Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1MRN
DownloadVisualize
BU of 1mrn by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A)
Descriptor: MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ...
Authors:Haouz, A, Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Herdewijn, P, Van Calenbergh, S, Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
1MRS
DownloadVisualize
BU of 1mrs by Molmil
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE
Descriptor: 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, MAGNESIUM ION, SULFATE ION, ...
Authors:Haouz, A, Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Herdewijn, P, Van Calenbergh, S, Delarue, M.
Deposit date:2002-09-18
Release date:2003-01-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
8QKE
DownloadVisualize
BU of 8qke by Molmil
PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MH-13)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MH-13), ...
Authors:Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C.
Deposit date:2023-09-15
Release date:2024-03-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.504 Å)
Cite:Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Eur.J.Med.Chem., 269, 2024
8QKJ
DownloadVisualize
BU of 8qkj by Molmil
PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-133)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-133), ...
Authors:Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C.
Deposit date:2023-09-15
Release date:2024-03-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.767 Å)
Cite:Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Eur.J.Med.Chem., 269, 2024
8QKG
DownloadVisualize
BU of 8qkg by Molmil
PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-125)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-125), ...
Authors:Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C.
Deposit date:2023-09-15
Release date:2024-03-20
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.538 Å)
Cite:Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Eur.J.Med.Chem., 269, 2024
4USS
DownloadVisualize
BU of 4uss by Molmil
Populus trichocarpa glutathione transferase X1-1 (GHR1), complexed with glutathione
Descriptor: GLUTATHIONE, GLUTATHIONYL HYDROQUINONE REDUCTASE, PHOSPHATE ION
Authors:Lallement, P.A, Meux, E, Gualberto, J.M, Dumaracay, S, Favier, F, Didierjean, C, Saul, F, Haouz, A, Morel-Rouhier, M, Gelhaye, E, Rouhier, N, Hecker, A.
Deposit date:2014-07-13
Release date:2014-12-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glutathionyl-Hydroquinone Reductases from Poplar are Plastidial Proteins that Deglutathionylate Both Reduced and Oxidized Glutathionylated Quinones.
FEBS Lett., 589, 2015
6FDE
DownloadVisualize
BU of 6fde by Molmil
Crystal Structure of the HHD2 Domain of Whirlin : 3-helix conformation
Descriptor: Whirlin
Authors:Delhommel, F, Cordier, F, Saul, F, Haouz, A, Wolff, N.
Deposit date:2017-12-22
Release date:2018-08-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural plasticity of the HHD2 domain of whirlin.
FEBS J., 285, 2018
8S4H
DownloadVisualize
BU of 8s4h by Molmil
Crystal structure of scFv-1B6 in complex with rocuronium bromide
Descriptor: ScFv-1B6 VL, rocuronium, scFv-1B6 VH
Authors:Saul, F.A, Haouz, A, Bruhns, P.
Deposit date:2024-02-21
Release date:2024-09-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
Sci Transl Med, 16, 2024
8S4K
DownloadVisualize
BU of 8s4k by Molmil
Crystal structure of Fab-2B1 in complex with rocuronium
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fab-2B1 VH, Fab-2B1 VL, ...
Authors:Saul, F.A, Haouz, A, Bruhns, P.
Deposit date:2024-02-21
Release date:2024-09-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models.
Sci Transl Med, 16, 2024
6MFV
DownloadVisualize
BU of 6mfv by Molmil
Crystal structure of the Signal Transduction ATPase with Numerous Domains (STAND) protein with a tetratricopeptide repeat sensor PH0952 from Pyrococcus horikoshii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, tetratricopeptide repeat sensor PH0952
Authors:Lisa, M.N, Alzari, P.M, Haouz, A, Danot, O.
Deposit date:2018-09-12
Release date:2019-02-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor.
Nucleic Acids Res., 47, 2019
6ESC
DownloadVisualize
BU of 6esc by Molmil
Crystal structure of Pseudorabies virus glycoprotein B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein B, GLYCEROL
Authors:Backovic, M, Vaney, M.C, Rey, F.A, Haouz, A.
Deposit date:2017-10-20
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.
J.Virol., 92, 2018
5IKP
DownloadVisualize
BU of 5ikp by Molmil
Crystal structure of human brain glycogen phosphorylase bound to AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Glycogen phosphorylase, brain form, ...
Authors:Mathieu, C, Li de la Sierra-Gallay, I, Xu, X, Haouz, A, Rodrigues-Lima, F.
Deposit date:2016-03-03
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.
J.Biol.Chem., 291, 2016
5IKO
DownloadVisualize
BU of 5iko by Molmil
Crystal structure of human brain glycogen phosphorylase
Descriptor: Glycogen phosphorylase, brain form, HEXAETHYLENE GLYCOL, ...
Authors:Mathieu, C, Li de la Sierra-Gallay, I, Xu, X, Haouz, A, Rodrigues-Lima, F.
Deposit date:2016-03-03
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.
J.Biol.Chem., 291, 2016
1RFE
DownloadVisualize
BU of 1rfe by Molmil
Crystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis
Descriptor: hypothetical protein Rv2991
Authors:Benini, S, Haouz, A, Proux, F, Betton, J.M, Alzari, P, Dodson, G.G, Wilson, K.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-11-08
Release date:2004-12-28
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420binding protein with unknown function.
J. Struct. Biol., 2019
2Y75
DownloadVisualize
BU of 2y75 by Molmil
The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis
Descriptor: CHLORIDE ION, HTH-TYPE TRANSCRIPTIONAL REGULATOR CYMR, SULFATE ION
Authors:Shepard, W, Soutourina, O, Courtois, E, England, P, Haouz, A, Martin-Verstraete, I.
Deposit date:2011-01-28
Release date:2011-08-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into the Rrf2 Repressor Family - the Structure of Cymr, the Global Cysteine Regulator of Bacillus Subtilis.
FEBS J., 278, 2011
2CKD
DownloadVisualize
BU of 2ckd by Molmil
Crystal structure of ML2640 from Mycobacterium leprae
Descriptor: PUTATIVE S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE ML2640
Authors:Grana, M, Buschiazzo, A, Wehenkel, A, Haouz, A, Alzari, P.M.
Deposit date:2006-04-17
Release date:2007-05-29
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of M. Leprae Ml2640C Defines a Large Family of Putative S-Adenosylmethionine- Dependent Methyltransferases in Mycobacteria.
Protein Sci., 16, 2007
7BL7
DownloadVisualize
BU of 7bl7 by Molmil
Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (P21212 form)
Descriptor: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
Authors:Walter, P, Labesse, G, Haouz, A, Mechaly, A.E, Munier-Lehmann, H.
Deposit date:2021-01-18
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
7BIX
DownloadVisualize
BU of 7bix by Molmil
Crystal structure of UMPK from M. tuberculosis in complex with UDP and UTP (C2 form)
Descriptor: URIDINE 5'-TRIPHOSPHATE, URIDINE-5'-DIPHOSPHATE, Uridylate kinase
Authors:Labesse, G, Walter, P, Haouz, A, Mechaly, A.E, Munier-Lehmann, H.
Deposit date:2021-01-13
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Febs J., 289, 2022
2CDN
DownloadVisualize
BU of 2cdn by Molmil
Crystal structure of Mycobacterium tuberculosis adenylate kinase complexed with two molecules of ADP and Mg
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENYLATE KINASE, MAGNESIUM ION
Authors:Bellinzoni, M, Haouz, A, Grana, M, Munier-Lehmann, H, Alzari, P.M.
Deposit date:2006-01-25
Release date:2006-05-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of Mycobacterium Tuberculosis Adenylate Kinase in Complex with Two Molecules of Adp and Mg2+ Supports an Associative Mechanism for Phosphoryl Transfer.
Protein Sci., 15, 2006
4EO3
DownloadVisualize
BU of 4eo3 by Molmil
Peroxiredoxin Nitroreductase Fusion Enzyme
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Bacterioferritin comigratory protein/NADH dehydrogenase, FLAVIN MONONUCLEOTIDE, ...
Authors:Prosper, P, Haouz, A, Navaza, A, Jacquot, J.-P, Rouhier, N.
Deposit date:2012-04-13
Release date:2012-10-17
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.649 Å)
Cite:In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?
Antioxid Redox Signal, 18, 2013
4GUZ
DownloadVisualize
BU of 4guz by Molmil
Structure of the arylamine N-acetyltransferase from Mycobacterium abscessus
Descriptor: Probable arylamine n-acetyl transferase
Authors:Kubiak, X, Li de la Sierra-Gallay, I, Haouz, A, Weber, P, Rodrigues-Lima, F.
Deposit date:2012-08-30
Release date:2013-10-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition.
Acta Crystallogr.,Sect.D, 70, 2014
6Q42
DownloadVisualize
BU of 6q42 by Molmil
Crystal Structure of Human Pancreatic Phospholipase A2
Descriptor: CHLORIDE ION, Phospholipase A2
Authors:Saul, F, Haouz, A, Lambeau, G, Theze, J.
Deposit date:2018-12-05
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
J.Clin.Invest., 130, 2020
8COY
DownloadVisualize
BU of 8coy by Molmil
Structure of the catalytic domain of P. vivax Sub1 (triclinic crystal form) in complex with inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, SULFATE ION, ...
Authors:Martinez, M, Bouillon, A, Batista, F, Alzari, P.M, Barale, J.C, Haouz, A.
Deposit date:2023-03-01
Release date:2023-07-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.507 Å)
Cite:3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
Acta Crystallogr D Struct Biol, 79, 2023
8CP0
DownloadVisualize
BU of 8cp0 by Molmil
Structure of the catalytic domain of P. vivax Sub1 (trigonal crystal form)
Descriptor: CALCIUM ION, subtilisin
Authors:Martinez, M, Bouillon, A, Batista, F, Alzari, P.M, Barale, J.C, Haouz, A.
Deposit date:2023-03-01
Release date:2023-07-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.251 Å)
Cite:3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
Acta Crystallogr D Struct Biol, 79, 2023
8COZ
DownloadVisualize
BU of 8coz by Molmil
Structure of the catalytic domain of P. vivax Sub1 (triclinic crystal form)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, SULFATE ION, ...
Authors:Martinez, M, Bouillon, A, Batista, F, Alzari, P.M, Barale, J.C, Haouz, A.
Deposit date:2023-03-01
Release date:2023-07-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.438 Å)
Cite:3D structures of the Plasmodium vivax subtilisin-like drug target SUB1 reveal conformational changes to accommodate a substrate-derived alpha-ketoamide inhibitor.
Acta Crystallogr D Struct Biol, 79, 2023

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon