5IZJ

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1411

Summary for 5IZJ

Entry DOI	10.2210/pdb5izj/pdb
Descriptor	cAMP-dependent protein kinase catalytic subunit alpha, 47P-AZ1-DAR-DAR, 47P-AZ1-DAR-DAR-DAR, ... (6 entities in total)
Functional Keywords	protein kinase, inhibitor, bisubstrate, oligoarginine, pka, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	85993.79
Authors	Pflug, A.,Enkvist, E.,Uri, A.,Engh, R.A. (deposition date: 2016-03-25, release date: 2016-07-20, Last modification date: 2019-06-19)
Primary citation	Ivan, T.,Enkvist, E.,Viira, B.,Manoharan, G.B.,Raidaru, G.,Pflug, A.,Alam, K.A.,Zaccolo, M.,Engh, R.A.,Uri, A. Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27:1900-1910, 2016 Cited by PubMed: 27389935 DOI: 10.1021/acs.bioconjchem.6b00293 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation