4UJ9
Protein Kinase A in complex with an Inhibitor
Summary for 4UJ9
Entry DOI | 10.2210/pdb4uj9/pdb |
Related | 4UJ1 4UJ2 4UJA 4UJB |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 7-[(3S,4R)-4-[4-(trifluoromethyl)phenyl]carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, ... (5 entities in total) |
Functional Keywords | transferase, pka |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 43658.68 |
Authors | Alam, K.A.,Engh, R.A. (deposition date: 2015-04-09, release date: 2016-04-13, Last modification date: 2024-01-31) |
Primary citation | Lauber, B.S.,Hardegger, L.A.,Asraful, A.K.,Lund, B.A.,Dumele, O.,Harder, M.,Kuhn, B.,Engh, R.A.,Diederich, F. Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22:211-, 2016 Cited by PubMed: 26578105DOI: 10.1002/CHEM.201503552 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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