5FH4
| |
5FDB
| |
3Q0T
| |
3POO
| human cAMP-dependent protein kinase in complex with an inhibitor | 分子名称: | (2S,3S)-butane-2,3-diol, N'-[(E)-(2,4-dihydroxy-6-methylphenyl)methylidene]-2-(3-methoxyphenyl)acetohydrazide, cAMP-dependent protein kinase catalytic subunit alpha, ... | 著者 | Koester, H, Heine, A, Klebe, G. | 登録日 | 2010-11-23 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | fragment based drug design on PKA To be Published
|
|
3PVB
| Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase | 分子名称: | GLYCEROL, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Boettcher, A.J, Wu, J, Kim, C, Yang, J, Bruystens, J, Cheung, N, Pennypacker, J.K, Blumenthal, D.A, Kornev, A.P, Taylor, S.S. | 登録日 | 2010-12-06 | 公開日 | 2011-02-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase Structure, 19, 2011
|
|
3Q8W
| A b-aminoacyl containing thiazolidine derivative and DPPIV complex | 分子名称: | Dipeptidyl peptidase 4, N-(4-{[({(2R)-3-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-thiazolidin-2-yl}carbonyl)amino]methyl}phenyl)-D-valine | 著者 | Lee, J.O, Song, D.H. | 登録日 | 2011-01-07 | 公開日 | 2011-03-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.64 Å) | 主引用文献 | Discovery of b-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors To be Published
|
|
3QAM
| Crystal Structure of Glu208Ala mutant of catalytic subunit of cAMP-dependent protein kinase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | 著者 | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | 登録日 | 2011-01-11 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
|
|
3QBJ
| Crystal structure of dipeptidyl peptidase IV in complex with inhibitor | 分子名称: | 1-[(3S,4S)-4-amino-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-yl]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Liu, S.P. | 登録日 | 2011-01-13 | 公開日 | 2012-01-25 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Crystal structure of dipeptidyl peptidase IV in complex with inhibitor To be Published
|
|
3QAL
| Crystal Structure of Arg280Ala mutant of Catalytic subunit of cAMP-dependent Protein Kinase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein kinase inhibitor, ... | 著者 | Yang, J, Wu, J, Steichen, J, Taylor, S.S. | 登録日 | 2011-01-11 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J.Mol.Biol., 415, 2012
|
|
5I0T
| |
5I0S
| |
5I7U
| Human DPP4 in complex with a novel tricyclic hetero-cycle inhibitor | 分子名称: | 2-({2-[(3R)-3-aminopiperidin-1-yl]-5-methyl-6,9-dioxo-5,6,7,9-tetrahydro-1H-imidazo[1,2-a]purin-1-yl}methyl)-4-fluorobenzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G. | 登録日 | 2016-02-18 | 公開日 | 2016-06-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. Acs Med.Chem.Lett., 7, 2016
|
|
5I0R
| D-cysteine bound C93A mutant of Cysteine Dioxygenase at pH 8 | 分子名称: | CHLORIDE ION, Cysteine dioxygenase type 1, D-CYSTEINE, ... | 著者 | Kean, K.M, Driggers, C.M, Karplus, P.A. | 登録日 | 2016-02-04 | 公開日 | 2016-12-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428, 2016
|
|
3RLA
| |
5I0U
| |
5ISM
| Human DPP4 in complex with a novel 5,5,6-tricyclic pyrrolidine inhibitor | 分子名称: | (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)oxan-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G. | 登録日 | 2016-03-15 | 公開日 | 2016-05-11 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
|
|
5IZJ
| Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411 | 分子名称: | 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAR-DAR, 47P-AZ1-DAR-DAR-DAR, ... | 著者 | Pflug, A, Enkvist, E, Uri, A, Engh, R.A. | 登録日 | 2016-03-25 | 公開日 | 2016-07-20 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016
|
|
5IZF
| Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1408 | 分子名称: | 6J9-ZEU-DAR-ACA-DAR-NH2, SULFATE ION, cAMP-dependent protein kinase catalytic subunit alpha | 著者 | Pflug, A, Enkvist, E, Uri, A, Engh, R.A. | 登録日 | 2016-03-25 | 公開日 | 2016-07-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016
|
|
5J5X
| Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1416 | 分子名称: | 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine, 47P-AZ1-DAL-DAR-DAR-DAR-DAR, SULFATE ION, ... | 著者 | Alam, K.A, Ivan, T, Uri, A, Engh, R.A. | 登録日 | 2016-04-04 | 公開日 | 2016-07-20 | 最終更新日 | 2019-06-19 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27, 2016
|
|
5J3J
| Crystal Structure of human DPP-IV in complex with HL1 | 分子名称: | (2~{S},3~{R})-8,9-dimethoxy-3-[2,4,5-tris(fluoranyl)phenyl]-2,3-dihydro-1~{H}-benzo[f]chromen-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... | 著者 | Wu, F, Li, H, Zhao, Z, Zhu, L, Xu, H, Li, S. | 登録日 | 2016-03-31 | 公開日 | 2017-04-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal Structure of human DPP-IV in complex with HL1 To Be Published
|
|
3SWW
| Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one, ... | 著者 | Klei, H.E. | 登録日 | 2011-07-14 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3SX4
| Crystal structure of human dpp-iv in complex with sa-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)- 2-methyl-5h-pyrrolo[3,4-b]pyridin-7(6h)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyphenyl)-2-methyl-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one, ... | 著者 | Klei, H.E. | 登録日 | 2011-07-14 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site. Bioorg.Med.Chem.Lett., 21, 2011
|
|
3TNQ
| Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein kinase, ... | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | 登録日 | 2011-09-01 | 公開日 | 2012-02-01 | 最終更新日 | 2012-09-26 | 実験手法 | X-RAY DIFFRACTION (3.097 Å) | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
|
|
3TNP
| Structure and Allostery of the PKA RIIb Tetrameric Holoenzyme | 分子名称: | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type II-beta regulatory subunit | 著者 | Zhang, P, Smith-Nguyen, E.V, Keshwani, M.M, Deal, M.S, Kornev, A.P, Taylor, S.S. | 登録日 | 2011-09-01 | 公開日 | 2012-02-01 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure and allostery of the PKA RIIbeta tetrameric holoenzyme Science, 335, 2012
|
|
8UNN
| CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) | 分子名称: | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Papasergi-Scott, M.M, Skiniotis, G. | 登録日 | 2023-10-19 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 2024
|
|