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3J79
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, LARGE SUBUNIT
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-02
Release date:2014-07-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J7A
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CRYO-EM STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTI-PROTOZOAN DRUG EMETINE, SMALL SUBUNIT
Descriptor:18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein uS2, ...
Authors:Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.
Deposit date:2014-06-03
Release date:2014-07-16
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
3J92
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STRUCTURE AND ASSEMBLY PATHWAY OF THE RIBOSOME QUALITY CONTROL COMPLEX
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Brown, A., Santhanam, B., Hegde, R.S.
Deposit date:2014-12-02
Release date:2015-01-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and Assembly Pathway of the Ribosome Quality Control Complex.
Mol.Cell, 57, 2015
4E40
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THE HAPTOGLOBIN-HEMOGLOBIN RECEPTOR OF TRYPANOSOMA CONGOLENSE
Descriptor:Putative uncharacterized protein
Authors:Higgins, M.K., Tkachenko, O., Brown, A., Reed, J., Carrington, M.
Deposit date:2012-03-11
Release date:2013-01-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Proc.Natl.Acad.Sci.USA, 110, 2013
5LZV
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STRUCTURE OF THE MAMMALIAN RIBOSOMAL TERMINATION COMPLEX WITH ACCOMMODATED ERF1(AAQ) AND ABCE1.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZW
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A TRUNCATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZX
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A UGA STOP CODON.
Descriptor:uL2, Ul3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZY
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L ASSEMBLED ON A POLYADENYLATED MRNA.
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.99 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5LZZ
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STRUCTURE OF THE MAMMALIAN RESCUE COMPLEX WITH PELOTA AND HBS1L (COMBINED)
Descriptor:uL2, uL3, uL4, ...
Authors:Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.
Deposit date:2016-10-02
Release date:2016-11-30
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
5MDV
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STRUCTURE OF ARFA AND RF2 BOUND TO THE 70S RIBOSOME (ACCOMMODATED STATE)
Descriptor:23S ribosomal RNA, 16S ribosomal RNA, 5S ribosomal RNA, ...
Authors:James, N.R., Brown, A., Gordiyenko, Y., Ramakrishnan, V.
Deposit date:2016-11-13
Release date:2016-12-14
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Translational termination without a stop codon.
Science, 354, 2016
5MDW
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STRUCTURE OF ARFA(A18T) AND RF2 BOUND TO THE 70S RIBOSOME (PRE-ACCOMMODATED STATE)
Descriptor:23S ribosomal RNA, 16S ribosomal RNA, 5S ribosomal RNA, ...
Authors:James, N.R., Brown, A., Gordiyenko, Y., Ramakrishnan, V.
Deposit date:2016-11-13
Release date:2016-12-14
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Translational termination without a stop codon.
Science, 354, 2016
5MDY
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STRUCTURE OF ARFA AND TTRF2 BOUND TO THE 70S RIBOSOME (PRE-ACCOMMODATED STATE)
Descriptor:23S ribosomal RNA, 16S ribosomal RNA, 5S ribosomal RNA, ...
Authors:James, N.R., Brown, A., Gordiyenko, Y., Ramakrishnan, V.
Deposit date:2016-11-13
Release date:2016-12-21
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Translational termination without a stop codon.
Science, 354, 2016
5MDZ
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STRUCTURE OF THE 70S RIBOSOME (EMPTY A SITE)
Descriptor:23S ribosomal RNA, 16S ribosomal RNA, 5S ribosomal RNA, ...
Authors:James, N.R., Brown, A., Gordiyenko, Y., Ramakrishnan, V.
Deposit date:2016-11-13
Release date:2016-12-14
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Translational termination without a stop codon.
Science, 354, 2016
5UMD
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STRUCTURE OF THE PLASMODIUM FALCIPARUM 80S RIBOSOME BOUND TO THE ANTIMALARIAL DRUG MEFLOQUINE
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Wong, W., Bai, X.-C., Brown, A., Scheres, S., Baum, J.
Deposit date:2017-01-27
Release date:2017-03-01
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis.
Nat Microbiol, 2, 2017
4EZJ
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(5-fluoro-1H-indol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZK
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4EZL
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POTENT AND SELECTIVE INHIBITORS OF PI3K-DELTA: OBTAINING ISOFORM SELECTIVITY FROM THE AFFINITY POCKET AND TRYPTOPHAN SHELF
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-(1-{[2-(2-aminopyrimidin-5-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
Authors:Murray, J.M.
Deposit date:2012-05-02
Release date:2013-04-17
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Bioorg.Med.Chem.Lett., 22, 2012
4J23
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LOW RESOLUTION CRYSTAL STRUCTURE OF THE FGFR2D2D3/FGF1/SR128545 COMPLEX
Descriptor:Fibroblast growth factor receptor 2, Fibroblast growth factor 1
Authors:Kudlinzki, D., Saxena, K., Sreeramulu, S., Schieborr, U., Dreyer, M., Schreuder, H., Schwalbe, H.
Deposit date:2013-02-04
Release date:2014-02-19
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.882 Å)
Cite:Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer Cell, 23, 2013
1B50
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NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES
Descriptor:MIP-1A
Authors:Waltho, J.P., Higgins, L.D., Craven, C.J., Tan, P., Dudgeon, T.
Deposit date:1999-01-11
Release date:1999-07-22
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
J.Biol.Chem., 274, 1999
1B53
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NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE
Descriptor:MIP-1A
Authors:Waltho, J.P., Higgins, L.D., Craven, C.J., Tan, P., Dudgeon, T.
Deposit date:1999-01-11
Release date:1999-07-22
Last modified:2012-02-22
Method:SOLUTION NMR
Cite:Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
J.Biol.Chem., 274, 1999
3JAK
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CRYO-EM STRUCTURE OF GTPGAMMAS-MICROTUBULE CO-POLYMERIZED WITH EB3 (MERGED DATASET WITH AND WITHOUT KINESIN BOUND)
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Microtubule-associated protein RP/EB family member 3, ...
Authors:Zhang, R., Nogales, E.
Deposit date:2015-06-16
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAL
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CRYO-EM STRUCTURE OF GMPCPP-MICROTUBULE CO-POLYMERIZED WITH EB3
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Microtubule-associated protein RP/EB family member 3, ...
Authors:Zhang, R., Nogales, E.
Deposit date:2015-06-16
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAR
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CRYO-EM STRUCTURE OF GDP-MICROTUBULE CO-POLYMERIZED WITH EB3
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Microtubule-associated protein RP/EB family member 3, ...
Authors:Zhang, R., Nogales, E.
Deposit date:2015-06-19
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAS
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CRYO-EM STRUCTURE OF DYNAMIC GDP-MICROTUBULE (14 PROTOFILAMENTS) DECORATED WITH KINESIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, R., Nogales, E.
Deposit date:2015-06-19
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015
3JAT
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CRYO-EM STRUCTURE OF GMPCPP-MICROTUBULE (14 PROTOFILAMENTS) DECORATED WITH KINESIN
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, R., Nogales, E.
Deposit date:2015-06-20
Release date:2015-08-12
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.
Cell(Cambridge,Mass.), 162, 2015