Author results

6A4Z
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OXIDASE CHAP
Descriptor:ChaP protein, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A52
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OXIDASE CHAP-H1
Descriptor:dioxidase ChaP-H1, FE (II) ION
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-21
Release date:2018-08-29
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.
J. Am. Chem. Soc., 140, 2018
6A5F
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF NARGENICIN
Descriptor:NgnD
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
6A5G
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF STREPTOSEOMYCIN
Descriptor:[4+2] and [4+6] cyclase StmD
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
6A5H
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THE STRUCTURE OF [4+2] AND [6+4] CYCLASE IN THE BIOSYNTHETIC PATHWAY OF UNIDENTIFIED NATURAL PRODUCT
Descriptor:101015D
Authors:Zhang, B., Ge, H.M.
Deposit date:2018-06-23
Release date:2019-02-06
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.618 Å)
Cite:Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products.
Nature, 568, 2019
6BKB
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3A
Descriptor:Fab AR3A heavy chain, Polyprotein, Fab AR3A light chain, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.799 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKC
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3B
Descriptor:Fab AR3B heavy chain, Fab AR3B light chain, Polyprotein, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6BKD
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 CORE FROM GENOTYPE 6A BOUND TO BROADLY NEUTRALIZING ANTIBODY AR3D
Descriptor:Polyprotein, Fab AR3D heavy chain, Fab AR3D light chain, ...
Authors:Tzarum, N., Wilson, I.A., Law, M.
Deposit date:2017-11-08
Release date:2018-12-26
Last modified:2019-06-05
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.
Sci Adv, 5, 2019
6CE0
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CRYSTAL STRUCTURE OF A HIV-1 CLADE B TIER-3 ISOLATE H078.14 UFO-BG ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING FABS PGT124 AND 35O22 AT 4.6 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 Heavy chain, 35O22 Light chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-02-09
Release date:2018-12-05
Method:X-RAY DIFFRACTION (4.602 Å)
Cite:HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
2E0H
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SOLUTION STRUCTURE OF BMKALPHAIT01, AN ALPHA-INSECT TOXIN FROM THE VENOM OF THE CHINESE SCORPION BUTHUS MARTENSI KARSCH
Descriptor:Alpha-neurotoxin TX12
Authors:Tong, X.T., Chen, X., Wu, H.M.
Deposit date:2006-10-08
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of BmKalphaIT01, an alpha-Insect Toxin from the Venom of the Chinese Scorpion Buthus martensii Karsch
Biochemistry, 46, 2007
2FYZ
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STRUCTURAL OF MUMPS VIRUS FUSION PROTEIN CORE
Descriptor:Fusion glycoprotein F0
Authors:Lou, Z., Xu, Y., Liu, Y., Rao, Z.
Deposit date:2006-02-08
Release date:2007-04-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural characterization of mumps virus fusion protein core
Biochem.Biophys.Res.Commun., 348, 2006
3HHM
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CRYSTAL STRUCTURE OF P110ALPHA H1047R MUTANT IN COMPLEX WITH NISH2 OF P85ALPHA AND THE DRUG WORTMANNIN
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, niSH2 p85alpha, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
Authors:Amzel, L.M., Vogelstein, B., Gabelli, S.B., Mandelker, D.
Deposit date:2009-05-15
Release date:2009-09-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106, 2009
3HIZ
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CRYSTAL STRUCTURE OF P110ALPHA H1047R MUTANT IN COMPLEX WITH NISH2 OF P85ALPHA
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Amzel, L.M., Vogelstein, B., Gabelli, S.B., Mandelker, D.
Deposit date:2009-05-20
Release date:2009-09-29
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
Proc.Natl.Acad.Sci.USA, 106, 2009
3IEJ
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PYRAZOLE-BASED CATHEPSIN S INHIBITORS WITH ARYLALKYNES AS P1 BINDING ELEMENTS
Descriptor:Cathepsin S, 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol
Authors:Bembenek, S.
Deposit date:2009-07-22
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.
Bioorg.Med.Chem.Lett., 19, 2009
3LRS
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STRUCTURE OF PG16, AN ANTIBODY WITH BROAD AND POTENT NEUTRALIZATION OF HIV-1
Descriptor:PG-16 Heavy Chain Fab, PG-16 Light Chain Fab, N-ACETYL-D-GLUCOSAMINE
Authors:Pancera, M., Kwong, P.D.
Deposit date:2010-02-11
Release date:2010-06-09
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
J.Virol., 84, 2010
3PIQ
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CRYSTAL STRUCTURE OF HUMAN 2909 FAB, A QUATERNARY STRUCTURE-SPECIFIC ANTIBODY AGAINST HIV-1
Descriptor:Human monoclonal antibody 2909 Fab heavy chain, Human monoclonal antibody 2909 Fab light chain
Authors:Changela, A., Gorny, M.K., Zolla-Pazner, S., Kwong, P.D.
Deposit date:2010-11-07
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.325 Å)
Cite:Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1.
J.Virol., 85, 2011
3QW9
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CRYSTAL STRUCTURE OF BETAGLYCAN ZP-C DOMAIN
Descriptor:Transforming growth factor beta receptor type 3, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Lin, S.J., Jardetzky, T.S.
Deposit date:2011-02-27
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-{beta} binding.
Proc.Natl.Acad.Sci.USA, 108, 2011
3SE8
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC03 IN COMPLEX WITH HIV-1 GP120
Descriptor:HIV-1 Clade AE strain 93TH057 gp120, Heavy chain of antibody VRC03, Light chain of antibody VRC03, ...
Authors:Kwong, P.D., Zhou, T.
Deposit date:2011-06-10
Release date:2011-08-10
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (1.895 Å)
Cite:Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
Science, 333, 2011
3SE9
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CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC-PG04 IN COMPLEX WITH HIV-1 GP120
Descriptor:HIV-1 Clade AE strain 93TH057 gp120, Heavy chain of antibody VRC-PG04, Light chain of antibody VRC-PG04, ...
Authors:Kwong, P.D., Zhou, T.
Deposit date:2011-06-10
Release date:2011-08-10
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing.
Science, 333, 2011
4C50
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) D137S MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:CATALASE-PEROXIDASE, ALPHA-D-GLUCOSE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.), 49, 2013
4C51
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CRYSTAL STRUCTURE OF THE CATALASE-PEROXIDASE (KATG) R418L MUTANT FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:CATALASE-PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, ALPHA-D-GLUCOSE
Authors:Hersleth, H.-P., Zhao, X., Magliozzo, R.S., Andersson, K.K.
Deposit date:2013-09-10
Release date:2013-11-13
Last modified:2019-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Access Channel Residues Ser315 and Asp137 in Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) Control Peroxidatic Activation of the Pro-Drug Isoniazid.
Chem.Commun.(Camb.), 49, 2013
4I3R
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CRYSTAL STRUCTURE OF THE OUTER DOMAIN OF HIV-1 GP120 IN COMPLEX WITH VRC-PG04 SPACE GROUP P3221
Descriptor:Outer domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ...
Authors:Joyce, M.G., Biertumpfel, C., Nabel, G.J., Kwong, P.D.
Deposit date:2012-11-26
Release date:2013-01-09
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87, 2013
4I3S
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CRYSTAL STRUCTURE OF THE OUTER DOMAIN OF HIV-1 GP120 IN COMPLEX WITH VRC-PG04 SPACE GROUP P21
Descriptor:Outer domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ...
Authors:Joyce, M.G., Biertumpfel, C., Nabel, G.J., Kwong, P.D.
Deposit date:2012-11-26
Release date:2013-01-09
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87, 2013
4JAM
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTI-HIV-1 ANTIBODY CH103
Descriptor:ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, SULFATE ION, ...
Authors:Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013
4JAN
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY CH103 IN COMPLEX WITH HIV-1 GP120
Descriptor:ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ...
Authors:Zhou, T., Moquin, S., Zheng, A., Srivatsan, S., Kwong, P.D.
Deposit date:2013-02-18
Release date:2013-04-03
Last modified:2019-01-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Nature, 496, 2013