Author results

4LSU
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-PG20 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120
Descriptor:HIV-1 CLADE A/E STRAIN 93TH057 GP120, HEAVY CHAIN OF ANTIBODY VRC-PG20, LIGHT CHAIN OF ANTIBODY VRC-PG20, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4LSV
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY 3BNC117 IN COMPLEX WITH HIV-1 CLADE C C1086 GP120
Descriptor:envelope glycoprotein GP120, HEAVY CHAIN OF ANTIBODY 3BNC117, LIGHT CHAIN OF ANTIBODY 3BNC117, ...
Authors:Zhou, T., Moquin, S., Kwong, P.D.
Deposit date:2013-07-23
Release date:2013-08-21
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Immunity, 39, 2013
4NM6
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CRYSTAL STRUCTURE OF TET2-DNA COMPLEX
Descriptor:Methylcytosine dioxygenase TET2, 5'-D(*AP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*T)-3', ZINC ION, ...
Authors:Hu, L., Li, Z., Cheng, J., Rao, Q., Gong, W., Liu, M., Wang, P., Xu, Y.
Deposit date:2013-11-14
Release date:2013-12-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation.
Cell(Cambridge,Mass.), 155, 2013
4OLU
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CRYSTAL STRUCTURE OF ANTIBODY VRC07 IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.202 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLV
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54F IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLW
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54H IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.709 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLX
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54L IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLY
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54R IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OLZ
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54W IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OM0
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-G54Y IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.289 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
4OM1
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CRYSTAL STRUCTURE OF ANTIBODY VRC07-I30Q, G54W, S58N IN COMPLEX WITH CLADE A/E 93TH057 HIV-1 GP120 CORE
Descriptor:Envelope glycoprotein gp160, Antigen binding fragment of heavy chain: Antibody VRC01, Antigen binding fragment of light chain: Antibody VRC01, ...
Authors:Kwon, Y.D., Kwong, P.D.
Deposit date:2014-01-25
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.131 Å)
Cite:Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo.
J.Virol., 88, 2014
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5E73
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CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH ACETYLINDOLE COMPOUND UZH47
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide
Authors:Lolli, G., Spiliotopoulos, D., Unzue, A., Nevado, C., Caflisch, A.
Deposit date:2015-10-11
Release date:2015-10-28
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
5E74
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CRYSTAL STRUCTURE OF BAZ2B BROMODOMAIN IN COMPLEX WITH ACETYLINDOLE COMPOUND UZH50
Descriptor:Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)-3-(trifluoromethyl)benzamide
Authors:Lolli, G., Spiliotopoulos, D., Dolbois, A., Nevado, C., Caflisch, A.
Deposit date:2015-10-11
Release date:2015-10-21
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (1.783 Å)
Cite:The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
5QJ0
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ETHYL(METHYLSULFONYL)AMINO]-2-(4-FLUOROPHENYL)-N-METHYL-5-(3-{[1-(PYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}PHENYL)-1-BENZOFURAN-3-CARBOXAMIDE
Descriptor:RNA-dependent RNA polymerase, 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, THIOCYANATE ION, ...
Authors:Sheriff, S.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ACS Med Chem Lett, 9, 2018
5QJ1
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-5-(3-{[1-(5-FLUOROPYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}-4-METHOXYPHENYL)-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE
Descriptor:RNA-dependent RNA polymerase, 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ACS Med Chem Lett, 9, 2018
5TWM
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
Descriptor:NS5B RNA-dependent RNA POLYMERASE, 5-[3-(tert-butylcarbamoyl)phenyl]-6-(ethylamino)-2-(4-fluorophenyl)-N-methylfuro[2,3-b]pyridine-3-carboxamide, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2016-11-14
Release date:2017-03-15
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017
5TWN
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA- DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-6-(ETHYLAMINO)-2-(4-FLUOROPHENYL)-N-METHYLFURO[2,3-B]PYRIDINE-3-CARBOXAMIDE
Descriptor:NS5B RNA- DEPENDENT RNA POLYMERASE, (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2016-11-14
Release date:2017-03-15
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm, 8, 2017
5WXG
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STRUCTURE OF TAF PHD FINGER DOMAIN BINDS TO H3(1-15)K4AC
Descriptor:Transcription initiation factor TFIID subunit 3, Histone H3K4ac, ZINC ION, ...
Authors:Zhao, S., Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WXH
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CRYSTAL STRUCTURE OF TAF3 PHD FINGER BOUND TO H3K4ME3
Descriptor:Transcription initiation factor TFIID subunit 3, Histone H3K4me3, ZINC ION
Authors:Zhao, S., Huang, J., Li, H.
Deposit date:2017-01-07
Release date:2017-08-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.297 Å)
Cite:Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6A4X
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OXIDASE CHAP-H2
Descriptor:Bleomycin resistance protein, FE (II) ION
Authors:Zhang, B., Wang, Y.S., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A4Z
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OXIDASE CHAP
Descriptor:ChaP protein, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A52
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OXIDASE CHAP-H1
Descriptor:dioxidase ChaP-H1, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A5F
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF NARGENICIN
Descriptor:NgnD
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019