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6HHE
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CRYSTAL STRUCTURE OF THE MEDFLY ODORANT BINDING PROTEIN CCAPOBP22/CCAPOBP69A
Descriptor:Odorant binding protein OBP69a, SULFATE ION, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Falchetto, M., Ciossani, G., Nenci, S., Mattevi, A., Gasperi, G., Forneris, F.
Deposit date:2018-08-28
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (1.516 Å)
Cite:Structural and biochemical evaluation of Ceratitis capitata odorant-binding protein 22 affinity for odorants involved in intersex communication.
Insect Mol.Biol., 28, 2019
2X0L
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CRYSTAL STRUCTURE OF A NEURO-SPECIFIC SPLICING VARIANT OF HUMAN HISTONE LYSINE DEMETHYLASE LSD1.
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3 PEPTIDE, ...
Authors:Zibetti, C., Adamo, A., Binda, C., Forneris, F., Verpelli, C., Ginelli, E., Mattevi, A., Sala, C., Battaglioli, E.
Deposit date:2009-12-15
Release date:2010-03-02
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Alternative Splicing of the Histone Demethylase Lsd1/Kdm1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System.
J.Neurosci., 30, 2010
2XAF
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(+)-CIS-2- PHENYLCYCLOPROPYL-1-AMINE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAG
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH PARA-BROMO-(-)-TRANS- 2-PHENYLCYCLOPROPYL-1-AMINE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAH
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (+)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAJ
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH (-)-TRANS-2- PHENYLCYCLOPROPYL-1-AMINE
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAQ
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2584, 13B)
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAS
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CRYSTAL STRUCTURE OF LSD1-COREST IN COMPLEX WITH A TRANYLCYPROMINE DERIVATIVE (MC2580, 14E)
Descriptor:LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C., Valente, S., Romanenghi, M., Pilotto, S., Cirilli, R., Karytinos, A., Ciossani, G., Botrugno, O.A., Forneris, F., Tardugno, M., Edmondson, D.E., Minucci, S., Mattevi, A., Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
4A5W
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CRYSTAL STRUCTURE OF C5B6
Descriptor:COMPLEMENT C5, COMPLEMENT COMPONENT C6, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hadders, M.A., Bubeck, D., Forneris, F., Pangburn, M., Llorca, O., Lea, S.M., Gros, P.
Deposit date:2011-10-28
Release date:2012-03-14
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
Cell Rep., 1, 2012
4BSO
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CRYSTAL STRUCTURE OF R-SPONDIN 1 (FU1FU2) - NATIVE
Descriptor:R-SPONDIN-1, 1,2-ETHANEDIOL, CHLORIDE ION
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4BSP
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CRYSTAL STRUCTURE OF R-SPONDIN 1 (FU1FU2) - HOLMIUM SOAK
Descriptor:R-SPONDIN-1, HOLMIUM ATOM, SULFATE ION
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4BSR
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STRUCTURE OF THE ECTODOMAIN OF LGR5 IN COMPLEX WITH R-SPONDIN-1 (FU1FU2) IN P22121 CRYSTAL FORM
Descriptor:LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, R-SPONDIN-1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4BSS
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STRUCTURE OF THE ECTODOMAIN OF LGR5 IN COMPLEX WITH R-SPONDIN-1 (FU1FU2) IN P21 CRYSTAL FORM
Descriptor:LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, R-SPONDIN-1, N-ACETYL-D-GLUCOSAMINE
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4BST
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STRUCTURE OF THE ECTODOMAIN OF LGR5 IN COMPLEX WITH R-SPONDIN-1 (FU1FU2) IN P6122 CRYSTAL FORM
Descriptor:LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, R-SPONDIN-1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4BSU
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STRUCTURE OF THE ECTODOMAIN OF LGR5 IN COMPLEX WITH R-SPONDIN-1 (FU1FU2) IN C2 CRYSTAL FORM
Descriptor:LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, R-SPONDIN-1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Peng, W.C., de Lau, W., Forneris, F., Granneman, J.C.M., Huch, M., Clevers, H., Gros, P.
Deposit date:2013-06-11
Release date:2013-06-26
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Stem Cell Growth Factor R-Spondin 1 in Complex with the Ectodomain of its Receptor Lgr5.
Cell Rep., 3, 2013
4CDJ
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STRUCTURE OF ZNRF3 ECTODOMAIN
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, 1,2-ETHANEDIOL, FORMIC ACID
Authors:Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.
Plos One, 8, 2013
4CDK
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STRUCTURE OF ZNRF3-RSPO1
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE ZNRF3, R-SPONDIN-1
Authors:Peng, W.C., de Lau, W., Madoori, P.K., Forneris, F., Granneman, J.C.M., Clevers, H., Gros, P.
Deposit date:2013-11-01
Release date:2014-01-08
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.
Plos One, 8, 2013
5AJT
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CRYSTAL STRUCTURE OF LIGAND-FREE PHOSPHORIBOHYDROLASE LONELY GUY FROM CLAVICEPS PURPUREA
Descriptor:PHOSPHORIBOHYDROLASE LONELY GUY, 1,2-ETHANEDIOL, D(-)-TARTARIC ACID
Authors:Dzurova, L., Savino, S., Forneris, F.
Deposit date:2015-02-27
Release date:2015-06-03
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:The three-dimensional structure of "Lonely Guy" from Claviceps purpurea provides insights into the phosphoribohydrolase function of Rossmann fold-containing lysine decarboxylase-like proteins.
Proteins, 83, 2015
5AJU
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CRYSTAL STRUCTURE OF LIGAND-FREE PHOSPHORIBOHYDROXYLASE LONELY GUY FROM CLAVICEPS PURPUREA IN COMPLEX WITH PHOSPHORIBOSE
Descriptor:PHOSPHORIBOHYDROLASE LONELY GUY, 5-O-phosphono-beta-D-ribofuranose, SULFATE ION
Authors:Dzurova, L., Savino, S., Forneris, F.
Deposit date:2015-02-27
Release date:2015-06-03
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Three-Dimensional Structure of "Lonely Guy" from Claviceps Purpurea Provides Insights Into the Phosphoribohydrolase Function of Rossmann Fold-Containing Lysine Decarboxylase-Like Proteins.
Proteins, 83, 2015
5FYD
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STRUCTURAL AND BIOCHEMICAL INSIGHTS INTO 7BETA-HYDROXYSTEROID DEHYDROGENASE STEREOSELECTIVITY
Descriptor:OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY PROTEIN, GLYCEROL
Authors:Savino, S., Ferrandi, E., Forneris, F., Rovida, S., Riva, S., Monti, D., Mattevi, A.
Deposit date:2016-03-07
Release date:2016-04-06
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Biochemical Insights Into 7Beta-Hydroxysteroid Dehydrogenase Stereoselectivity.
Proteins, 84, 2016
5L3E
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LSD1-COREST1 IN COMPLEX WITH QUINAZOLINE-DERIVATIVE REVERSIBLE INHIBITOR
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
Deposit date:2016-04-10
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
5L3F
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LSD1-COREST1 IN COMPLEX WITH POLYMYXIN B
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, Polmyxin B, ...
Authors:Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
Deposit date:2016-04-10
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
5L3G
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LSD1-COREST1 IN COMPLEX WITH POLYMYXIN E (COLISTIN)
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, polymyxin E, ...
Authors:Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
Deposit date:2016-04-10
Release date:2016-09-21
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
5LBQ
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LSD1-COREST1 IN COMPLEX WITH QUINAZOLINE-DERIVATIVE REVERSIBLE INHIBITOR
Descriptor:Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Speranzini, V., Rotili, D., Ciossani, G., Pilotto, S., Forgione, M., Lucidi, A., Forneris, F., Velankar, S., Mai, A., Mattevi, A.
Deposit date:2016-06-16
Release date:2016-09-21
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Sci Adv, 2, 2016
5O32
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THE STRUCTURE OF COMPLEMENT COMPLEX
Descriptor:Complement C3, Complement factor H,Complement factor H, Complement factor I, ...
Authors:Xue, X., Wu, J., Forneris, F., Gros, P.
Deposit date:2017-05-23
Release date:2017-06-28
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (4.206209 Å)
Cite:Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Nat. Struct. Mol. Biol., 24, 2017