5DOX | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HYGROMYCIN-A AT 3.1A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-30 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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5DOY | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC HYGROMYCIN A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.6A RESOLUTION | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | | Authors: | Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N. | | Deposit date: | 2015-09-11 | | Release date: | 2015-12-30 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
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5HAU | | CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE BAC7(1-19) BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ... | | Authors: | Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A. | | Deposit date: | 2015-12-30 | | Release date: | 2016-04-06 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
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5HCP | | CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE METALNIKOWIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A. | | Deposit date: | 2016-01-04 | | Release date: | 2016-04-06 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (2.894 Å) | | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
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5HCQ | | CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN D15-19 BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A. | | Deposit date: | 2016-01-04 | | Release date: | 2016-04-06 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (2.801 Å) | | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
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5HCR | | CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN 10WT BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A. | | Deposit date: | 2016-01-04 | | Release date: | 2016-04-06 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
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5HD1 | | CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE PYRRHOCORICIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A. | | Deposit date: | 2016-01-04 | | Release date: | 2016-04-06 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
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5IPL | | SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B., Zuo, Y., Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5IPM | | SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B., Zuo, Y., Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5IPN | | SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B., Zuo, Y., Steitz, T.A. | | Deposit date: | 2016-03-09 | | Release date: | 2016-03-30 | | Last modified: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (4.61 Å) | | Cite: | Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5J4B | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S. | | Deposit date: | 2016-03-31 | | Release date: | 2016-04-27 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
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5J4C | | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION | | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | | Authors: | Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S. | | Deposit date: | 2016-03-31 | | Release date: | 2016-04-27 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
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5J8B | | CRYSTAL STRUCTURE OF ELONGATION FACTOR 4 (EF-4/LEPA) IN COMPLEX WITH GDPCP BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME | | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ... | | Authors: | Gagnon, M.G., Lin, J., Steitz, T.A. | | Deposit date: | 2016-04-07 | | Release date: | 2016-05-25 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Elongation factor 4 remodels the A-site tRNA on the ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5KTJ | | CRYSTAL STRUCTURE OF PISTOL, A CLASS OF SELF-CLEAVING RIBOZYME | | Descriptor: | Pistol (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*GP*UP*CP*CP*AP*A)-3'), SAMARIUM (III) ION, ... | | Authors: | Nguyen, L.A., Wang, J., Steitz, T.A. | | Deposit date: | 2016-07-11 | | Release date: | 2016-10-05 | | Last modified: | 2017-02-15 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Crystal structure of Pistol, a class of self-cleaving ribozyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TBZ | | E. COLI RNA POLYMERASE COMPLEXED WITH NUSG | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B., Steitz, T.A. | | Deposit date: | 2016-09-13 | | Release date: | 2016-12-07 | | Last modified: | 2017-09-20 | | Method: | X-RAY DIFFRACTION (7 Å) | | Cite: | Structural insights into NusG regulating transcription elongation.
Nucleic Acids Res., 45, 2017
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5VYC | | CRYSTAL STRUCTURE OF THE HUMAN 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH DENR-MCT-1. | | Descriptor: | 40S ribosomal protein S19, 40S ribosomal protein S20, 40S ribosomal protein S21, ... | | Authors: | Lomakin, I.B., Stolboushkina, E.A., Vaidya, A.T., Garber, M.B., Dmitriev, S.E., Steitz, T.A. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-19 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (6 Å) | | Cite: | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Cell Rep, 20, 2017
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5W2F | | CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN EIF2D AT 1.4 A RESOLUTION | | Descriptor: | Eukaryotic translation initiation factor 2D, FORMIC ACID | | Authors: | Vaidya, A.T., Lomakin, I.B., Joseph, N.N., Dmitriev, S.E., Steitz, T.A. | | Deposit date: | 2017-06-06 | | Release date: | 2017-08-02 | | Last modified: | 2017-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.
J. Mol. Biol., 429, 2017
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6B6H | | THE CRYO-EM STRUCTURE OF A BACTERIAL CLASS I TRANSCRIPTION ACTIVATION COMPLEX | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Liu, B., Hong, C., Huang, R., Yu, Z., Steitz, T.A. | | Deposit date: | 2017-10-02 | | Release date: | 2017-11-15 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of bacterial transcription activation.
Science, 358, 2017
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6C0J | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2 | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0K | | CRYSTAL STRUCTURE OF HIV-1 K103N MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2 | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (1.958 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0L | | CRYSTAL STRUCTURE OF HIV-1 E138K MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2 | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0N | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0O | | CRYSTAL STRUCTURE OF HIV-1 K103N MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0P | | CRYSTAL STRUCTURE OF HIV-1 E138K MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-01 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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6C0R | | CRYSTAL STRUCTURE OF HIV-1 K103N/Y181C MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A | | Descriptor: | Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ... | | Authors: | Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A. | | Deposit date: | 2018-01-02 | | Release date: | 2018-08-01 | | Method: | X-RAY DIFFRACTION (2.049 Å) | | Cite: | Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
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