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5FA5

Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide

Summary for 5FA5
Entry DOI10.2210/pdb5fa5/pdb
DescriptorProtein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4, ... (5 entities in total)
Functional Keywordsmethyl transferase, transferase-protein binding complex, transferase/protein binding
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm : O14744
Nucleus: Q9BQA1 P62805
Total number of polymer chains3
Total formula weight116437.45
Authors
Sprague, E.R.,McNamara, J.T. (deposition date: 2015-12-10, release date: 2016-02-24, Last modification date: 2023-09-27)
Primary citationMavrakis, K.J.,McDonald, E.R.,Schlabach, M.R.,Billy, E.,Hoffman, G.R.,deWeck, A.,Ruddy, D.A.,Venkatesan, K.,Yu, J.,McAllister, G.,Stump, M.,deBeaumont, R.,Ho, S.,Yue, Y.,Liu, Y.,Yan-Neale, Y.,Yang, G.,Lin, F.,Yin, H.,Gao, H.,Kipp, D.R.,Zhao, S.,McNamara, J.T.,Sprague, E.R.,Zheng, B.,Lin, Y.,Cho, Y.S.,Gu, J.,Crawford, K.,Ciccone, D.,Vitari, A.C.,Lai, A.,Capka, V.,Hurov, K.,Porter, J.A.,Tallarico, J.,Mickanin, C.,Lees, E.,Pagliarini, R.,Keen, N.,Schmelzle, T.,Hofmann, F.,Stegmeier, F.,Sellers, W.R.
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science, 351:1208-1213, 2016
Cited by
PubMed: 26912361
DOI: 10.1126/science.aad5944
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.34 Å)
Structure validation

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