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5DOX
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HYGROMYCIN-A AT 3.1A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-09-11
Release date:2015-12-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
5DOY
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC HYGROMYCIN A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ...
Authors:Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N.
Deposit date:2015-09-11
Release date:2015-12-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
5HAU
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE BAC7(1-19) BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2015-12-30
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCP
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE METALNIKOWIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCQ
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN D15-19 BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HCR
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE ONCOCIN 10WT BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5HD1
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CRYSTAL STRUCTURE OF ANTIMICROBIAL PEPTIDE PYRRHOCORICIN BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Gagnon, M.G., Roy, R.N., Lomakin, I.B., Florin, T., Mankin, A.S., Steitz, T.A.
Deposit date:2016-01-04
Release date:2016-04-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition.
Nucleic Acids Res., 44, 2016
5IPL
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SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Zuo, Y., Steitz, T.A.
Deposit date:2016-03-09
Release date:2016-03-30
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IPM
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SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Zuo, Y., Steitz, T.A.
Deposit date:2016-03-09
Release date:2016-03-30
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5IPN
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SIGMAS-TRANSCRIPTION INITIATION COMPLEX WITH 4-NT NASCENT RNA
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Zuo, Y., Steitz, T.A.
Deposit date:2016-03-09
Release date:2016-03-30
Last modified:2016-06-22
Method:X-RAY DIFFRACTION (4.61 Å)
Cite:Structures of E. coli sigma S-transcription initiation complexes provide new insights into polymerase mechanism.
Proc.Natl.Acad.Sci.USA, 113, 2016
5J4B
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J4C
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S.
Deposit date:2016-03-31
Release date:2016-04-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome.
Nucleic Acids Res., 44, 2016
5J8B
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CRYSTAL STRUCTURE OF ELONGATION FACTOR 4 (EF-4/LEPA) IN COMPLEX WITH GDPCP BOUND TO THE THERMUS THERMOPHILUS 70S RIBOSOME
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L1, ...
Authors:Gagnon, M.G., Lin, J., Steitz, T.A.
Deposit date:2016-04-07
Release date:2016-05-25
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Elongation factor 4 remodels the A-site tRNA on the ribosome.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KTJ
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CRYSTAL STRUCTURE OF PISTOL, A CLASS OF SELF-CLEAVING RIBOZYME
Descriptor:Pistol (50-MER), RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*GP*UP*CP*CP*AP*A)-3'), SAMARIUM (III) ION, ...
Authors:Nguyen, L.A., Wang, J., Steitz, T.A.
Deposit date:2016-07-11
Release date:2016-10-05
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Crystal structure of Pistol, a class of self-cleaving ribozyme.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5TBZ
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E. COLI RNA POLYMERASE COMPLEXED WITH NUSG
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Steitz, T.A.
Deposit date:2016-09-13
Release date:2016-12-07
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (7 Å)
Cite:Structural insights into NusG regulating transcription elongation.
Nucleic Acids Res., 45, 2017
5VYC
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CRYSTAL STRUCTURE OF THE HUMAN 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH DENR-MCT-1.
Descriptor:40S ribosomal protein S19, 40S ribosomal protein S20, 40S ribosomal protein S21, ...
Authors:Lomakin, I.B., Stolboushkina, E.A., Vaidya, A.T., Garber, M.B., Dmitriev, S.E., Steitz, T.A.
Deposit date:2017-05-24
Release date:2017-07-19
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (6 Å)
Cite:Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Cell Rep, 20, 2017
5W2F
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN EIF2D AT 1.4 A RESOLUTION
Descriptor:Eukaryotic translation initiation factor 2D, FORMIC ACID
Authors:Vaidya, A.T., Lomakin, I.B., Joseph, N.N., Dmitriev, S.E., Steitz, T.A.
Deposit date:2017-06-06
Release date:2017-08-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.
J. Mol. Biol., 429, 2017
6B6H
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THE CRYO-EM STRUCTURE OF A BACTERIAL CLASS I TRANSCRIPTION ACTIVATION COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Liu, B., Hong, C., Huang, R., Yu, Z., Steitz, T.A.
Deposit date:2017-10-02
Release date:2017-11-15
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of bacterial transcription activation.
Science, 358, 2017
6C0J
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0K
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CRYSTAL STRUCTURE OF HIV-1 K103N MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.958 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0L
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CRYSTAL STRUCTURE OF HIV-1 E138K MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR K-5A2
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-[(4-{[4-(4-cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl]amino}piperidin-1-yl)methyl]benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0N
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0O
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CRYSTAL STRUCTURE OF HIV-1 K103N MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0P
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CRYSTAL STRUCTURE OF HIV-1 E138K MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-01
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018
6C0R
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CRYSTAL STRUCTURE OF HIV-1 K103N/Y181C MUTANT REVERSE TRANSCRIPTASE IN COMPLEX WITH NON-NUCLEOSIDE INHIBITOR 25A
Descriptor:Reverse transcriptase/ribonuclease H, Reverse transcriptase p51 subunit, 4-({4-[(4-{4-[(E)-2-cyanoethenyl]-2,6-dimethylphenoxy}thieno[3,2-d]pyrimidin-2-yl)amino]piperidin-1-yl}methyl)benzene-1-sulfonamide, ...
Authors:Yang, Y., Nguyen, L.A., Smithline, Z.B., Steitz, T.A.
Deposit date:2018-01-02
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors.
Elife, 7, 2018