Author results

5ZR1
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SACCHAROMYCES CEREVISIAE ORIGIN RECOGNITION COMPLEX BOUND TO A 72-BP ORIGIN DNA CONTAINING ACS AND B1 ELEMENT
Descriptor:Origin recognition complex subunit 1, Origin recognition complex subunit 2, Origin recognition complex subunit 3, ...
Authors:Li, N., Lam, W.H., Zhai, Y., Cheng, J., Cheng, E., Zhao, Y., Gao, N., Tye, B.K.
Deposit date:2018-04-21
Release date:2018-07-11
Last modified:2018-07-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of the origin recognition complex bound to DNA replication origin.
Nature, 559, 2018
5ZRV
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STRUCTURE OF HUMAN MITOCHONDRIAL TRIFUNCTIONAL PROTEIN, OCTAMER
Descriptor:Trifunctional enzyme subunit alpha, mitochondrial, Trifunctional enzyme subunit beta
Authors:Liang, K., Li, N., Dai, J., Wang, X., Liu, P., Chen, X., Wang, C., Gao, N., Xiao, J.
Deposit date:2018-04-25
Release date:2018-06-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Cryo-EM structure of human mitochondrial trifunctional protein
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5YDZ
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 1
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE1
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL: STATE 2
Descriptor:Mucolipin-1
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE2
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MAMMALIAN ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO AMPHIPOL
Descriptor:mammalian endo-lysosomal TRPML1 channel
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-12-27
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
5YE5
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STRUCTURE OF ENDO-LYSOSOMAL TRPML1 CHANNEL INSERTING INTO NANODISC
Descriptor:mammalian endo-lysosomal TRPML1 channel, N-ACETYL-D-GLUCOSAMINE
Authors:Yang, M., Gao, N.
Deposit date:2017-09-15
Release date:2017-11-15
Last modified:2017-11-22
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism
Protein Cell, 8, 2017
2YKR
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30S RIBOSOMAL SUBUNIT WITH RSGA BOUND IN THE PRESENCE OF GMPPNP
Descriptor:16S RRNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ...
Authors:Guo, Q., Yuan, Y., Xu, Y., Feng, B., Liu, L., Chen, K., Lei, J., Gao, N.
Deposit date:2011-05-30
Release date:2011-08-24
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Structural Basis for the Function of a Small Gtpase Rsga on the 30S Ribosomal Subunit Maturation Revealed by Cryoelectron Microscopy.
Proc.Natl.Acad.Sci.USA, 108, 2011
3J28
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-13
Method:ELECTRON MICROSCOPY (12.9 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J29
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-13
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2A
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2014-10-22
Method:ELECTRON MICROSCOPY (13.1 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2B
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-13
Method:ELECTRON MICROSCOPY (13.6 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2C
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA head domain, 16S rRNA body domain
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-13
Method:ELECTRON MICROSCOPY (13.2 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2D
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-06
Method:ELECTRON MICROSCOPY (18.700001 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2E
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-06
Method:ELECTRON MICROSCOPY (15.3 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process
Nucleic Acids Res., 41, 2013
3J2F
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-06
Method:ELECTRON MICROSCOPY (17.6 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
3J2G
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-06
Method:ELECTRON MICROSCOPY (16.5 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
3J2H
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DISSECTING THE IN VIVO ASSEMBLY OF THE 30S RIBOSOMAL SUBUNIT REVEALS THE ROLE OF RIMM
Descriptor:16S rRNA
Authors:Guo, Q., Goto, S., Chen, Y., Muto, A., Himeno, H., Deng, H., Lei, J., Gao, N.
Deposit date:2012-09-28
Release date:2013-01-16
Last modified:2013-03-13
Method:ELECTRON MICROSCOPY (18.799999 Å)
Cite:Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic Acids Res., 41, 2013
3JBU
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MECHANISMS OF RIBOSOME STALLING BY SECM AT MULTIPLE ELONGATION STEPS
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, J., Pan, X.J., Yan, K.G., Sun, S., Gao, N., Sui, S.F.
Deposit date:2015-10-16
Release date:2016-01-27
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Mechanisms of ribosome stalling by SecM at multiple elongation steps
Elife, 4, 2015
3JBV
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MECHANISMS OF RIBOSOME STALLING BY SECM AT MULTIPLE ELONGATION STEPS
Descriptor:RNA (1530-MER), 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Zhang, J., Pan, X.J., Yan, K.G., Sun, S., Gao, N., Sui, S.F.
Deposit date:2015-10-16
Release date:2016-01-27
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Mechanisms of ribosome stalling by SecM at multiple elongation steps
Elife, 4, 2015
3JCD
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STRUCTURE OF ESCHERICHIA COLI EF4 IN POSTTRANSLOCATIONAL RIBOSOMES (POST EF4)
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCE
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STRUCTURE OF ESCHERICHIA COLI EF4 IN PRETRANSLOCATIONAL RIBOSOMES (PRE EF4)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2017-02-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCT
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CRYO-EM STRUCTURE OF EUKARYOTIC PRE-60S RIBOSOMAL SUBUNITS
Descriptor:60S ribosomal protein L2-A, 60S ribosomal protein L3, 60S ribosomal protein L4-A, ...
Authors:Wu, S., Kumcuoglu, B., Yan, K.G., Brown, H., Zhang, Y.X., Tan, D., Gamalinda, M., Yuan, Y., Li, Z.F., Jakovljevic, J., Ma, C.Y., Lei, J.L., Dong, M.Q., Woolford Jr., J.L., Gao, N.
Deposit date:2016-03-09
Release date:2016-06-01
Last modified:2017-02-01
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
Nature, 534, 2016
3PN1
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NOVEL BACTERIAL NAD+-DEPENDENT DNA LIGASE INHIBITORS WITH BROAD SPECTRUM POTENCY AND ANTIBACTERIAL EFFICACY IN VIVO
Descriptor:DNA ligase, 2-(butylsulfanyl)adenosine, 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
Authors:Mills, S., Eakin, A., Buurman, E., Newman, J., Gao, N., Huynh, H., Johnson, K., Lahiri, S., Shapiro, A., Walkup, G., Wei, Y., Stokes, S.
Deposit date:2010-11-18
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo.
Antimicrob.Agents Chemother., 55, 2011
4LH6
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CRYSTAL STRUCTURE OF A LIGA INHIBITOR
Descriptor:DNA ligase, 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ...
Authors:Benenato, K., Wang, H., Mcguire, H.M., Davis, H., Gao, N., Prince, D.B., Jahic, H., Stokes, S.S., Boriack-Sjodin, P.A.
Deposit date:2013-06-30
Release date:2013-12-25
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.
Bioorg.Med.Chem.Lett., 24, 2014
4WF1
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CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO NEGAMYCIN.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Olivier, N.B., Altman, R.B., Noeske, J., Basarab, G.S., Code, E., Ferguson, A.D., Gao, N., Huang, J., Juette, M.F., Livchak, S., Miller, M.D., Prince, D.B., Cate, J.H.D., Buurman, E.T., Blanchard, S.C.
Deposit date:2014-09-11
Release date:2014-11-05
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc.Natl.Acad.Sci.USA, 111, 2014