6PUU

Human TRPM2 bound to 8-Br-cADPR and calcium

Summary for 6PUU

• Entry DOI: 10.2210/pdb6puu/pdb
• EMDB information: 20478 20479 20480 20482
• Descriptor: Transient receptor potential cation channel subfamily M member 2, (2R,3R,4S,5R,13R,14S,15R,16R)-24-amino-18-bromo-3,4,14,15-tetrahydroxy-7,9,11,25,26-pentaoxa-17,19,22-triaza-1-azonia-8 ,10-diphosphapentacyclo[18.3.1.1^2,5^.1^13,16^.0^17,21^]hexacosa-1(24),18,20,22-tetraene-8,10-diolate 8,10-dioxide, CALCIUM ION (3 entities in total)
• Functional Keywords: trpm2 channel, 8-br-cadpr, calcium, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 691765.38

Authors

Du, J.,Lu, W.,Huang, Y. (deposition date: 2019-07-18, release date: 2019-09-25, Last modification date: 2024-03-20)

• Primary citation: Huang, Y.,Roth, B.,Lu, W.,Du, J.; Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.; Elife, 8:-, 2019; PubMed: 31513012; DOI: 10.7554/eLife.50175

Experimental method

ELECTRON MICROSCOPY (3.7 Å)