5FA5
Crystal Structure of PRMT5:MEP50 in complex with MTA and H4 peptide
Summary for 5FA5
Entry DOI | 10.2210/pdb5fa5/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4, ... (5 entities in total) |
Functional Keywords | methyl transferase, transferase-protein binding complex, transferase/protein binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : O14744 Nucleus: Q9BQA1 P62805 |
Total number of polymer chains | 3 |
Total formula weight | 116437.45 |
Authors | Sprague, E.R.,McNamara, J.T. (deposition date: 2015-12-10, release date: 2016-02-24, Last modification date: 2023-09-27) |
Primary citation | Mavrakis, K.J.,McDonald, E.R.,Schlabach, M.R.,Billy, E.,Hoffman, G.R.,deWeck, A.,Ruddy, D.A.,Venkatesan, K.,Yu, J.,McAllister, G.,Stump, M.,deBeaumont, R.,Ho, S.,Yue, Y.,Liu, Y.,Yan-Neale, Y.,Yang, G.,Lin, F.,Yin, H.,Gao, H.,Kipp, D.R.,Zhao, S.,McNamara, J.T.,Sprague, E.R.,Zheng, B.,Lin, Y.,Cho, Y.S.,Gu, J.,Crawford, K.,Ciccone, D.,Vitari, A.C.,Lai, A.,Capka, V.,Hurov, K.,Porter, J.A.,Tallarico, J.,Mickanin, C.,Lees, E.,Pagliarini, R.,Keen, N.,Schmelzle, T.,Hofmann, F.,Stegmeier, F.,Sellers, W.R. Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5. Science, 351:1208-1213, 2016 Cited by PubMed: 26912361DOI: 10.1126/science.aad5944 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
Download full validation report