Author results

6BWX
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 1
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BX0
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 2
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.79 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6BX1
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ATOMIC RESOLUTION STRUCTURE OF HUMAN BUFAVIRUS 3
Descriptor:VP2
Authors:Mietzsch, M., Agbandje-McKenna, M.
Deposit date:2017-12-15
Release date:2018-01-24
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses, 10, 2018
6CBE
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ATOMIC STRUCTURE OF A RATIONALLY ENGINEERED GENE DELIVERY VECTOR, AAV2.5
Descriptor:Capsid protein VP1
Authors:Burg, M., Rosebrough, C., Drouin, L., Bennett, A., Mietzsch, M., Chipman, P., McKenna, R., Sousa, D., Potter, M., Byrne, B., Kozyreva, O.G., Samulski, R.J., Agbandje-McKenna, M.
Deposit date:2018-02-02
Release date:2018-05-30
Last modified:2018-08-29
Method:ELECTRON MICROSCOPY (2.78 Å)
Cite:Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
6E9D
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SUB-2 ANGSTROM EWALD CURVATURE-CORRECTED SINGLE-PARTICLE CRYO-EM RECONSTRUCTION OF AAV-2 L336C
Descriptor:Capsid protein VP1
Authors:Tan, Y.Z., Aiyer, S., Mietzsch, M., Hull, J.A., McKenna, R., Baker, T.S., Agbandje-McKenna, M., Lyumkis, D.
Deposit date:2018-07-31
Release date:2018-08-15
Last modified:2018-09-19
Method:ELECTRON MICROSCOPY (1.86 Å)
Cite:Sub-2 angstrom Ewald curvature corrected structure of an AAV2 capsid variant.
Nat Commun, 9, 2018
6NXE
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CRYO-EM RECONSTRUCTION OF PROTEASE-ACTIVATEABLE ADENO-ASSOCIATED VIRUS 9 (AAV9-L001)
Descriptor:Capsid protein VP1
Authors:Bennett, A.B., Agbandje-Mckenna, M.
Deposit date:2019-02-08
Release date:2019-03-13
Last modified:2019-03-20
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
Mol. Ther., 27, 2019
1IJS
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CPV (STRAIN D) MUTANT A300D, COMPLEX (VIRAL COAT/DNA), VP2, PH=7.5, T=4 DEGREES C
Descriptor:DNA (5'-D(*CP*CP*AP*CP*CP*CP*CP*AP*A)-3'), DNA (5'-D(*AP*C)-3'), PROTEIN (PARVOVIRUS COAT PROTEIN)
Authors:Llamas-Saiz, A.L., Agbandje-McKenna, M., Parker, J.S.L., Wahid, A.T.M., Parrish, C.R., Rossmann, M.G.
Deposit date:1996-09-12
Release date:1996-12-23
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structural analysis of a mutation in canine parvovirus which controls antigenicity and host range.
Virology, 225, 1996
3NTT
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STRUCTURAL INSIGHTS OF ADENO-ASSOCIATED VIRUS 5. A GENE THERAPY VECTOR FOR CYSTIC FIBROSIS
Descriptor:Capsid protein, GLYCEROL, SODIUM ION
Authors:Govindasamy, L., DiMattia, M., Chiorini, J.A., McKenna, R., Muzyczka, N., Agbandje-McKenna, M.
Deposit date:2010-07-05
Release date:2011-12-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Structural insights into adeno-associated virus serotype 5.
J.Virol., 87, 2013
5IPI
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STRUCTURE OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
Descriptor:Capsid protein VP1
Authors:Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
Deposit date:2016-03-09
Release date:2016-07-20
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
5IPK
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STRUCTURE OF THE R432A VARIANT OF ADENO-ASSOCIATED VIRUS TYPE 2 VLP
Descriptor:Capsid protein VP1
Authors:Drouin, L.M., Lins, B., Janssen, M.E., Bennet, A., Chipman, P., McKenna, R., Chen, W., Muzyczka, N., Cardone, G., Baker, T.S., Agbandje-McKenna, M.
Deposit date:2016-03-09
Release date:2016-07-20
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
J.Virol., 90, 2016
6B9Q
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SINGLE PARTICLE CRYO-EM STRUCTURE DETERMINATION OF THE LUIII CAPSID PROTEIN
Descriptor:Capsid protein VP2
Authors:Pittman, N.C., Agbandje-McKenna, M.
Deposit date:2017-10-11
Release date:2017-11-15
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.
Viruses, 9, 2017
1LCU
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POLYLYSINE INDUCES AN ANTIPARALLEL ACTIN DIMER THAT NUCLEATES FILAMENT ASSEMBLY: CRYSTAL STRUCTURE AT 3.5 A RESOLUTION
Descriptor:Actin, alpha skeletal muscle, CALCIUM ION, ...
Authors:Bubb, M.R., Govindasamy, L., Yarmola, E.G., Vorobiev, S.M., Almo, S.C., Somasundaram, T., Chapman, M.S., Agbandje-Mckenna, M., Mckenna, R.
Deposit date:2002-04-06
Release date:2002-05-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
J.Biol.Chem., 277, 2002
1NM8
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STRUCTURE OF HUMAN CARNITINE ACETYLTRANSFERASE: MOLECULAR BASIS FOR FATTY ACYL TRANSFER
Descriptor:Carnitine O-acetyltransferase
Authors:Wu, D., Govindasamy, L., Lian, W., Gu, Y., Kukar, T., Agbandje-McKenna, M., McKenna, R.
Deposit date:2003-01-09
Release date:2003-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Human Carnitine Acetyltransferase. Molecular Basis for Fatty Acyl Transfer
J.Biol.Chem., 278, 2003
1RDW
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ACTIN CRYSTAL DYNAMICS: STRUCTURAL IMPLICATIONS FOR F-ACTIN NUCLEATION, POLYMERIZATION AND BRANCHING MEDIATED BY THE ANTI-PARALLEL DIMER
Descriptor:Actin, alpha skeletal muscle, MAGNESIUM ION, ...
Authors:Reutzel, R., Yoshioka, C., Govindasamy, L., Yarmola, E.G., Agbandje-Mckenna, M., Bubb, M.R., Mckenna, R.
Deposit date:2003-11-06
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
J.Struct.Biol., 146, 2004
1RFQ
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ACTIN CRYSTAL DYNAMICS: STRUCTURAL IMPLICATIONS FOR F-ACTIN NUCLEATION, POLYMERIZATION AND BRANCHING MEDIATED BY THE ANTI-PARALLEL DIMER
Descriptor:Actin, alpha skeletal muscle, MAGNESIUM ION, ...
Authors:Reutzel, R., Yoshioka, C., Govindasamy, L., Yarmola, E.G., Agbandje-McKenna, M., Bubb, M.R., McKenna, R.
Deposit date:2003-11-10
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
J.Struct.Biol., 146, 2004
1S5O
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STRUCTURAL AND MUTATIONAL CHARACTERIZATION OF L-CARNITINE BINDING TO HUMAN CARNITINE ACETYLTRANSFERASE
Descriptor:carnitine acetyltransferase isoform 2, CARNITINE
Authors:Govindasamy, L., Kukar, T., Lian, W., Pedersen, B., Gu, Y., Agbandje-Mckenna, M., Jin, S., Mckenna, R., Wu, D.
Deposit date:2004-01-21
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase.
J.Struct.Biol., 146, 2004
1T1U
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STRUCTURAL INSIGHTS AND FUNCTIONAL IMPLICATIONS OF CHOLINE ACETYLTRANSFERASE
Descriptor:Choline O-acetyltransferase
Authors:Govindasamy, L., Pedersen, B., Lian, W., Kukar, T., Gu, Y., Jin, S., Agbandje-McKenna, M., Wu, D.
Deposit date:2004-04-18
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insights and functional implications of choline acetyltransferase
J.Struct.Biol., 148, 2004
1Z93
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HUMAN CARBONIC ANHYDRASE III:STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
1Z97
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HUMAN CARBONIC ANHYDRASE III: STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER.
Descriptor:Carbonic anhydrase III, ZINC ION
Authors:Duda, D.M., Tu, C., Fisher, S.Z., An, H., Yoshioka, C., Govindasamy, L., Laipis, P.J., Agbandje-McKenna, M., Silverman, D.N., McKenna, R.
Deposit date:2005-03-31
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and Proton Transfer
Biochemistry, 44, 2005
2ANL
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X-RAY CRYSTAL STRUCTURE OF THE ASPARTIC PROTEASE PLASMEPSIN 4 FROM THE MALARIAL PARASITE PLASMODIUM MALARIAE BOUND TO AN ALLOPHENYLNORSTATINE BASED INHIBITOR
Descriptor:plasmepsin IV, (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide
Authors:Clemente, J.C., Govindasamy, L., Madabushi, A., Fisher, S.Z., Moose, R.E., Yowell, C.A., Hidaka, K., Kimura, T., Hayashi, Y., Kiso, Y., Agbandje-McKenna, M., Dame, J.B., Dunn, B.M., McKenna, R.
Deposit date:2005-08-11
Release date:2006-04-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta Crystallogr.,Sect.D, 62, 2006
2AQU
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STRUCTURE OF HIV-1 PROTEASE BOUND TO ATAZANAVIR
Descriptor:HIV-1 Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5,6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER
Authors:Clemente, J.C., Coman, R.M., Thiaville, M.M., Janka, L.K., Jeung, J.A., Nukoolkarn, S., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Leelamanit, W., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-08-18
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry, 45, 2006
2B60
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO RITONAVIR
Descriptor:Gag-Pol polyprotein, GLYCEROL, RITONAVIR
Authors:Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-09-29
Release date:2006-11-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
2B7Z
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STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO INDINAVIR
Descriptor:HIV-1 protease, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:Clemente, J.C., Stow, L.R., Janka, L.K., Jeung, J.A., Desai, K.A., Govindasamy, L., Agbandje-McKenna, M., McKenna, R., Goodenow, M.M., Dunn, B.M.
Deposit date:2005-10-05
Release date:2006-11-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:In vivo, kinetic, and structural analysis of the development of ritonavir resistance
To be Published
2EU2
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006
2EU3
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HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, 1-(5-AMINO-1,3,4-THIADIAZOL-2-YL)-1,1-DIFLUOROMETHANESULFONAMIDE
Authors:Fisher, S.Z., Govindasamy, L., Boyle, N., Agbandje-McKenna, M., Silverman, D.N., Blackburn, G.M., McKenna, R.
Deposit date:2005-10-28
Release date:2006-07-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta Crystallogr.,Sect.F, 62, 2006