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5H19

EED in complex with PRC2 allosteric inhibitor EED162

Summary for 5H19
Entry DOI10.2210/pdb5h19/pdb
Related5H13 5H14 5H15 5H17 5H24 5H25
DescriptorPolycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile, ... (4 entities in total)
Functional Keywordseed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus: O75530 Q15910
Total number of polymer chains2
Total formula weight46362.84
Authors
Zhao, K.,Zhao, M.,Luo, X.,Zhang, H. (deposition date: 2016-10-08, release date: 2017-01-25, Last modification date: 2023-11-08)
Primary citationLi, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K.
Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12:e0169855-e0169855, 2017
Cited by
PubMed: 28072869
DOI: 10.1371/journal.pone.0169855
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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