6LQA
voltage-gated sodium channel Nav1.5 with quinidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0002027 | biological_process | regulation of heart rate |
| B | 0003161 | biological_process | cardiac conduction system development |
| B | 0003231 | biological_process | cardiac ventricle development |
| B | 0003360 | biological_process | brainstem development |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005248 | molecular_function | voltage-gated sodium channel activity |
| B | 0005261 | molecular_function | monoatomic cation channel activity |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005516 | molecular_function | calmodulin binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005730 | cellular_component | nucleolus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005901 | cellular_component | caveola |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0009986 | cellular_component | cell surface |
| B | 0010765 | biological_process | positive regulation of sodium ion transport |
| B | 0014704 | cellular_component | intercalated disc |
| B | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| B | 0016020 | cellular_component | membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0017134 | molecular_function | fibroblast growth factor binding |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0019904 | molecular_function | protein domain specific binding |
| B | 0021537 | biological_process | telencephalon development |
| B | 0021549 | biological_process | cerebellum development |
| B | 0030018 | cellular_component | Z disc |
| B | 0030315 | cellular_component | T-tubule |
| B | 0030506 | molecular_function | ankyrin binding |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0042475 | biological_process | odontogenesis of dentin-containing tooth |
| B | 0044325 | molecular_function | transmembrane transporter binding |
| B | 0045760 | biological_process | positive regulation of action potential |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050679 | biological_process | positive regulation of epithelial cell proliferation |
| B | 0050998 | molecular_function | nitric-oxide synthase binding |
| B | 0051899 | biological_process | membrane depolarization |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060048 | biological_process | cardiac muscle contraction |
| B | 0060307 | biological_process | regulation of ventricular cardiac muscle cell membrane repolarization |
| B | 0060371 | biological_process | regulation of atrial cardiac muscle cell membrane depolarization |
| B | 0060372 | biological_process | regulation of atrial cardiac muscle cell membrane repolarization |
| B | 0060373 | biological_process | regulation of ventricular cardiac muscle cell membrane depolarization |
| B | 0070161 | cellular_component | anchoring junction |
| B | 0071277 | biological_process | cellular response to calcium ion |
| B | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| B | 0086004 | biological_process | regulation of cardiac muscle cell contraction |
| B | 0086005 | biological_process | ventricular cardiac muscle cell action potential |
| B | 0086006 | molecular_function | voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
| B | 0086010 | biological_process | membrane depolarization during action potential |
| B | 0086012 | biological_process | membrane depolarization during cardiac muscle cell action potential |
| B | 0086014 | biological_process | atrial cardiac muscle cell action potential |
| B | 0086015 | biological_process | SA node cell action potential |
| B | 0086016 | biological_process | AV node cell action potential |
| B | 0086043 | biological_process | bundle of His cell action potential |
| B | 0086045 | biological_process | membrane depolarization during AV node cell action potential |
| B | 0086046 | biological_process | membrane depolarization during SA node cell action potential |
| B | 0086047 | biological_process | membrane depolarization during Purkinje myocyte cell action potential |
| B | 0086048 | biological_process | membrane depolarization during bundle of His cell action potential |
| B | 0086060 | molecular_function | voltage-gated sodium channel activity involved in AV node cell action potential |
| B | 0086061 | molecular_function | voltage-gated sodium channel activity involved in bundle of His cell action potential |
| B | 0086062 | molecular_function | voltage-gated sodium channel activity involved in Purkinje myocyte action potential |
| B | 0086063 | molecular_function | voltage-gated sodium channel activity involved in SA node cell action potential |
| B | 0086067 | biological_process | AV node cell to bundle of His cell communication |
| B | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| B | 0097110 | molecular_function | scaffold protein binding |
| B | 0098912 | biological_process | membrane depolarization during atrial cardiac muscle cell action potential |
| B | 1902305 | biological_process | regulation of sodium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1126 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-SER131 | |
| B | ARG179-PRO192 | |
| B | SER234-ASP252 | |
| B | VAL411-PRO717 | |
| B | ILE768-TRP781 | |
| B | TRP822-GLY837 | |
| B | LEU939-TRP1206 | |
| B | LYS1257-ALA1270 | |
| B | PHE1317-SER1333 | |
| B | GLY1467-ALA1529 | |
| B | LYS1578-ASN1589 | |
| B | ARG1638-ALA1656 | |
| B | LEU1772-VAL2016 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LEU132-GLN150 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 307 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | HIS151-THR157 | |
| B | ASP211-SER216 | |
| B | MET273-SER357 | |
| B | ARG383-TYR389 | |
| B | GLU737-GLU747 | |
| B | SER802-ASN803 | |
| B | GLY857-ASP883 | |
| B | ASP905-LEU917 | |
| B | GLU1225-VAL1237 | |
| B | THR1290-GLY1297 | |
| B | ASN1354-VAL1405 | |
| B | ALA1428-LEU1444 | |
| B | GLU1548-ASN1558 | |
| B | LEU1608-THR1620 | |
| B | GLY1675-THR1696 | |
| B | ILE1720-GLY1748 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LYS158-ALA178 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | TRP193-VAL210 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ALA217-ILE233 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | VAL253-PHE272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | PHE358-LEU382 | |
| B | PHE884-TRP904 | |
| B | GLY1406-ALA1427 | |
| B | PHE1697-PRO1719 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | MET390-ALA410 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | PHE718-LEU736 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | MET748-LYS767 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ASN782-MET801 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LEU804-SER821 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ALA838-VAL856 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | VAL918-LEU938 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | PHE1207-PHE1224 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LEU1238-LEU1256 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | TRP1271-ASN1289 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | PRO1298-ARG1316 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ILE1334-VAL1353 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | TYR1445-ILE1466 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | PHE1530-VAL1547 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ILE1559-VAL1577 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | SER1590-VAL1607 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LEU1621-ILE1637 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | LEU1657-PHE1674 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| B | ILE1749-ILE1771 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23092124 |
| Chain | Residue | Details |
| B | SER36 | |
| B | SER457 | |
| B | SER460 | |
| B | SER483 | |
| B | SER484 | |
| B | SER497 | |
| B | SER510 | |
| B | SER571 | |
| B | SER664 | |
| B | SER667 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23092124 |
| Chain | Residue | Details |
| B | THR38 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P15389 |
| Chain | Residue | Details |
| B | THR486 |
| site_id | SWS_FT_FI31 |
| Number of Residues | 3 |
| Details | MOD_RES: Omega-N-methylarginine; alternate => ECO:0000269|PubMed:21726068 |
| Chain | Residue | Details |
| B | ARG526 | |
| B | ARG680 | |
| B | ARG513 |
| site_id | SWS_FT_FI32 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJV9 |
| Chain | Residue | Details |
| B | SER539 |
| site_id | SWS_FT_FI33 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:19666841 |
| Chain | Residue | Details |
| B | SER1503 |
| site_id | SWS_FT_FI34 |
| Number of Residues | 14 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | ASN214 | |
| B | ASN283 | |
| B | ASN288 | |
| B | ASN291 | |
| B | ASN318 | |
| B | ASN328 | |
| B | ASN740 | |
| B | ASN803 | |
| B | ASN864 | |
| B | ASN1365 | |
| B | ASN1374 | |
| B | ASN1380 | |
| B | ASN1388 | |
| B | ASN1736 |
