTAL STRUCTURE OF SEC14-LIKE PROTEIN 3
Descriptor:SEC14-LIKE PROTEIN 3, 1,2-ETHANEDIOL, UNKNOWN LIGAND
Authors:Kopec, J., Goubin, S., Krojer, T., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-08-29
Release date:2014-09-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Sec14-Like Protein 3
To be Published
4V06
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CRYSTAL STRUCTURE OF HUMAN TRYPTOPHAN HYDROXYLASE 2 (TPH2), CATALYTIC DOMAIN
Descriptor:TRYPTOPHAN 5-HYDROXYLASE 2, IMIDAZOLE, FE (III) ION
Authors:Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-09-11
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published