5H25
EED in complex with PRC2 allosteric inhibitor compound 11
Summary for 5H25
Entry DOI | 10.2210/pdb5h25/pdb |
Related | 5H13 5H14 5H15 5H17 5H19 5H24 |
Descriptor | Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, ... (4 entities in total) |
Functional Keywords | eed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: O75530 Q15910 |
Total number of polymer chains | 4 |
Total formula weight | 92485.41 |
Authors | |
Primary citation | Huang, Y.,Zhang, J.,Yu, Z.,Zhang, H.,Wang, Y.,Lingel, A.,Qi, W.,Gu, J.,Zhao, K.,Shultz, M.D.,Wang, L.,Fu, X.,Sun, Y.,Zhang, Q.,Jiang, X.,Zhang, J.,Zhang, C.,Li, L.,Zeng, J.,Feng, L.,Zhang, C.,Liu, Y.,Zhang, M.,Zhang, L.,Zhao, M.,Gao, Z.,Liu, X.,Fang, D.,Guo, H.,Mi, Y.,Gabriel, T.,Dillon, M.P.,Atadja, P.,Oyang, C. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem., 60:2215-2226, 2017 Cited by PubMed: 28092155DOI: 10.1021/acs.jmedchem.6b01576 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.88 Å) |
Structure validation
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