6QFA
| CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3, HISTAMINE, ... | 著者 | Uchanski, T, Masiulis, S, Fischer, B, Kalichuk, V, Wohlkoening, A, Zoegg, T, Remaut, H, Vranken, W, Aricescu, A.R, Pardon, E, Steyaert, J. | 登録日 | 2019-01-09 | 公開日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM. Nat.Methods, 18, 2021
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6I53
| Cryo-EM structure of the human synaptic alpha1-beta3-gamma2 GABAA receptor in complex with Megabody38 in a lipid nanodisc | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Laverty, D, Desai, R, Uchanski, T, Masiulis, S, Wojciech, J.S, Malinauskas, T, Zivanov, J, Pardon, E, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-11-12 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of the human alpha 1 beta 3 gamma 2 GABAAreceptor in a lipid bilayer. Nature, 565, 2019
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6HUO
| CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-09 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUP
| CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with diazepam (Valium), GABA and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-09 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUG
| CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with picrotoxin and megabody Mb38. | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUJ
| CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with picrotoxin, GABA and megabody Mb38. | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HUK
| CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, ... | 著者 | Masiulis, S, Desai, R, Uchanski, T, Serna Martin, I, Laverty, D, Karia, D, Malinauskas, T, Jasenko, Z, Pardon, E, Kotecha, A, Steyaert, J, Miller, K.W, Aricescu, A.R. | 登録日 | 2018-10-08 | 公開日 | 2019-01-02 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565, 2019
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6HIO
| Mouse serotonin 5-HT3 receptor, serotonin-bound, I1 conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIS
| Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation | 分子名称: | (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-INDOLE-3-CARBOXYLATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIN
| Mouse serotonin 5-HT3 receptor, serotonin-bound, F conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6HIQ
| Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | 著者 | Polovinkin, L, Neumann, E, Schoehn, G, Nury, H. | 登録日 | 2018-08-30 | 公開日 | 2018-11-07 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Conformational transitions of the serotonin 5-HT3receptor. Nature, 563, 2018
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6A96
| Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ... | 著者 | Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S. | 登録日 | 2018-07-11 | 公開日 | 2018-10-03 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor. Cell Res., 28, 2018
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6DW0
| Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (Whole map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | 登録日 | 2018-06-26 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA. Elife, 7, 2018
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6DW1
| Cryo-EM structure of the benzodiazepine-sensitive alpha1beta1gamma2S tri-heteromeric GABAA receptor in complex with GABA (ECD map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Phulera, S, Zhu, H, Yu, J, Yoshioka, C, Gouaux, E. | 登録日 | 2018-06-26 | 公開日 | 2018-08-08 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structure of the benzodiazepine-sensitive alpha 1 beta 1 gamma 2S tri-heteromeric GABAAreceptor in complex with GABA. Elife, 7, 2018
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6DG8
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6DG7
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6D6U
| Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D6T
| Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D1S
| Crystal structure of an apo chimeric human alpha1GABAA receptor | 分子名称: | chimeric alpha1GABAA receptor | 著者 | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | 登録日 | 2018-04-12 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of neurosteroid anesthetic action on GABAAreceptors. Nat Commun, 9, 2018
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6CNK
| Structure of the 3alpha2beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Walsh Jr, R.M, Roh, S.H, Gharpure, A, Morales-Perez, C.L, Hibbs, R.E. | 登録日 | 2018-03-08 | 公開日 | 2018-05-02 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor. Nature, 557, 2018
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6CNJ
| Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Walsh Jr, R.M, Roh, S.H, Gharpure, A, Morales-Perez, C.L, Teng, J, Hibbs, R.E. | 登録日 | 2018-03-08 | 公開日 | 2018-05-02 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor. Nature, 557, 2018
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6CDU
| Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone | 分子名称: | (3a,5a)-3-Hydroxypregnane-11,20-dione, chimeric alpha1GABAA receptor | 著者 | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | 登録日 | 2018-02-09 | 公開日 | 2018-08-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Structural basis of neurosteroid anesthetic action on GABAAreceptors. Nat Commun, 9, 2018
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6BE1
| Cryo-EM structure of serotonin receptor | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Basak, S, Chakrapani, S. | 登録日 | 2017-10-24 | 公開日 | 2018-02-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | 主引用文献 | Cryo-EM structure of 5-HT Nat Commun, 9, 2018
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5OSB
| GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5 | 分子名称: | ACETATE ION, CHLORIDE ION, Proton-gated ion channel,Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, ... | 著者 | Laverty, D.C, Gold, M.G, Smart, T.G. | 登録日 | 2017-08-17 | 公開日 | 2017-10-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites. Nat. Struct. Mol. Biol., 24, 2017
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5OSC
| GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5 | 分子名称: | ACETATE ION, CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Laverty, D.C, Gold, M.G, Smart, T.G. | 登録日 | 2017-08-17 | 公開日 | 2017-10-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites. Nat. Struct. Mol. Biol., 24, 2017
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