6HUK

CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with bicuculline and megabody Mb38.

Summary for 6HUK

Entry DOI	10.2210/pdb6huk/pdb
EMDB information	0280
Descriptor	Gamma-aminobutyric acid receptor subunit alpha-1,Gamma-aminobutyric acid receptor subunit alpha-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, Gamma-aminobutyric acid receptor subunit beta-3, ... (10 entities in total)
Functional Keywords	gabaar, membrane, channel, nanobody, megabody, cys-loop, plgic, inhibition, signalling, cns, neurons, chloride, ion, gaba, bcc, bicuculline, membrane protein, antagonist
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	6
Total formula weight	337221.61
Authors	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Jasenko, Z.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. (deposition date: 2018-10-08, release date: 2019-01-02, Last modification date: 2022-03-30)
Primary citation	Masiulis, S.,Desai, R.,Uchanski, T.,Serna Martin, I.,Laverty, D.,Karia, D.,Malinauskas, T.,Zivanov, J.,Pardon, E.,Kotecha, A.,Steyaert, J.,Miller, K.W.,Aricescu, A.R. GABAAreceptor signalling mechanisms revealed by structural pharmacology. Nature, 565:454-459, 2019 Cited by PubMed: 30602790 DOI: 10.1038/s41586-018-0832-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.69 Å)

Structure validation