PDB: 970 件ウェブページステータス検索Chemie searchBIRD

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1DHR	CRYSTAL STRUCTURE OF RAT LIVER DIHYDROPTERIDINE REDUCTASE 分子名称: DIHYDROPTERIDINE REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Varughese, K.I, Skinner, M.M, Whiteley, J.M, Matthews, D.A, Xuong, N.H. 登録日 1992-03-30 公開日 1993-07-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of rat liver dihydropteridine reductase. Proc.Natl.Acad.Sci.USA, 89, 1992
1J3H	Crystal structure of apoenzyme cAMP-dependent protein kinase catalytic subunit 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, cAMP-dependent protein kinase, alpha-catalytic subunit 著者 Akamine, P, Madhusudan, Wu, J, Xuong, N.H, Ten Eyck, L.F, Taylor, S.S. 登録日 2003-01-31 公開日 2003-03-04 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Dynamic Features of cAMP-dependent Protein Kinase Revealed by Apoenzyme Crystal Structure J.Mol.Biol., 327, 2003
1J2E	Crystal structure of Human Dipeptidyl peptidase IV 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV 著者 Hiramatsu, H, Kyono, K, Higashiyama, Y, Fukushima, C, Shima, H, Sugiyama, S, Inaka, K, Yamamoto, A, Shimizu, R. 登録日 2002-12-30 公開日 2003-12-30 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold. Biochem.Biophys.Res.Commun., 302, 2003
4YWB	Structure of rat cytosolic pepck in complex with 3-mercaptopicolinic acid and oxalic acid 分子名称: 3-sulfanylpyridine-2-carboxylic acid, CHLORIDE ION, MANGANESE (II) ION, ... 著者 Balan, M.D, Johnson, T.A, Lotosky, W.R, Mcleod, M.J, Holyoak, T. 登録日 2015-03-20 公開日 2015-09-23 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid. Biochemistry, 54, 2015
4UBH	Resting state of rat cysteine dioxygenase Y157F variant 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (II) ION, ... 著者 Tchesnokov, E.P, Fellner, M, Jameson, G.N.L, Wilbanks, S.M. 登録日 2014-08-13 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Crystal structure of cysteine dioxygenase mutant To be published
4YYO	Resting state of rat cysteine dioxygenase C164S variant 分子名称: CHLORIDE ION, Cysteine dioxygenase type 1, FE (II) ION 著者 Fellner, M, Tchesnokov, E.P, Siakkou, E, Rutledge, M.T, Jameson, G.N.L, Wilbanks, S.M. 登録日 2015-03-24 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Influence of cysteine 164 on active site structure in rat cysteine dioxygenase. J.Biol.Inorg.Chem., 21, 2016
4UBG	Resting state of rat cysteine dioxygenase C93G variant 分子名称: Cysteine dioxygenase type 1, FE (II) ION, SODIUM ION 著者 Fellner, M, Tchesnokov, E.P, Jameson, G.N, Wilbanks, S.M. 登録日 2014-08-13 公開日 2014-11-26 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The Cys-Tyr Cross-Link of Cysteine Dioxygenase Changes the Optimal pH of the Reaction without a Structural Change. Biochemistry, 53, 2014
4Z82	Cysteine bound rat cysteine dioxygenase C164S variant at pH 8.1 分子名称: CYSTEINE, Cysteine dioxygenase type 1, FE (II) ION 著者 Fellner, M, Tchesnokov, E.P, Siakkou, E, Rutledge, M.T, Kanitz, M, Jameson, G.N.L, Wilbanks, S.M. 登録日 2015-04-08 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Influence of cysteine 164 on active site structure in rat cysteine dioxygenase. J.Biol.Inorg.Chem., 21, 2016
1W1I	Crystal structure of dipeptidyl peptidase IV (DPPIV or CD26) in complex with adenosine deaminase 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Weihofen, W.A, Liu, J, Reutter, W, Saenger, W, Fan, H. 登録日 2004-06-22 公開日 2004-09-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface. J. Biol. Chem., 279, 2004
4UJ9	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJB	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-fluorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJ1	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.768 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJ2	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-iodanylphenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.019 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4UJA	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-{(3S,4R)-4-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}quinazolin-4(3H)-one, BROMIDE ION, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-09 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
4WB8	Crystal structure of human cAMP-dependent protein kinase A (catalytic alpha subunit), exon 1 deletion 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. 登録日 2014-09-02 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
4WB7	Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ... 著者 Cheung, J, Ginter, C, Cassidy, M, Franklin, M.C, Rudolph, M.J, Hendrickson, W.A. 登録日 2014-09-02 公開日 2015-01-21 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112, 2015
4WBB	Single Turnover Autophosphorylation Cycle of the PKA RIIb Holoenzyme 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Zhang, P, Knape, M.J, Ahuja, L.G, Keshwani, M.M, King, C.C, Sastri, M, Herberg, F.W, Taylor, S.S. 登録日 2014-09-02 公開日 2015-05-20 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Single Turnover Autophosphorylation Cycle of the PKA RII beta Holoenzyme. Plos Biol., 13, 2015
1WCY	Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase IV, ... 著者 Hiramatsu, H, Yamamoto, A, Kyono, K, Higashiyama, Y, Fukushima, C, Shima, H, Sugiyama, S, Inaka, K, Shimizu, R. 登録日 2004-05-07 公開日 2005-05-07 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A Biol.Chem., 385, 2004
1X70	HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR 分子名称: (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kim, D, Wang, L, Beconi, M, Eiermann, G.J, Fisher, M.H, He, H, Hickey, G.J, Leiting, B, Lyons, K. 登録日 2004-08-12 公開日 2005-01-18 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes J.Med.Chem., 48, 2005
5BX7	PKA in complex with a benzothiophene fragment compound. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-benzothiophen-3-ylmethanol, ... 著者 Narayanan, D, Alam, K.A, Engh, R.A. 登録日 2015-06-08 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 PKA based studies of ligand interactions with a methionine gatekeeper. To Be Published
5BX6	PKA in complex with a halogenated phthalazinone fragment compound. 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-chlorophthalazin-1(2H)-one, cAMP-dependent protein kinase catalytic subunit alpha, ... 著者 Narayanan, D, Alam, K.A, Engh, R.A. 登録日 2015-06-08 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 PKA based studies of ligand interactions with a methionine gatekeeper. To Be Published
1ZPG	Arginase I covalently modified with propylamine at Q19C 分子名称: Arginase 1, MANGANESE (II) ION 著者 Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. 登録日 2005-05-16 公開日 2005-12-06 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
1ZPE	Arginase I covalently modified with butylamine at Q19C 分子名称: Arginase 1, MANGANESE (II) ION 著者 Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. 登録日 2005-05-16 公開日 2005-12-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Probing the role of the hyper-reactive histidine residue of arginase. Arch.Biochem.Biophys., 444, 2005
2ATF	X-RAY STRUCTURE OF cysteine dioxygenase type I FROM MUS MUSCULUS MM.241056 分子名称: 1,2-ETHANEDIOL, Cysteine dioxygenase type I, NICKEL (II) ION 著者 Wesenberg, G.E, Phillips Jr, G.N, Mccoy, J.G, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG) 登録日 2005-08-24 公開日 2005-10-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure and mechanism of mouse cysteine dioxygenase. Proc.Natl.Acad.Sci.Usa, 103, 2006
2AJL	X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor 分子名称: 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4 著者 Qiao, L, Baumann, C.A, Crysler, C.S, Ninan, N.S, Abad, M.C, Spurlino, J.C, DesJarlais, R.L, Kervinen, J, Neeper, M.P, Bayoumy, S.S. 登録日 2005-08-02 公開日 2005-11-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 16, 2006

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