Author results

2HVG
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CRYSTAL STRUCTURE OF ADENYLOSUCCINATE LYASE FROM PLASMODIUM VIVAX
Descriptor:Adenylosuccinate lyase, SULFATE ION
Authors:Wernimont, A.K., Dong, A., Lew, J., Wasney, G.A., Vedadi, M., Ren, H., Alam, Z., Qiu, W., Kozieradzki, I., Weigelt, J., Sundstrom, M., Edwards, A.M., Arrowsmith, C.H., Bochkarev, A., Hui, R., Hills, T., Structural Genomics Consortium (SGC)
Deposit date:2006-07-28
Release date:2006-08-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
2Z5D
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HUMAN UBIQUITIN-CONJUGATING ENZYME E2 H
Descriptor:Ubiquitin-conjugating enzyme E2 H, SODIUM ION
Authors:Bochkarev, A., Cui, H., Walker, J.R., Newman, E.M., Mackenzie, F., Battaile, K.P., Sundstrom, M., Arrowsmith, C., Edwards, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2007-07-06
Release date:2007-10-09
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
MOL.CELL PROTEOMICS, 11, 2012
4DVQ
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STRUCTURE OF HUMAN ALDOSTERONE SYNTHASE, CYP11B2, IN COMPLEX WITH DEOXYCORTICOSTERONE
Descriptor:Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Strushkevich, N., Shen, L., Tempel, W., Arrowsmith, C., Edwards, A., Usanov, S.A., Park, H.-W.
Deposit date:2012-02-23
Release date:2013-01-30
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Mol.Endocrinol., 27, 2013
4FDH
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STRUCTURE OF HUMAN ALDOSTERONE SYNTHASE, CYP11B2, IN COMPLEX WITH FADROZOLE
Descriptor:Cytochrome P450 11B2, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Strushkevich, N., Shen, L., Tempel, W., Arrowsmith, C., Edwards, A., Usanov, S.A., Park, H.-W.
Deposit date:2012-05-28
Release date:2013-01-30
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Mol.Endocrinol., 27, 2013
5WOF
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1.65 ANGSTROM STRUCTURE OF THE DYNEIN LIGHT CHAIN 1 FROM PLASMODIUM FALCIPARUM
Descriptor:Dynein light chain 1, putative
Authors:Walker, J.R., Lew, J., Amani, M., Alam, Z., Wasney, G., Boulanger, K., Sundstrom, M., Arrowsmith, C.H., Edwards, A.M., Hui, R., Botchkarev, A., Vedadi, M., Structural Genomics Consortium (SGC)
Deposit date:2017-08-02
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Genome-scale Protein Expression and Structural Biology of Plasmodium Falciparum and Related Apicomplexan Organisms.
MOL.BIOCHEM.PARASITOL., 151, 2007
2FCF
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THE CRYSTAL STRUCTURE OF THE 7TH PDZ DOMAIN OF MPDZ (MUPP-1)
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Berridge, G., Johansson, C., Colebrook, S., Salah, E., Burgess, N., Smee, C., Savitsky, P., Bray, J., Schoch, G., Phillips, C., Gileadi, C., Soundarajan, M., Yang, X., Elkins, J.M., Gorrec, F., Turnbull, A., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-12-12
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2FNE
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THE CRYSTAL STRUCTURE OF THE 13TH PDZ DOMAIN OF MPDZ
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Berridge, G., Johansson, C., Colebrook, S., Salah, E., Burgess, N., Smee, C., Savitsky, P., Bray, J., Schoch, G., Phillips, C., Gileadi, C., Soundarajan, M., Yang, X., Elkins, J.M., Gorrec, F., Turnbull, A., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-01-11
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2O2T
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THE CRYSTAL STRUCTURE OF THE 1ST PDZ DOMAIN OF MPDZ
Descriptor:Multiple PDZ domain protein
Authors:Papagrigoriou, E., Gileadi, C., Phillips, C., Johansson, C., Salah, E., Savitsky, P., Gorrec, F., Umeano, C., Berridge, G., Pike, A.C.W., Elkins, J., Edwards, A., Arrowsmith, C., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-11-30
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of the 1st PDZ domain of MPDZ
To be Published
4COO
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CRYSTAL STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE (DELTA516-525) AT 2.0 ANGSTROM RESOLUTION
Descriptor:CYSTATHIONINE BETA-SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, ACETATE ION, ...
Authors:McCorvie, T.J., Kopec, J., Vollamar, M., Strain-Damerell, C., Bushell, S., Bradley, A., Tallant, C., Kiyani, W., Froese, D.S., Carpenter, E.S., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-01-29
Release date:2014-03-05
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
4UUU
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1.7 A RESOLUTION STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE REGULATORY DOMAIN (DEL 516-525) IN COMPLEX WITH SAM
Descriptor:CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE, 1,2-ETHANEDIOL
Authors:Kopec, J., McCorvie, T.J., Fitzpatrick, F., Strain-Damerell, C., Froese, D.S., Tallant, C., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
2A72
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS7
Descriptor:Regulator of G-protein signalling 7, CHLORIDE ION
Authors:Schoch, G.A., Johansson, C., Phillips, C., Debreczeni, J., Smee, C., Elkins, J.M., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Gileadi, O., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-04
Release date:2005-07-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2AF0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS2
Descriptor:Regulator of G-protein signaling 2
Authors:Papagrigoriou, E., Johannson, C., Phillips, C., Smee, C., Elkins, J.M., Weigelt, J., Arrowsmith, C., Edwards, A., Sundstrom, M., Von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-25
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2BYG
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2ND PDZ DOMAIN OF DISCS LARGE HOMOLOGUE 2
Descriptor:CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110
Authors:Elkins, J.M., Schoch, G.A., Smee, C.E.A., Berridge, G., Salah, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-08-01
Release date:2005-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2ES0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS6
Descriptor:regulator of G-protein signalling 6
Authors:Schoch, G.A., Phillips, C., Turnbull, A., Niesen, F., Johansson, C., Elkins, J.M., Longman, E., Gilealdi, C., Sobott, F., Ball, L., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-10-25
Release date:2005-11-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2FLS
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CRYSTAL STRUCTURE OF HUMAN GLUTAREDOXIN 2 COMPLEXED WITH GLUTATHIONE
Descriptor:Glutaredoxin-2, GLUTATHIONE
Authors:Johansson, C., Smee, C., Kavanagh, K.L., Debreczeni, J., von Delft, F., Gileadi, O., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-01-06
Release date:2006-01-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of Human Glutaredoxin 2 complexed with glutathione
To be Published
2GZV
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THE CYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN PICK1
Descriptor:PRKCA-binding protein
Authors:Debreczeni, J.E., Elkins, J.M., Yang, X., Berridge, G., Bray, J., Colebrook, S., Smee, C., Savitsky, P., Gileadi, O., Turnbull, A., von Delft, F., Doyle, D.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
Deposit date:2006-05-12
Release date:2006-07-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2HE2
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CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN DISCS LARGE HOMOLOGUE 2, DLG2
Descriptor:Discs large homolog 2
Authors:Turnbull, A.P., Phillips, C., Berridge, G., Savitsky, P., Smee, C.E.A., Papagrigoriou, E., Debreczeni, J., Gorrec, F., Elkins, J.M., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2HE4
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THE CRYSTAL STRUCTURE OF THE SECOND PDZ DOMAIN OF HUMAN NHERF-2 (SLC9A3R2) INTERACTING WITH A MODE 1 PDZ BINDING MOTIF
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF2, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Elkins, J.M., Berridge, G., Gileady, O., Colebrook, S., Gileadi, C., Salah, E., Savitsky, P., Pantic, N., Gorrec, F., Bunkoczi, G., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2HT9
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THE STRUCTURE OF DIMERIC HUMAN GLUTAREDOXIN 2
Descriptor:Glutaredoxin-2, 12-mer peptide, GLUTATHIONE, ...
Authors:Johansson, C., Smee, C., Kavanagh, K.L., Debreczeni, J., von Delft, F., Gileadi, O., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-07-25
Release date:2006-08-29
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria
J.Biol.Chem., 282, 2007
2I1N
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CRYSTAL STRUCTURE OF THE 1ST PDZ DOMAIN OF HUMAN DLG3
Descriptor:Discs, large homolog 3, SODIUM ION
Authors:Turnbull, A.P., Phillips, C., Bunkoczi, G., Debreczeni, J., Ugochukwu, E., Pike, A.C.W., Gorrec, F., Umeano, C., Elkins, J., Berridge, G., Savitsky, P., Gileadi, O., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-08-14
Release date:2006-09-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions.
Protein Sci., 16, 2007
2IHD
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CRYSTAL STRUCTURE OF HUMAN REGULATOR OF G-PROTEIN SIGNALING 8, RGS8
Descriptor:Regulator of G-protein signaling 8, CHLORIDE ION
Authors:Turnbull, A.P., Papagrigoriou, E., Ugochukwu, E., Salah, E., Gileadi, C., Burgess, N., Bhatia, C., Gileadi, O., Bray, J., Elkins, J., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-09-26
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IWN
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3RD PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Gileadi, C., Savitsky, P., Berridge, G., Smee, C.E.A., Pike, A.C.W., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2IWO
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2012-10-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2IWP
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12TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ (CASP TARGET)
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Yang, X., Gileadi, C., Schoch, G., Johansson, C., Savitsky, P., Berridge, G., Smee, C.E.A., Turnbull, A., Pike, A., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extension.
Protein Sci., 16, 2007
2JM5
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2006-10-11
Release date:2006-10-24
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008