6PUR
| Human TRPM2 bound to ADPR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, Transient receptor potential cation channel subfamily M member 2 | 著者 | Du, J, Lu, W, Huang, Y. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PW4
| Cryo-EM Structure of Thermo-Sensitive TRP Channel TRP1 from the Alga Chlamydomonas reinhardtii in Detergent | 分子名称: | (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | McGoldrick, L.L, Singh, A.K, Sobolevsky, A.I. | 登録日 | 2019-07-22 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii. Nat Commun, 10, 2019
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6PUU
| Human TRPM2 bound to 8-Br-cADPR and calcium | 分子名称: | (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | 著者 | Du, J, Lu, W, Huang, Y. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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6PUO
| Human TRPM2 in the apo state | 分子名称: | Transient receptor potential cation channel subfamily M member 2 | 著者 | Du, J, Lu, W, Huang, Y. | 登録日 | 2019-07-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. Elife, 8, 2019
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5WO7
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5WO6
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7CR2
| human KCNQ2 in complex with retigabine | 分子名称: | Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR7
| human KCNQ2-CaM in complex with retigabine | 分子名称: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR0
| human KCNQ2 in apo state | 分子名称: | Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR3
| human KCNQ2-CaM in apo state | 分子名称: | Calmodulin-3, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR4
| human KCNQ2-CaM in complex with ztz240 | 分子名称: | Calmodulin-3, N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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7CR1
| human KCNQ2 in complex with ztz240 | 分子名称: | N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | 著者 | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | 登録日 | 2020-08-12 | 公開日 | 2020-09-16 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res., 31, 2021
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5XSY
| Structure of the Nav1.4-beta1 complex from electric eel | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | 著者 | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | 登録日 | 2017-06-15 | 公開日 | 2017-08-09 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of the Nav1.4-beta 1 Complex from Electric Eel. Cell, 170, 2017
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7D2K
| Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a | 分子名称: | 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 | 著者 | Singh, A.K, Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2020-09-16 | 公開日 | 2021-10-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.698 Å) | 主引用文献 | Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
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7DTC
| voltage-gated sodium channel Nav1.5-E1784K | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Pan, X, Li, Z. | 登録日 | 2021-01-04 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7DTD
| Voltage-gated sodium channel Nav1.1 and beta4 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 1 subunit alpha, ... | 著者 | Yan, N, Pan, X, Li, Z, Huang, G. | 登録日 | 2021-01-04 | 公開日 | 2021-04-07 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies. Proc.Natl.Acad.Sci.USA, 118, 2021
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6LQA
| voltage-gated sodium channel Nav1.5 with quinidine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Li, Z, Pan, X, Huang, G. | 登録日 | 2020-01-13 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Angew.Chem.Int.Ed.Engl., 60, 2021
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7EEB
| Structure of the CatSpermasome | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, J.P, Ke, M. | 登録日 | 2021-03-18 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure of a mammalian sperm cation channel complex. Nature, 595, 2021
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7E87
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7E84
| CryoEM structure of human Kv4.2-KChIP1 complex | 分子名称: | Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | 著者 | Kise, Y, Nureki, O. | 登録日 | 2021-02-28 | 公開日 | 2021-10-13 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7E83
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7E8E
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6MU2
| Structure of full-length IP3R1 channel in the Apo-state | 分子名称: | Inositol 1,4,5-trisphosphate receptor type 1 | 著者 | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | 登録日 | 2018-10-22 | 公開日 | 2018-12-05 | 最終更新日 | 2019-11-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
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6MJ2
| Human TRPM2 ion channel in a calcium- and ADPR-bound state | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2018-09-20 | 公開日 | 2018-12-12 | 最終更新日 | 2019-01-02 | 実験手法 | ELECTRON MICROSCOPY (6.36 Å) | 主引用文献 | Structures and gating mechanism of human TRPM2. Science, 362, 2018
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6MIX
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