5TDH

The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S

Summary for 5TDH

• Entry DOI: 10.2210/pdb5tdh/pdb
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (4 entities in total)
• Functional Keywords: dominant negative, g-alpha(i)-1-beta-1-gamma-2 heterotrimer, g203a, a326s, gpcr, gdp, cell cycle
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P63096; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
• Total number of polymer chains: 6
• Total formula weight: 172022.18

Authors

Liu, P.,Jia, M.-Z.,Zhou, X.E.,de Waal, P.W.,Dickson, B.M.,Liu, B.,Hou, L.,Yin, Y.-T.,Kang, Y.-Y.,Shi, Y.,Melcher, K.,Xu, H.E.,Jiang, Y. (deposition date: 2016-09-19, release date: 2016-11-09, Last modification date: 2024-03-20)

• Primary citation: Liu, P.,Jia, M.-Z.,Zhou, X.E.,De Waal, P.W.,Dickson, B.M.,Liu, B.,Hou, L.,Yin, Y.-T.,Kang, Y.-Y.,Shi, Y.,Melcher, K.,Xu, H.E.,Jiang, Y.; The structural basis of the dominant negative phenotype of the G alpha i1 beta 1 gamma 2 G203A/A326S heterotrimer; Acta Pharmacol.Sin., 37:1259-1272, 2016; PubMed: 27498775; DOI: 10.1038/aps.2016.69

Experimental method

X-RAY DIFFRACTION (3 Å)