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5BX6

PKA in complex with a halogenated phthalazinone fragment compound.

Summary for 5BX6
Entry DOI10.2210/pdb5bx6/pdb
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 4-chlorophthalazin-1(2H)-one, ... (5 entities in total)
Functional Keywordsinhibitor, protein kinase, structure-guided, fragment-based, transferase
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612
Total number of polymer chains2
Total formula weight43650.07
Authors
Narayanan, D.,Alam, K.A.,Engh, R.A. (deposition date: 2015-06-08, release date: 2016-09-14, Last modification date: 2024-01-10)
Primary citationNarayanan, D.,Gani, O.A.,Alam, K.A.,Engh, R.A.
PKA based studies of ligand interactions with a methionine gatekeeper.
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.89 Å)
Structure validation

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