PDB: 2396 件ウェブページステータス検索Chemie searchBIRD

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6C23	Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ... 著者 Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E. 登録日 2018-01-05 公開日 2018-01-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359, 2018
6C24	Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ... 著者 Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E. 登録日 2018-01-06 公開日 2018-01-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359, 2018
6BW3	Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide 分子名称: Histone-binding protein RBBP4, MDS1 and EVI1 complex locus protein MDS1, UNKNOWN ATOM OR ION 著者 Ivanochko, D, Halabelian, L, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2017-12-14 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Res., 47, 2019
3IKO	Crystal structure of the heterotrimeric Sec13-Nup145C-Nup84 nucleoporin complex 分子名称: Nucleoporin NUP145C, Nucleoporin NUP84, Protein transport protein SEC13 著者 Nagy, V, Hsia, K.-C, Debler, E.W, Davenport, A, Blobel, G, Hoelz, A. 登録日 2009-08-06 公開日 2009-10-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of a trimeric nucleoporin complex reveals alternate oligomerization states. Proc.Natl.Acad.Sci.USA, 106, 2009
3JRO	NUP84-NUP145C-SEC13 edge element of the NPC lattice 分子名称: Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84 著者 Brohawn, S.G, Schwartz, T.U. 登録日 2009-09-08 公開日 2009-10-27 最終更新日 2017-08-02 実験手法 X-RAY DIFFRACTION (4.004 Å) 主引用文献 Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009
3MMY	Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclear pore complex protein Nup98, mRNA export factor 著者 Hoelz, A, Ren, Y. 登録日 2010-04-20 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc.Natl.Acad.Sci.USA, 107, 2010
3MKS	Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 分子名称: 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ... 著者 Orlicky, S, Sicheri, F, Tyers, M, Tang, X. 登録日 2010-04-15 公開日 2010-07-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28, 2010
3MKQ	Crystal structure of yeast alpha/betaprime-COP subcomplex of the COPI vesicular coat 分子名称: Coatomer beta'-subunit, Coatomer subunit alpha 著者 Lee, C, Goldberg, J. 登録日 2010-04-15 公開日 2010-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats. Cell(Cambridge,Mass.), 142, 2010
3MZK	Sec13/Sec16 complex, S.cerevisiae 分子名称: Protein transport protein SEC13, Protein transport protein SEC16 著者 Whittle, J.R, Schwartz, T.U. 登録日 2010-05-12 公開日 2010-08-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J.Cell Biol., 190, 2010
3MZL	Sec13/Sec31 edge element, loop deletion mutant 分子名称: Protein transport protein SEC13, Protein transport protein SEC31 著者 Whittle, J.R, Schwartz, T.U. 登録日 2010-05-12 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat. J.Cell Biol., 190, 2010
5EMM	Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EML	Crystal structure of PRMT5:MEP50 with Compound 10 and SAM 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EMK	Crystal structure of PRMT5:MEP50 with Compound 9 and sinefungin 分子名称: GLYCEROL, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5EMJ	Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin 分子名称: (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol, GLYCEROL, Methylosome protein 50, ... 著者 Boriack-Sjodin, P.A, Jin, L. 登録日 2015-11-06 公開日 2016-02-24 最終更新日 2018-04-18 実験手法 X-RAY DIFFRACTION (2.273 Å) 主引用文献 Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med Chem Lett, 7, 2016
5FA5	Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Histone H4, Methylosome protein 50, ... 著者 Sprague, E.R, McNamara, J.T. 登録日 2015-12-10 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351, 2016
5FLC	Architecture of human mTOR Complex 1 - 5.9 Angstrom reconstruction 分子名称: FKBP, RAPAMYCIN IMMUNOSUPPRESSANT DRUG, REGULATORY-ASSOCIATED PROTEIN OF MTOR, ... 著者 Aylett, C.H.S, Sauer, E, Imseng, S, Boehringer, D, Hall, M.N, Ban, N, Maier, T. 登録日 2015-10-23 公開日 2015-12-30 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Architecture of Human Mtor Complex 1 Science, 351, 2016
5G04	Structure of the human APC-Cdc20-Hsl1 complex 分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... 著者 Zhang, S, Chang, L, Alfieri, C, Zhang, Z, Yang, J, Maslen, S, Skehel, M, Barford, D. 登録日 2016-03-16 公開日 2016-05-25 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular Mechanism of Apc/C Activation by Mitotic Phosphorylation. Nature, 533, 2016
5FXY	Structure of the human RBBP4:MTA1(464-546) complex 分子名称: HISTONE-BINDING PROTEIN RBBP4, METASTASIS-ASSOCIATED PROTEIN MTA1 著者 Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R. 登録日 2016-03-03 公開日 2016-05-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife, 5, 2016
5TEF	Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, Gem-associated protein 5, ... 著者 Chao, X, Tempel, W, Bian, C, He, H, Cerovina, T, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-09-21 公開日 2016-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev., 30, 2016
5H14	EED in complex with an allosteric PRC2 inhibitor EED666 分子名称: 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ... 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-10-08 公開日 2017-01-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017
5H1L	Crystal structure of WD40 repeat domains of Gemin5 in complex with 7-nt U4 snRNA fragment 分子名称: GLYCEROL, Gem-associated protein 5, U4 snRNA (5'-R(*AP*UP*UP*UP*UP*UP*G)-3') 著者 Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M. 登録日 2016-10-10 公開日 2016-11-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5 Genes Dev., 30, 2016
5H25	EED in complex with PRC2 allosteric inhibitor compound 11 分子名称: 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-10-14 公開日 2017-01-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem., 60, 2017
5H15	EED in complex with PRC2 allosteric inhibitor EED709 分子名称: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-10-08 公開日 2017-01-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017
5H1M	Crystal structure of WD40 repeat domains of Gemin5 in complex with M7G 分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Gem-associated protein 5 著者 Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M. 登録日 2016-10-10 公開日 2016-11-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.492 Å) 主引用文献 Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5 Genes Dev., 30, 2016
5H19	EED in complex with PRC2 allosteric inhibitor EED162 分子名称: 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED 著者 Zhao, K, Zhao, M, Luo, X, Zhang, H. 登録日 2016-10-08 公開日 2017-01-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017

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