PDB: 902 件ウェブページステータス検索Chemie searchBIRD

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6KPF	Cryo-EM structure of a class A GPCR with G protein complex 分子名称: 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Shen, L, Wang, Y.X, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6KPG	Cryo-EM structure of CB1-G protein complex 分子名称: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2020-03-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6LFM	Cryo-EM structure of a class A GPCR 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LFO	Cryo-EM structure of a class A GPCR monomer 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LI3	cryo-EM structure of GPR52-miniGs-NB35 分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Li, M, Wang, N, Xu, F, Wu, J, Lei, M. 登録日 2019-12-10 公開日 2020-02-26 最終更新日 2020-03-18 実験手法 ELECTRON MICROSCOPY (3.32 Å) 主引用文献 Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
6B3J	3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex 分子名称: Exendin-P5, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liang, Y.L, Khoshouei, M, Glukhova, A, Furness, S.G.B, Koole, C, Zhao, P, Clydesdale, L, Thal, D.M, Radjainia, M, Danev, R, Baumeister, W, Wang, M.W, Miller, L.J, Christopoulos, A, Sexton, P.M, Wootten, D. 登録日 2017-09-22 公開日 2018-02-21 最終更新日 2020-01-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature, 555, 2018
7P02	Human Neurokinin 1 receptor (NK1R) substance P Gs complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
7P00	Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex 分子名称: Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. 登録日 2021-06-29 公開日 2021-12-15 実験手法 ELECTRON MICROSCOPY (2.71 Å) 主引用文献 Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
6LML	Cryo-EM structure of the human glucagon receptor in complex with Gi1 分子名称: Glucagon, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Qiao, A, Han, S, Li, X, Sun, F, Zhao, Q, Wu, B. 登録日 2019-12-26 公開日 2020-04-01 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis of Gsand Girecognition by the human glucagon receptor. Science, 367, 2020
6B20	Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator 分子名称: CHLORIDE ION, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ... 著者 Gulati, S, Kiser, P.D, Palczewski, K. 登録日 2017-09-19 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun, 9, 2018
6LPB	Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Kobayashi, K, Shihoya, W, Nishizawa, T, Nureki, O. 登録日 2020-01-09 公開日 2020-03-11 最終更新日 2020-03-25 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein. Nat.Struct.Mol.Biol., 27, 2020
7PWD	Structure of an inhibited GRK2-G-beta and G-gamma complex 分子名称: 4-chloranyl-N-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamide, Beta-adrenergic receptor kinase 1, CHLORIDE ION, ... 著者 Faucher, N, Tauchert, M.J, Konz Makino, D.L, Vuillard, L.M. 登録日 2021-10-06 公開日 2021-10-20 最終更新日 2022-05-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthesis of thieno[2,3-c]pyridine derived GRK2 inhibitors Monatsh Chem, 2022
7PIU	Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution. 分子名称: CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. 登録日 2021-08-23 公開日 2021-11-17 実験手法 ELECTRON MICROSCOPY (2.58 Å) 主引用文献 Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
7PIV	Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. 分子名称: CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. 登録日 2021-08-23 公開日 2021-11-17 実験手法 ELECTRON MICROSCOPY (2.86 Å) 主引用文献 Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide. Cell Res., 31, 2021
6CRK	Heterotrimeric G-protein in complex with an antibody fragment 分子名称: CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Maeda, S, Dawson, R, Kobilka, B. 登録日 2018-03-19 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun, 9, 2018
6CMO	Rhodopsin-Gi complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... 著者 Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. 登録日 2018-03-05 公開日 2018-06-20 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
6C2Y	Human GRK2 in complex with Gbetagamma subunits and CCG257142 分子名称: (4R,5R,6S)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-N-(2H-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2018-01-09 公開日 2018-04-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Utilizing a structure-based docking approach to develop potent G protein-coupled receptor kinase (GRK) 2 and 5 inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
5UKM	bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as) 分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cruz-Rodriguez, O, Tesmer, J.J.G. 登録日 2017-01-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.03 Å) 主引用文献 Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60, 2017
5WG5	Human GRK2 in complex with Gbetagamma subunits and CCG224061 分子名称: 5-{[(3S,4R)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-2H-indazole, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2017-07-13 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
5WG4	Human GRK2 in complex with Gbetagamma subunits and CCG257284 分子名称: 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Bouley, R, Tesmer, J.J.G. 登録日 2017-07-13 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors. Mol. Pharmacol., 92, 2017
5UKK	Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak) 分子名称: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cato, M.C, Homan, K.T, Tesmer, J.J.G. 登録日 2017-01-23 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60, 2017
5UZ7	Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex 分子名称: Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M. 登録日 2017-02-24 公開日 2017-05-03 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546, 2017
5VAI	Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein 分子名称: Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. 登録日 2017-03-27 公開日 2017-05-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature, 546, 2017
5UKL	Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd) 分子名称: 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cato, M.C, Homan, K.T, Tesmer, J.J.G. 登録日 2017-01-23 公開日 2017-04-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60, 2017
5TDH	The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S 分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Liu, P, Jia, M.-Z, Zhou, X.E, de Waal, P.W, Dickson, B.M, Liu, B, Hou, L, Yin, Y.-T, Kang, Y.-Y, Shi, Y, Melcher, K, Xu, H.E, Jiang, Y. 登録日 2016-09-19 公開日 2016-11-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer Acta Pharmacol.Sin., 37, 2016

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