Author results

4OCT
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CRYSTAL STRUCTURE OF HUMAN ALKBH5 CRYSTALLIZED IN THE PRESENCE OF MN^{2+} AND 2-OXOGLUTARATE
分子名称:RNA demethylase ALKBH5, MANGANESE (II) ION, 2-OXOGLUTARIC ACID, ...
著者Tempel, W., Chao, X., Liu, K., Dong, A., Cerovina, T., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-01-09
公開日2014-04-16
最終更新日2014-12-24
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem., 289, 2014
4P7A
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CRYSTAL STRUCTURE OF HUMAN MLH1
分子名称:DNA mismatch repair protein Mlh1, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
著者Tempel, W., Lam, R., Zeng, H., Walker, J.R., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Wu, H., Structural Genomics Consortium (SGC)
登録日2014-03-26
公開日2014-04-09
最終更新日2015-12-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome.
Acta Crystallogr.,Sect.F, 71, 2015
4PXW
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CRYSTAL STRUCTURE OF HUMAN DCAF1 WD40 REPEATS (Q1250L)
分子名称:Protein VPRBP, UNKNOWN ATOM OR ION
著者Xu, C., Tempel, W., He, H., Li, Y., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-03-25
公開日2014-04-16
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Crystal structure of human DCAF1 WD40 repeats (Q1250L)
TO BE PUBLISHED
4QQ4
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CW-TYPE ZINC FINGER OF MORC3 IN COMPLEX WITH THE AMINO TERMINUS OF HISTONE H3
分子名称:MORC family CW-type zinc finger protein 3, Histone H3.3, ZINC ION, ...
著者Liu, Y., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-06-26
公開日2014-08-20
最終更新日2016-05-18
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins.
J.Biol.Chem., 291, 2016
4QQ6
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CRYSTAL STRUCTURE OF TUDOR DOMAIN OF SMN1 IN COMPLEX WITH A SMALL ORGANIC MOLECULE
分子名称:Survival motor neuron protein, UNKNOWN ATOM OR ION, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine
著者Liu, Y., Tempel, W., Iqbal, A., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Structural Genomics Consortium (SGC)
登録日2014-06-26
公開日2014-08-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule
To be Published
4QQD
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CRYSTAL STRUCTURE OF TANDEM TUDOR DOMAINS OF UHRF1 IN COMPLEX WITH A SMALL ORGANIC MOLECULE
分子名称:E3 ubiquitin-protein ligase UHRF1, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Iqbal, A., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Structural Genomics Consortium (SGC)
登録日2014-06-27
公開日2014-08-06
最終更新日2014-10-22
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal Structure of tandem tudor domains of UHRF1 in complex with a small organic molecule
To be Published
4QQG
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CRYSTAL STRUCTURE OF AN N-TERMINAL HTATIP FRAGMENT
分子名称:Histone acetyltransferase KAT5, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Wernimont, A.K., Dobrovetsky, E., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-06-27
公開日2014-07-09
最終更新日2018-05-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and histone binding studies of the chromo barrel domain of TIP60.
FEBS Lett., 592, 2018
4R3H
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THE CRYSTAL STRUCTURE OF AN APO RNA BINDING PROTEIN
分子名称:YTH domain-containing protein 1, UNKNOWN ATOM OR ION, SULFATE ION
著者Xu, C., Liu, K., Tempel, W., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-08-15
公開日2014-09-17
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Nat.Chem.Biol., 10, 2014
4R3I
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THE CRYSTAL STRUCTURE OF AN RNA COMPLEX
分子名称:YTH domain-containing protein 1, RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Liu, K., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-08-15
公開日2014-09-17
最終更新日2014-11-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain.
Nat.Chem.Biol., 10, 2014
4RCI
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CRYSTAL STRUCTURE OF YTHDF1 YTH DOMAIN
分子名称:YTH domain-containing family protein 1, UNKNOWN ATOM OR ION
著者Xu, C., Tempel, W., Liu, K., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-10-01
最終更新日2015-10-21
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4RCJ
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CRYSTAL STRUCTURE OF YTHDF1 YTH DOMAIN IN COMPLEX WITH 5MER M6A RNA
分子名称:YTH domain-containing family protein 1, RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-11-12
最終更新日2015-10-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4RCM
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CRYSTAL STRUCTURE OF THE PHO92 YTH DOMAIN IN COMPLEX WITH M6A
分子名称:Methylated RNA-binding protein 1, RNA (5'-R(*UP*G)-D(*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-09-16
公開日2014-11-19
最終更新日2015-10-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
J.Biol.Chem., 290, 2015
4ROF
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CRYSTAL STRUCTURE OF WW3 DOMAIN OF ITCH IN COMPLEX WITH TXNIP PEPTIDE
分子名称:E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-10-28
公開日2014-12-10
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Crystal Structure of WW3 domain of ITCH in complex with TXNIP peptide
To be Published
4ROJ
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CRYSTAL STRUCTURE OF THE VAV2 SH2 DOMAIN IN COMPLEX WITH TXNIP PHOSPHORYLATED PEPTIDE
分子名称:Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-10-28
公開日2014-12-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide
TO BE PUBLISHED
4RXJ
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CRYSTAL STRUCTURE OF WHSC1L1-PWWP2
分子名称:Histone-lysine N-methyltransferase NSD3, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Dong, A., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2014-12-11
公開日2015-01-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献crystal structure of WHSC1L1-PWWP2
To be Published
4YVD
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CRYTSAL STRUCTURE OF HUMAN PLEIOTROPIC REGULATOR 1 (PRL1)
分子名称:Pleiotropic regulator 1, SODIUM ION, CHLORIDE ION, ...
著者Dong, A., Zeng, H., Xu, C., Tempel, W., Li, Y., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Wu, H., Structural Genomics Consortium (SGC)
登録日2015-03-19
公開日2015-04-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
4Z0O
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CW-TYPE ZINC FINGER OF ZCWPW2 WITH F78D MUTATION
分子名称:Zinc finger CW-type PWWP domain protein 2, ZINC ION, SODIUM ION, ...
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-03-26
公開日2015-04-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献CW-type zinc finger of ZCWPW2 with F78D mutation
To be Published
4Z0R
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CRYSTAL STRUCTURE OF THE CW DOMAIN OF ZCWPW2 MUTANT F78R IN COMPLEX WITH HISTONE H3 PEPTIDE
分子名称:Zinc finger CW-type PWWP domain protein 2, Histone H3.1, ZINC ION, ...
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-03-26
公開日2015-04-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Crystal Structure of the CW domain of ZCWPW2 mutant F78R in complex with histone H3 peptide
To be Published
4Z3C
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ZINC FINGER REGION OF HUMAN TET3 IN COMPLEX WITH CPG DNA
分子名称:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase, UNKNOWN ATOM OR ION, ...
著者Liu, K., Xu, C., Tempel, W., Dong, A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-03-31
公開日2015-04-29
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
5C8H
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CRYSTAL STRUCTURE OF ORC2 C-TERMINAL DOMAIN
分子名称:Origin recognition complex subunit 2, UNKNOWN ATOM OR ION
著者Tempel, W., Xu, C., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-06-25
公開日2015-07-08
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Crystal structure of ORC2 C-terminal domain
To Be Published
5DWS
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CRYSTAL STRUCTURE OF ITCH WW3 DOMAIN IN COMPLEX WITH TXNIP PEPTIDE
分子名称:E3 ubiquitin-protein ligase Itchy homolog, txnip, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-09-22
公開日2015-10-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide
to be published
5DZD
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CRYSTAL STRUCTURE OF WW4 DOMAIN OF ITCH IN COMPLEX WITH TXNIP PEPTIDE
分子名称:E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-09-25
公開日2015-10-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
To be Published
5E1B
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CRYSTAL STRUCTURE OF NRMT1 IN COMPLEX WITH SPKRIA PEPTIDE
分子名称:N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
5E1D
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NTMT1 IN COMPLEX WITH YPKRIA PEPTIDE
分子名称:N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
5E1M
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CRYSTAL STRUCTURE OF NTMT1 IN COMPLEX WITH PPKRIA PEPTIDE
分子名称:N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, C., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015