6LQA

voltage-gated sodium channel Nav1.5 with quinidine

Summary for 6LQA

• Entry DOI: 10.2210/pdb6lqa/pdb
• EMDB information: 0942
• Descriptor: Sodium channel protein type 5 subunit alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine (3 entities in total)
• Functional Keywords: membrane protein, voltage-gated sodium channel, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 234059.23

Authors

Yan, N.,Li, Z.,Pan, X.,Huang, G. (deposition date: 2020-01-13, release date: 2021-03-24, Last modification date: 2021-05-19)

• Primary citation: Li, Z.,Jin, X.,Wu, T.,Huang, G.,Wu, K.,Lei, J.,Pan, X.,Yan, N.; Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*.; Angew.Chem.Int.Ed.Engl., 60:11474-11480, 2021; PubMed: 33684260; DOI: 10.1002/anie.202102196

Experimental method

ELECTRON MICROSCOPY (3.3 Å)