6PCV
| Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 | 著者 | Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G. | 登録日 | 2019-06-18 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold. Sci Adv, 5, 2019
|
|
7SYF
| Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1) | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Endolysin chimera | 著者 | Lupton, C.J, Bayly-Jones, C, Ellisdon, A.M. | 登録日 | 2021-11-24 | 公開日 | 2022-07-27 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism. Nat.Struct.Mol.Biol., 29, 2022
|
|
7CSP
| Structure of Ephexin4 IDPSH | 分子名称: | Rho guanine nucleotide exchange factor 16 | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | 登録日 | 2020-08-15 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7CSR
| Structure of Ephexin4 R676L | 分子名称: | Rho guanine nucleotide exchange factor 16 | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | 登録日 | 2020-08-17 | 公開日 | 2021-02-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7CSO
| Structure of Ephexin4 DH-PH-SH3 | 分子名称: | Rho guanine nucleotide exchange factor 16, SULFATE ION | 著者 | Zhang, M, Lin, L, Wang, C, Zhu, J. | 登録日 | 2020-08-15 | 公開日 | 2021-02-24 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
3JZY
| Crystal structure of human Intersectin 2 C2 domain | 分子名称: | Intersectin 2, UNKNOWN ATOM OR ION | 著者 | Shen, Y, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2009-09-24 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Crystal structure of human Intersectin 2 C2 domain To be Published
|
|
2PZ1
| |
3T06
| |
4GZU
| |
4GOU
| Crystal structure of an RGS-RhoGEF from Entamoeba histolytica | 分子名称: | EhRGS-RhoGEF | 著者 | Bosch, D.E, Kimple, A.J, Muller, R.E, Willard, F.S, Machius, M, Siderovski, D.P. | 登録日 | 2012-08-20 | 公開日 | 2013-01-09 | 最終更新日 | 2013-01-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis. Structure, 21, 2013
|
|
1XDV
| Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | 分子名称: | Son of sevenless protein homolog 1 | 著者 | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | 登録日 | 2004-09-08 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
|
|
1X86
| |
1XCG
| Crystal Structure of Human RhoA in complex with DH/PH fragment of PDZRHOGEF | 分子名称: | Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | 著者 | Derewenda, U, Oleksy, A, Stevenson, A.S, Korczynska, J, Dauter, Z, Somlyo, A.P, Otlewski, J, Somlyo, A.V, Derewenda, Z.S. | 登録日 | 2004-09-01 | 公開日 | 2004-12-14 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle Structure, 12, 2004
|
|
1XD4
| Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS) | 分子名称: | Son of sevenless protein homolog 1 | 著者 | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | 登録日 | 2004-09-03 | 公開日 | 2004-11-02 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | 主引用文献 | Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
|
|
3MPX
| Crystal structure of the DH and PH-1 domains of human FGD5 | 分子名称: | FYVE, RhoGEF and PH domain-containing protein 5, UNKNOWN ATOM OR ION | 著者 | Shen, Y, Nedyalkova, L, Tong, Y, Tempel, W, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2010-04-27 | 公開日 | 2010-06-23 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the DH and PH-1 domains of human FGD5 TO BE PUBLISHED
|
|
1KI1
| Guanine Nucleotide Exchange Region of Intersectin in Complex with Cdc42 | 分子名称: | G25K GTP-binding protein, placental isoform, SULFATE ION, ... | 著者 | Snyder, J.T, Pruitt, W.M, Der, C.J, Sondek, J. | 登録日 | 2001-12-02 | 公開日 | 2002-05-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
|
|
4H6Y
| |
1KZ7
| Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 | 分子名称: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | 著者 | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | 登録日 | 2002-02-06 | 公開日 | 2002-03-20 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
|
|
1KZG
| DbsCdc42(Y889F) | 分子名称: | CDC42 HOMOLOG, GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS | 著者 | Rossman, K.L, Worthylake, D.K, Snyder, J.T, Siderovski, D.P, Campbell, S.L, Sondek, J. | 登録日 | 2002-02-06 | 公開日 | 2002-03-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J., 21, 2002
|
|
1LB1
| Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA | 分子名称: | Guanine nucleotide exchange factor DBS, Transforming protein RhoA | 著者 | Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. | 登録日 | 2002-04-01 | 公開日 | 2002-05-29 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
|
|
5JHH
| Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11 | 分子名称: | 3-{3-[ethyl(quinolin-2-yl)amino]phenyl}propanoic acid, GLYCEROL, Rho guanine nucleotide exchange factor 11, ... | 著者 | Lv, Z, Wang, R, Ma, L, Miao, Q, Wu, J, Yan, Z, Li, J, Miao, L, Wang, F. | 登録日 | 2016-04-21 | 公開日 | 2017-04-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and PDZRhoGEF To Be Published
|
|
5JHG
| Crystal structure of the complex between the human RhoA and the DH/PH domain of human ARHGEF11 | 分子名称: | GLYCEROL, Rho guanine nucleotide exchange factor 11, Transforming protein RhoA | 著者 | Wang, R, Chen, Q, Zhang, H, Yan, Z, Li, J, Miao, L, Wang, F. | 登録日 | 2016-04-21 | 公開日 | 2017-04-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA bound with its inhibitor and ARHGEF11 To Be Published
|
|
5O33
| A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 | 分子名称: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Kalirin, ... | 著者 | Gray, J, Krojer, T, Talon, R, Fairhead, M, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P, von Delft, F. | 登録日 | 2017-05-23 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 To Be Published
|
|
5QQN
| PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-010-382-606 | 分子名称: | 1,2-ETHANEDIOL, Kalirin, N-cyclopropyl-2-(4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}-1H-pyrazol-1-yl)acetamide, ... | 著者 | Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. | 登録日 | 2019-05-03 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | PanDDA analysis group deposition To Be Published
|
|
5QQK
| PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-359-835 | 分子名称: | 1,2-ETHANEDIOL, Kalirin, N-{1-[2-(diethylamino)ethyl]-1H-indol-5-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea, ... | 著者 | Gray, J.L, Krojer, T, Talon, R, Douangamath, A, Jimenez Antunez, C, Bountra, C, Arrowsmith, C.H, Edwards, A, Brennan, P.E, von Delft, F. | 登録日 | 2019-05-03 | 公開日 | 2019-12-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | PanDDA analysis group deposition To Be Published
|
|