Author results

4GGV
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CRYSTAL STRUCTURE OF HMTT INVOLVED IN HIMASTATIN BIOSYNTHESIS
Descriptor:Cytochrome P450 superfamily protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhang, H., Chen, J., Wang, H., Zhang, H.
Deposit date:2012-08-07
Release date:2013-07-17
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis
Febs Lett., 587, 2013
5XEZ
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody, mAb1, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5XF1
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STRUCTURE OF THE FULL-LENGTH GLUCAGON CLASS B G PROTEIN-COUPLED RECEPTOR
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Antibody mAb1 Heavy chain, Antibody mAb1 Light chain, ...
Authors:Zhang, H., Qiao, A., Yang, D., Yang, L., Dai, A., de Graaf, C., Reedtz-Runge, S., Dharmarajan, V., Zhang, H., Han, G.W., Grant, T., Sierra, R., Weierstall, U., Nelson, G., Liu, W., Wu, Y., Ma, L., Cai, X., Lin, G., Wu, X., Geng, Z., Dong, Y., Song, G., Griffin, P., Lau, J., Cherezov, V., Yang, H., Hanson, M., Stevens, R., Jiang, H., Wang, M., Zhao, Q., Wu, B.
Deposit date:2017-04-06
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
5GRM
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CRYSTAL STRUCTURE OF RAT STING IN COMPLEX WITH CYCLIC GMP-AMP WITH 2'5'AND 3'5'PHOSPHODIESTER LINKAGE(2'3'-CGAMP)
Descriptor:Stimulator of interferon genes protein, cGAMP
Authors:Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D.
Deposit date:2016-08-11
Release date:2017-10-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
To Be Published
5GS5
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CRYSTAL STRUCTURE OF APO RAT STING
Descriptor:Stimulator of interferon genes protein, SULFATE ION
Authors:Zhang, H., Han, M.J., Tao, J.L., Ye, Z.Y., Du, X.X., Deng, M.J., Zhang, X.Y., Li, L.F., Jiang, Z.F., Su, X.D.
Deposit date:2016-08-13
Release date:2017-10-25
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Crystal structure of apo ratSTING
To Be Published
4MM0
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CRYSTAL STRUCTURE ANALYSIS OF THE PUTATIVE THIOETHER SYNTHASE SGVP INVOLVED IN THE TAILORING STEP OF GRISEOVIRIDIN
Descriptor:P450-like monooxygenase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Zhang, H., Huang, L., Yi, M., Cai, T., Zhang, H.
Deposit date:2013-09-07
Release date:2014-09-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin
To be Published
4PV5
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I IN COMPLEXED WITH 18-BETA-GLYCYRRHETINIC ACID
Descriptor:Lactoylglutathione lyase, ZINC ION, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID
Authors:Zhang, H., Zhai, J., Zhang, L.P., Zhao, Y.N., Li, C., Hu, X.P.
Deposit date:2014-03-15
Release date:2015-03-18
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor
Acta Pharmacol.Sin., 36, 2015
3OFS
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DYNAMIC CONFORMATIONS OF THE CD38-MEDIATED NAD CYCLIZATION CAPTURED USING MULTI-COPY CRYSTALLOGRAPHY
Descriptor:ADP-ribosyl cyclase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate
Authors:Zhang, H., Lee, H.C., Hao, Q.
Deposit date:2010-08-16
Release date:2010-12-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dynamic Conformations of the CD38-Mediated NAD Cyclization Captured in a Single Crystal
J.Mol.Biol., 405, 2011
4X2A
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CRYSTAL STRUCTURE OF MOUSE GLYOXALASE I COMPLEXED WITH BAICALEIN
Descriptor:Lactoylglutathione lyase, ZINC ION, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Authors:Zhang, H., Zhai, J., Zhang, L., Li, C., Zhao, Y., Hu, X.
Deposit date:2014-11-26
Release date:2015-09-16
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:In Vitro Inhibition of Glyoxalase by Flavonoids: New Insights from Crystallographic Analysis
Curr Top Med Chem, 16, 2016
4HFF
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CRYSTAL STRUCTURE OF THE TYPE VI EFFECTOR-IMMUNITY COMPLEX TAE4-TAI4 FROM SALMONELLA TYPHIMURIUM
Descriptor:Putative cytoplasmic protein, Putative periplasmic protein
Authors:Zhang, H., Gao, Z.Q., Dong, Y.H.
Deposit date:2012-10-05
Release date:2013-01-16
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein
J.Biol.Chem., 288, 2013
4HFK
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CRYSTAL STRUCTURE OF THE TYPE VI EFFECTOR-IMMUNITY COMPLEX TAE4-TAI4 FROM ENTEROBACTER CLOACAE
Descriptor:Putative cytoplasmic protein, Putative uncharacterized protein, SULFATE ION
Authors:Zhang, H., Gao, Z.Q., Dong, Y.H.
Deposit date:2012-10-05
Release date:2013-01-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.
J.Biol.Chem., 288, 2013
4HFL
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CRYSTAL STRUCTURE OF THE TYPE VI EFFECTOR TAE4 FROM ENTEROBACTER CLOACAE
Descriptor:Putative cytoplasmic protein
Authors:Zhang, H., Gao, Z.Q., Dong, Y.H.
Deposit date:2012-10-05
Release date:2013-01-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein.
J.Biol.Chem., 288, 2013
5ZGE
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CRYSTAL STRUCTURE OF NDM-1 AT PH5.5 (BIS-TRIS) IN COMPLEX WITH HYDROLYZED AMPICILLIN
Descriptor:Metallo-beta-lactamase type 2, (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ...
Authors:Zhang, H., Hao, Q.
Deposit date:2018-03-08
Release date:2018-08-22
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (1 Å)
Cite:Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.
Antimicrob. Agents Chemother., 62, 2018
1VQF
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GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 AND ILE 47 REPLACED BY VAL 47 (V35I, I47V)
Descriptor:GENE V PROTEIN
Authors:Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C.
Deposit date:1996-08-14
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
1VQI
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GENE V PROTEIN MUTANT WITH ILE 47 REPLACED BY VAL 47 (I47V)
Descriptor:GENE V PROTEIN
Authors:Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C.
Deposit date:1996-08-14
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
1VQJ
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GENE V PROTEIN MUTANT WITH VAL 35 REPLACED BY ILE 35 (V35I)
Descriptor:GENE V PROTEIN
Authors:Zhang, H., Skinner, M.M., Sandberg, W.S., Wang, A.H.-J., Terwilliger, T.C.
Deposit date:1996-08-14
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Context dependence of mutational effects in a protein: the crystal structures of the V35I, I47V and V35I/I47V gene V protein core mutants.
J.Mol.Biol., 259, 1996
3NSP
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD
Descriptor:Retinoid X receptor, alpha
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
3NSQ
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD COMPLEXED WITH ANTAGONIST DANTHRON
Descriptor:Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011
4PFX
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THE HIGHLY CONSERVED DOMAIN OF UNKNOWN FUNCTION 1792 HAS A DISTINCT GLYCOSYLTRANSFERASE FOLD
Descriptor:Putative glycosyltransferase (GalT1), URIDINE-5'-DIPHOSPHATE, ACETATE ION
Authors:Zhang, H., Wu, H.
Deposit date:2014-04-30
Release date:2014-07-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold.
Nat Commun, 5, 2014
4PHR
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DOMAIN OF UNKNOWN FUNCTION 1792 (DUF1792) WITH MANGANESE
Descriptor:Putative glycosyltransferase (GalT1), URIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Zhang, H., Wu, H.
Deposit date:2014-05-06
Release date:2014-08-06
Last modified:2015-10-14
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold.
Nat Commun, 5, 2014
4PHS
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SELENOMETHIONINE SUBSTITUTED STRUCTURE OF DOMAIN OF UNKNOWN FUNCTION 1792 (DUF1792)
Descriptor:Putative glycosyltransferase (GalT1), URIDINE-5'-DIPHOSPHATE
Authors:Zhang, H., Wu, H.
Deposit date:2014-05-06
Release date:2014-08-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold.
Nat Commun, 5, 2014
1GP7
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ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH
Descriptor:PHOSPHOLIPASE A2, CALCIUM ION
Authors:Zhang, H., Lin, Z.
Deposit date:2001-10-30
Release date:2002-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a Cardiotoxic Phospholipase A(2) from Ophiophagus Hannah with the "Pancreatic Loop"
J.Struct.Biol., 138, 2002
1HS1
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SOLUTION STRUCTURE OF RNA HAIRPIN LOOP UUAACU AS PART OF HAIRPIN R(GCGUUAACUCGCA)
Descriptor:5'-R(*GP*CP*GP*UP*UP*AP*AP*CP*UP*CP*GP*CP*A)-3'
Authors:Zhang, H., Culyba, M., Volkman, H., Krugh, T.R.
Deposit date:2000-12-22
Release date:2003-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Characterization of Six-Nucleotide RNA Hairpin loops: r(UUAAUU), r(UUAAAU), r(UUAACU)
To be Published
1HS3
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SOLUTION STRUCTURE OF RNA HAIRPIN LOOP UUAAUU AS PART OF HAIRPIN R(GCGUUAAUUCGCA)
Descriptor:5'-R(*GP*CP*GP*UP*UP*AP*AP*UP*UP*CP*GP*CP*A)-3'
Authors:Zhang, H., Culyba, M., Volkman, H., Krugh, T.R.
Deposit date:2000-12-22
Release date:2003-09-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Characterization of Six-Nucleotide RNA Hairpin loops: r(UUAAUU), r(UUAAAU), r(UUAACU)
To be Published