3DAR

Crystal structure of D2 domain from human FGFR2

Summary for 3DAR

Related1E0O 1WVZ
DescriptorFibroblast growth factor receptor 2 (2 entities in total)
Functional Keywordsimmunoglobulin fold, atp-binding, craniosynostosis, disease mutation, ectodermal dysplasia, glycoprotein, heparin-binding, immunoglobulin domain, kinase, lacrimo-auriculo-dento-digital syndrome, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802
Total number of polymer chains2
Total molecular weight24367.71
Authors
Brown, A.,Blundell, T.L. (deposition date: 2008-05-30, release date: 2008-06-10, Last modification date: 2014-09-10)
Primary citation
Brown, A.,Blundell, T.L.
Crystal structure of the FGFR2 D2 domain
To be Published,
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2522003.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

Molmil generated image of 3dar
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Molmil generated image of 3dar
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3dar.pdb1.gz [18.53 KB])
Coordinate files for Biological unit (3dar.pdb2.gz [18.5 KB])