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4ME2
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CRYSTAL STRUCTURE OF THA8 PROTEIN FROM BRACHYPODIUM DISTACHYON
Descriptor:Uncharacterized protein
Authors:Ke, J., Chen, R.Z., Ban, T., Brunzelle, J.S., Gu, X., Melcher, K., Xu, H.E.
Deposit date:2013-08-24
Release date:2013-10-30
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for RNA recognition by a dimeric PPR-protein complex.
Nat.Struct.Mol.Biol., 20, 2013
4MY2
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CRYSTAL STRUCTURE OF NORRIN IN FUSION WITH MALTOSE BINDING PROTEIN
Descriptor:Maltose-binding periplasmic protein, Norrin fusion protein, MALTOSE
Authors:Ke, J., Jurecky, C., Chen, C., Gu, X., Parker, N., Williams, B.O., Melcher, K., Xu, H.E.
Deposit date:2013-09-27
Release date:2013-11-13
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
Genes Dev., 27, 2013
4N2Q
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CRYSTAL STRUCTURE OF THA8 IN COMPLEX WITH ZM4 RNA
Descriptor:THA8 RNA binding protein, RNA (5'-R(*AP*AP*GP*AP*AP*GP*AP*AP*AP*UP*UP*GP*G)-3')
Authors:Ke, J., Chen, R.Z., Ban, T., Zhou, X.E., Gu, X., Brunzelle, J.S., Zhu, J.K., Melcher, K., Xu, H.E.
Deposit date:2013-10-06
Release date:2013-10-30
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for RNA recognition by a dimeric PPR-protein complex.
Nat.Struct.Mol.Biol., 20, 2013
4N2S
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CRYSTAL STRUCTURE OF THA8 IN COMPLEX WITH ZM1A-6 RNA
Descriptor:THA8 RNA binding protein, Zm1a-6 RNA
Authors:Ke, J., Chen, R.Z., Ban, T., Zhou, X.E., Gu, X., Brunzelle, J.S., Zhu, J.K., Melcher, K., Xu, H.E.
Deposit date:2013-10-06
Release date:2013-10-30
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for RNA recognition by a dimeric PPR-protein complex.
Nat.Struct.Mol.Biol., 20, 2013
4NUF
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CRYSTAL STRUCTURE OF SHP/EID1
Descriptor:Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, EID1 peptide, ...
Authors:Zhi, X., Zhou, X.E., He, Y., Zechner, C., Suino-Powell, K.M., Kliewer, S.A., Melcher, K., Mangelsdorf, D.J., Xu, H.E.
Deposit date:2013-12-03
Release date:2014-01-29
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into gene repression by the orphan nuclear receptor SHP.
Proc.Natl.Acad.Sci.USA, 111, 2014
4RED
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CRYSTAL STRUCTURE OF HUMAN AMPK ALPHA1 KD-AID WITH K43A MUTATION
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-22
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4RER
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX BOUND TO AMP AND CYCLODEXTRIN
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-23
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (4.047 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4REW
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CRYSTAL STRUCTURE OF THE NON-PHOSPHORYLATED HUMAN ALPHA1 BETA2 GAMMA1 HOLO-AMPK COMPLEX
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Zhou, X.E., Ke, J., Li, X., Wang, L., Gu, X., de Waal, P.W., Tan, M.H.E., Wang, D., Wu, D., Xu, H.E., Melcher, K.
Deposit date:2014-09-24
Release date:2014-12-10
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (4.58 Å)
Cite:Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4RQW
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CRYSTAL STRUCTURE OF MYC3 N-TERMINAL JAZ-BINDING DOMAIN [44-238] FROM ARABIDOPSIS
Descriptor:Transcription factor MYC3, CALCIUM ION
Authors:Ke, J., Zhang, F., Zhou, X.E., Brunzelle, J., Zhou, M., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2014-11-05
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4RRU
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MYC3 N-TERMINAL JAZ-BINDING DOMAIN[5-242] FROM ARABIDOPSIS
Descriptor:Transcription factor MYC3, CALCIUM ION
Authors:Ke, J., Zhang, F., Zhou, X.E., Brunzelle, J.S., Zhou, M., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2014-11-06
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4RS9
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STRUCTURE OF MYC3 N-TERMINAL JAZ-BINDING DOMAIN [44-238] IN COMPLEX WITH JAS MOTIF OF JAZ9
Descriptor:Transcription factor MYC3, Protein TIFY 7
Authors:Ke, J., Zhang, F., Zhou, X.E., Brunzelle, J.S., Zhou, M., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2014-11-07
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4YWC
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CRYSTAL STRUCTURE OF MYC3(5-242) FRAGMENT IN COMPLEX WITH JAZ9(218-239) PEPTIDE
Descriptor:Transcription factor MYC3, Protein TIFY 7
Authors:Ke, J., Zhang, F., Brunzelle, J.S., Xu, H.E., Melcher, K., He, S.Y.
Deposit date:2015-03-20
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4YZ6
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CRYSTAL STRUCTURE OF MYC3[44-238] FROM ARABIDOPSIS IN COMPLEX WITH JAZ1 PEPTIDE [200-221]
Descriptor:Transcription factor MYC3, Protein TIFY 10A
Authors:Ke, J., Zhang, F., Brunzelle, J., Xu, H.E., Melcher, K., HE, S.Y.
Deposit date:2015-03-24
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
4ZHE
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CRYSTAL STRUCTURE OF THE SEMET SUBSTITUTED TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) FROM RICE
Descriptor:ASPR2 protein
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-04-24
Release date:2015-08-05
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5C6Q
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CRYSTAL STRUCTURE OF THE APO TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) FROM RICE
Descriptor:ASPR2 protein, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-06-23
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.251 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5C6V
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) IN COMPLEX WITH ARABIDOPSIS NINJA PEPTIDE
Descriptor:ASPR2 protein, AFP homolog 2
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-06-23
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5C7E
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) IN COMPLEX WITH ARABIDOPSIS IAA10 PEPTIDE
Descriptor:ASPR2 protein, Auxin-responsive protein IAA10, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-06-24
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5C7F
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CRYSTAL STRUCTURE OF THE RICE TOPLESS RELATED PROTEIN 2 (TPR2) N-TERMINAL DOMAIN (1-209) IN COMPLEX WITH ARABIDOPSIS IAA1 PEPTIDE
Descriptor:ASPR2 protein, Auxin-responsive protein IAA1, ZINC ION
Authors:Ke, J., Ma, H., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2015-06-24
Release date:2015-08-05
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors.
Sci Adv, 1, 2015
5CM4
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CRYSTAL STRUCTURE OF HUMAN FRIZZLED 4 CYSTEINE-RICH DOMAIN (CRD)
Descriptor:Frizzled-4, N-ACETYL-D-GLUCOSAMINE
Authors:Ke, J., Parker, N., Gu, X., Zhang, C., Melcher, K., Xu, H.E.
Deposit date:2015-07-16
Release date:2015-08-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
5DGY
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CRYSTAL STRUCTURE OF RHODOPSIN BOUND TO VISUAL ARRESTIN
Descriptor:Endolysin,Rhodopsin,S-arrestin
Authors:Zhou, X.E., Gao, X., Kang, Y., He, Y., de Waal, P.W., Suino-Powell, K.M., Wang, M., Melcher, K., Xu, H.E.
Deposit date:2015-08-28
Release date:2016-03-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (7.7 Å)
Cite:X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.
Sci Data, 3, 2016
5DJ5
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CRYSTAL STRUCTURE OF RICE DWARF14 IN COMPLEX WITH SYNTHETIC STRIGOLACTONE GR24
Descriptor:Probable strigolactone esterase D14, (3E,3aR,8bS)-3-({[(2R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl]oxy}methylidene)-3,3a,4,8b-tetrahydro-2H-indeno[1,2-b]furan-2-one
Authors:Zhou, X.E., Zhao, L.-H., Yi, W., Wu, Z.-S., Liu, Y., Kang, Y., Hou, L., de Waal, P.W., Li, S., Jiang, Y., Melcher, K., Xu, H.E.
Deposit date:2015-09-01
Release date:2015-10-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3.
Cell Res., 25, 2015
5TDH
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THE CRYSTAL STRUCTURE OF THE DOMINANT NEGATIVE MUTANT G PROTEIN ALPHA(I)-1-BETA-1-GAMMA-2 G203A/A326S
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, P., Jia, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher, K., Xu, H.E., Jiang, Y.
Deposit date:2016-09-19
Release date:2016-11-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer
Acta Pharmacol.Sin., 37, 2016
5UWG
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THE CRYSTAL STRUCTURE OF FZ4-CRD IN COMPLEX WITH PALMITOLEIC ACID
Descriptor:Frizzled-4, PALMITOLEIC ACID, N-ACETYL-D-GLUCOSAMINE
Authors:Ke, J., DeBruine, Z.J., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2017-02-21
Release date:2017-06-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Genes Dev., 31, 2017
5V54
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CRYSTAL STRUCTURE OF 5-HT1B RECEPTOR IN COMPLEX WITH METHIOTHEPIN
Descriptor:5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Authors:Yin, W.C., Zhou, X.E., Yang, D., de Waal, P., Wang, M.T., Dai, A., Cai, X., Huang, C.Y., Liu, P., Yin, Y., Liu, B., Caffrey, M., Melcher, K., Xu, Y., Wang, M.W., Xu, H.E., Jiang, Y.
Deposit date:2017-03-13
Release date:2018-02-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist
Cell Discov, 2018
6C9F
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AMP-ACTIVATED PROTEIN KINASE BOUND TO PHARMACOLOGICAL ACTIVATOR R734
Descriptor:5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y., Zhou, X.E., Novick, S., Shaw, S.J., Li, Y., Hitoshi, Y., Brunzelle, J.S., Griffin, P.R., Xu, H.E., Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019