4UD5
| Structural Plasticity of Cid1 Provides a Basis for its RNA Terminal Uridylyl Transferase Activity | Descriptor: | POLY(A) RNA POLYMERASE PROTEIN CID1 | Authors: | Yates, L.A, Durrant, B.P, Fleurdepine, S, Harlos, K, Norbury, C.J, Gilbert, R.J.C. | Deposit date: | 2014-12-07 | Release date: | 2015-03-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structural Plasticity of Cid1 Provides a Basis for its Distributive RNA Terminal Uridylyl Transferase Activity. Nucleic Acids Res., 43, 2015
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6SB5
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8X7T
| MCM in the Apo state. | Descriptor: | mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | MCM in the Apo state To Be Published
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8X7U
| MCM in complex with dsDNA in presence of ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | MCM in complex with dsDNA in presence of ATP To Be Published
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1OEB
| Mona/Gads SH3C domain | Descriptor: | CADMIUM ION, GRB2-RELATED ADAPTOR PROTEIN 2, LYMPHOCYTE CYTOSOLIC PROTEIN 2 | Authors: | Harkiolaki, M, Lewitzky, M, Gilbert, R.J.C, Jones, E.Y, Bourette, R.P, Mouchiroud, G, Sondermann, H, Moarefi, I, Feller, S.M. | Deposit date: | 2003-03-24 | Release date: | 2003-04-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural Basis for SH3 Domain-Mediated High-Affinity Binding between Mona/Gads and Slp-76 Embo J., 22, 2003
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6SB1
| Crystal structure of murine perforin-2 P2 domain crystal form 1 | Descriptor: | CHLORIDE ION, GLYCEROL, Macrophage-expressed gene 1 protein | Authors: | Ni, T, Ginger, L, Gilbert, R.J.C. | Deposit date: | 2019-07-18 | Release date: | 2020-02-05 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Sci Adv, 6, 2020
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6SB3
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6SB4
| Crystal structure of murine perforin-2 P2 domain crystal form 2 | Descriptor: | Macrophage-expressed gene 1 protein | Authors: | Ni, T, Yu, X, Ginger, L, Gilbert, R.J.C. | Deposit date: | 2019-07-18 | Release date: | 2020-02-05 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity. Sci Adv, 6, 2020
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3OSK
| Crystal structure of human CTLA-4 apo homodimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, GLYCEROL | Authors: | Yu, C, Sonnen, A.F.-P, Ikemizu, S, Stuart, D.I, Gilbert, R.J.C, Davis, S.J. | Deposit date: | 2010-09-09 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering J.Biol.Chem., 286, 2011
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1YJD
| Crystal structure of human CD28 in complex with the Fab fragment of a mitogenic antibody (5.11A1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment of 5.11A1 antibody heavy chain, Fab fragment of 5.11A1 antibody light chain, ... | Authors: | Evans, E.J, Esnouf, R.M, Manso-Sancho, R, Gilbert, R.J.C, James, J.R, Sorensen, P, Stuart, D.I, Davis, S.J. | Deposit date: | 2005-01-14 | Release date: | 2005-02-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a soluble CD28-Fab complex Nat.Immunol., 6, 2005
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8OS2
| Structure of the human LYVE-1 (lymphatic vessel endothelial receptor-1) hyaluronan binding domain in an unliganded state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Lymphatic vessel endothelial hyaluronic acid receptor 1 | Authors: | Ni, T, Bannerji, S, Jackson, D.J, Gilbert, R.J.C. | Deposit date: | 2023-04-17 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A novel sliding interaction with hyaluronan underlies the mode of action of LYVE-1, the receptor for leucocyte entry and trafficking in the lymphatics To be published
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7PGN
| HHP-C in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGK
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2021-12-22 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | Descriptor: | Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGM
| HHIP-C in complex with heparin | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | Authors: | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | Deposit date: | 2021-08-14 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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2X44
| Structure of a strand-swapped dimeric form of CTLA-4 | Descriptor: | CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 | Authors: | Sonnen, A.F.-P, Yu, C, Evans, E.J, Stuart, D.I, Davis, S.J, Gilbert, R.J.C. | Deposit date: | 2010-01-28 | Release date: | 2010-04-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Domain Metastability: A Molecular Basis for Immunoglobulin Deposition? J.Mol.Biol., 399, 2010
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2WJX
| Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution | Descriptor: | GLUTAMATE RECEPTOR 2 | Authors: | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2009-06-01 | Release date: | 2009-08-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
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2WJW
| Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | Authors: | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2009-06-01 | Release date: | 2009-08-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
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5OUO
| Structure of TgPLP1 APCbeta domain | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5OUQ
| Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (5.11 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5OWN
| Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-09-01 | Release date: | 2018-04-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5OUP
| Structure of TgPLP1 MACPF domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Perforin-like protein 1 | Authors: | Ni, T, Gilbert, R.J.C. | Deposit date: | 2017-08-24 | Release date: | 2018-04-11 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structures of monomeric and oligomeric forms of theToxoplasma gondiiperforin-like protein 1. Sci Adv, 4, 2018
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5OPG
| Structure of the Hantaan virus Gn glycoprotein ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... | Authors: | Rissanen, I, Stass, R, Zeltina, A, Li, S, Hepojoki, J, Harlos, K, Gilbert, R.J.C, Huiskonen, J.T, Bowden, T.A. | Deposit date: | 2017-08-09 | Release date: | 2017-08-23 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope. J. Virol., 91, 2017
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2CL8
| Dectin-1 in complex with beta-glucan | Descriptor: | CALCIUM ION, CHLORIDE ION, DECTIN-1, ... | Authors: | Brown, J, O'Callaghan, C.A, Marshall, A.S.J, Gilbert, R.J.C, Siebold, C, Gordon, S, Brown, G.D, Jones, E.Y. | Deposit date: | 2006-04-26 | Release date: | 2007-05-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function. Protein Sci., 16, 2007
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2BK1
| The pore structure of pneumolysin, obtained by fitting the alpha carbon trace of perfringolysin O into a cryo-EM map | Descriptor: | PERFRINGOLYSIN O | Authors: | Tilley, S.J, Orlova, E.V, Gilbert, R.J.C, Andrew, P.W, Saibil, H.R. | Deposit date: | 2005-02-10 | Release date: | 2005-05-04 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (29 Å) | Cite: | Structural Basis of Pore Formation by the Bacterial Toxin Pneumolysin Cell(Cambridge,Mass.), 121, 2005
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