Author results

4V06
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CRYSTAL STRUCTURE OF HUMAN TRYPTOPHAN HYDROXYLASE 2 (TPH2), CATALYTIC DOMAIN
Descriptor:TRYPTOPHAN 5-HYDROXYLASE 2, IMIDAZOLE, FE (III) ION
Authors:Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-09-11
Release date:2014-10-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain
To be Published
5L76
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CRYSTAL STRUCTURE OF HUMAN AMINOADIPATE SEMIALDEHYDE SYNTHASE, SACCHAROPINE DEHYDROGENASE DOMAIN (IN APO FORM)
Descriptor:Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Pena, I.A., Rembeza, E., Strain-Damerell, C., Chalk, R., Borkowska, O., Goubin, S., Velupillai, S., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Arruda, P., Yue, W.W.
Deposit date:2016-06-02
Release date:2017-05-10
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in apo form)
To Be Published
5MPO
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CRYSTAL STRUCTURE OF HUMAN MOLYBDOPTERIN SYNTHASE COMPLEX
Descriptor:Molybdopterin synthase sulfur carrier subunit, Molybdopterin synthase catalytic subunit
Authors:Kopec, J., Bailey, H., Fitzpatrick, F., Strain-Damerell, C., Oberholzer, A.E., Williams, E., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-12-16
Release date:2016-12-28
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of human molybdopterin synthase complex
To Be Published
6G4Q
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STRUCTURE OF HUMAN ADP-FORMING SUCCINYL-COA LIGASE COMPLEX SUCLG1-SUCLA2
Descriptor:Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, Succinate--CoA ligase [ADP-forming] subunit beta, ...
Authors:Bailey, H.J., Shrestha, L., Rembeza, E., Sorrell, F.J., Newman, J., Strain-Damerell, C., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2018-03-28
Release date:2018-04-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2
To Be Published
6GQD
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STRUCTURE OF HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE (GALT), WITH CRYSTALLIZATION EPITOPE MUTATIONS A21Y:A22T:T23P:R25L
Descriptor:Galactose-1-phosphate uridylyltransferase, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Fairhead, M., Strain-Damerell, C., Kopec, J., Bezerra, G.A., Zhang, M., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2018-06-07
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.523 Å)
Cite:Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L
To Be Published
1ZSV
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CRYSTAL STRUCTURE OF HUMAN NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE
Descriptor:NADP-dependent leukotriene B4 12-hydroxydehydrogenase, CHLORIDE ION
Authors:Turnbull, A.P., Johansson, C., Savitsky, P., Guo, K., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-05-25
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase
To be Published
1ZX1
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HUMAN QUINONE OXIDOREDUCTASE 2 (NQO2) IN COMPLEX WITH THE CYTOSTATIC PRODRUG CB1954
Descriptor:NRH dehydrogenase [quinone] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Jansson, A., Wu, X., Kavanagh, K., Kerr, D., Knox, R., Walton, R., Gunther, U., Ludwig, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-06-06
Release date:2005-06-14
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
To be Published
2A98
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE C
Descriptor:Inositol 1,4,5-trisphosphate 3-kinase C, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE
Authors:Hallberg, B.M., Ogg, D., Ehn, M., Graslund, S., Hammarstrom, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Persson, C., Sagemark, J., Schuler, H., Stenmark, P., Thorsell, A.-G., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Structural Genomics Consortium (SGC)
Deposit date:2005-07-11
Release date:2005-07-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C
To be Published
2AW5
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CRYSTAL STRUCTURE OF A HUMAN MALIC ENZYME
Descriptor:NADP-dependent malic enzyme
Authors:Papagrigoriou, E., Berridge, G., Smee, C., Bray, J., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Gileadi, O., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2005-08-31
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a human malic enzyme
To be published
2C0C
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STRUCTURE OF THE MGC45594 GENE PRODUCT
Descriptor:ZINC BINDING ALCOHOL DEHYDROGENASE, DOMAIN CONTAINING 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bunkoczi, G., Shafqat, N., Guo, K., Smee, C., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Gileadi, O., von Delft, F., Oppermann, U.
Deposit date:2005-08-30
Release date:2005-09-12
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Structure of Mgc45594 Gene Product
To be Published
2C2H
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CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP
Descriptor:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3, GUANOSINE-5'-DIPHOSPHATE, CALCIUM ION, ...
Authors:Debreczeni, J.E., Yang, X., Zao, Y., Elkins, J., Gileadi, C., Burgess, N., Colebrook, S., Gileadi, O., Fedorov, O., Bunkoczi, G., von Delft, F., Doyle, D., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A.
Deposit date:2005-09-29
Release date:2005-10-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Human Rac3 in Complex with Gdp
To be Published
2C4K
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CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE- ASSOCIATED PROTEIN 39 (PAP39)
Descriptor:PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 1, SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Kursula, P., Stenmark, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Nordlund, P.
Deposit date:2005-10-20
Release date:2005-10-24
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of Human Phosphoribosylpyrophosphate Synthetase-Associated Protein 39 (Pap39)
To be Published
2C9H
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STRUCTURE OF MITOCHONDRIAL BETA-KETOACYL SYNTHASE
Descriptor:MITOCHONDRIAL BETA-KETOACYL SYNTHASE, NICKEL (II) ION
Authors:Bunkoczi, G., Wu, X., Smee, C., Gileadi, O., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., von Delft, F., Oppermann, U.
Deposit date:2005-12-12
Release date:2005-12-13
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Mitochondrial Beta-Ketoacyl Synthase
To be Published
2CFY
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CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1
Descriptor:THIOREDOXIN REDUCTASE 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Debreczeni, J.E., Johansson, C., Kavanagh, K., Savitsky, P., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U.
Deposit date:2006-02-26
Release date:2006-03-09
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human Thioredoxin Reductase 1
To be Published
2CLP
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CRYSTAL STRUCTURE OF HUMAN AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3
Descriptor:AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION
Authors:Debreczeni, J.E., Marsden, B.D., Johansson, C., Kavanagh, K., Guo, K., Smee, C., Gileadi, O., Turnbull, A., Papagrigoriou, E., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Oppermann, U.
Deposit date:2006-04-28
Release date:2006-05-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
To be Published
2ERY
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THE CRYSTAL STRUCTURE OF THE RAS RELATED PROTEIN RRAS2 (RRAS2) IN THE GDP BOUND STATE
Descriptor:Ras-related protein R-Ras2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Salah, E., Schoch, G., Turnbull, A., Papagrigoriou, E., Soundararajan, M., Burgess, N., Elkins, J., Gileadi, C., Gileadi, O., von Delft, F., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2005-10-25
Release date:2005-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state
To be Published
2EXE
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CRYSTAL STRUCTURE OF THE PHOSPHORYLATED CLK3
Descriptor:Dual specificity protein kinase CLK3
Authors:Papagrigoriou, E., Rellos, P., Das, S., Bullock, A., Ball, L.J., Turnbull, A., Savitsky, P., Fedorov, O., Johansson, C., Ugochukwu, E., Sobott, F., von Delft, F., Edwards, A., Sundstrom, M., Weigelt, J., Arrowsmith, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-11-08
Release date:2005-11-15
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of the phosphorylated CLK3
TO BE PUBLISHED
2F6Q
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THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2 ENOYL COA ISOMERASE (PECI)
Descriptor:Peroxisomal 3,2-trans-enoyl-CoA isomerase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Turnbull, A., Lukacik, P., Shafqat, N., Smee, C., Berridge, G., Guo, K., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-11-29
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
To be Published
2F73
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CRYSTAL STRUCTURE OF HUMAN FATTY ACID BINDING PROTEIN 1 (FABP1)
Descriptor:Fatty acid-binding protein, liver
Authors:Kursula, P., Thorsell, A.G., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Holmberg Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., van den Berg, S., Weigelt, J., Hallberg, B.M., Structural Genomics Consortium (SGC)
Deposit date:2005-11-30
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human FABP1
To be Published
2FIM
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STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN TUBBY-LIKE PROTEIN 1
Descriptor:Tubby related protein 1, 3-(N,N-DIMETHYLOCTYLAMMONIO)PROPANESULFONATE, SULFATE ION
Authors:Hallberg, B.M., Ogg, D., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Persson, C.
Deposit date:2005-12-29
Release date:2006-02-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the C-terminal domain of Human Tubby-like protein 1
To be published
2FN4
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THE CRYSTAL STRUCTURE OF HUMAN RAS-RELATED PROTEIN, RRAS, IN THE GDP-BOUND STATE
Descriptor:Ras-related protein R-Ras, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Turnbull, A.P., Elkins, J.M., Gileadi, C., Burgess, N., Salah, E., Papagrigoriou, E., Debreczeni, J., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-01-10
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human Ras-related protein, RRAS, in the GDP-bound state
To be Published
2FVL
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CRYSTAL STRUCTURE OF HUMAN 3-ALPHA HYDROXYSTEROID/DIHYDRODIOL DEHYDROGENASE (AKR1C4) COMPLEXED WITH NADP+
Descriptor:Aldo-keto reductase family 1, member C4, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Ugochukwu, E., Smee, C., Guo, K., Lukacik, P., Kavanagh, K., Debreczeni, J.E., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-01-31
Release date:2006-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human 3-alpha hydroxysteroid/dihydrodiol dehydrogenase (AKR1C4) complexed with NADP+
To be Published
2G0N
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THE CRYSTAL STRUCTURE OF THE HUMAN RAC3 IN COMPLEX WITH GDP AND CHLORIDE
Descriptor:Ras-related C3 botulinum toxin substrate 3, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Ugochukwu, E., Yang, X., Zao, Y., Elkins, J., Gileadi, C., Burgess, N., Colebrook, S., Gileadi, O., Fedorov, O., Bunkoczi, G., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-02-13
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of the Human RAC3 in complex with GDP and Chloride
To be Published
2G7R
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X-RAY STRUCTURE OF THE DEATH DOMAIN OF THE HUMAN MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1
Descriptor:Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Walker, J.R., Wybenga-Groot, L., Newman, E.M., Finerty Jr., P.J., Butler-Cole, C., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-02-28
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structure of the death domain of the human mucosa associated lymphoid tissue lymphoma translocation protein 1
To be Published
2GJS
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THE CRYSTAL STRUCTURE OF HUMAN RRAD IN COMPLEX WITH GDP
Descriptor:GTP-binding protein RAD, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Turnbull, A.P., Yang, X., Soundararajan, M., Schoch, G., Debreczeni, J., Elkins, J.M., Gileadi, C., Berridge, G., Pantic, N., Burgess, N., Smee, C.E.A., Bray, J., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human RRAD in complex with GDP
To be Published