3KCK
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![BU of 3kck by Molmil](/molmil-images/mine/3kck) | A Novel Chemotype of Kinase Inhibitors | 分子名称: | 3-chloro-4-(4H-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol, Tyrosine-protein kinase JAK2 | 著者 | Zuccola, H.J, Wang, T, Ledeboer, M.W. | 登録日 | 2009-10-21 | 公開日 | 2009-11-24 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3KFA
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![BU of 3kfa by Molmil](/molmil-images/mine/3kfa) | |
3KEX
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![BU of 3kex by Molmil](/molmil-images/mine/3kex) | Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3) | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3 | 著者 | Jura, N, Shan, Y, Cao, X, Shaw, D.E, Kuriyan, J. | 登録日 | 2009-10-26 | 公開日 | 2009-12-22 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc.Natl.Acad.Sci.USA, 106, 2009
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5XD6
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![BU of 5xd6 by Molmil](/molmil-images/mine/5xd6) | CARK1 phosphorylates ABA receptors | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase superfamily protein | 著者 | Zhang, L, Lou, Z. | 登録日 | 2017-03-27 | 公開日 | 2018-04-04 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.898 Å) | 主引用文献 | CARK1 phosphorylates ABA receptors To Be Published
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5XDK
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![BU of 5xdk by Molmil](/molmil-images/mine/5xdk) | Crystal structure of EGFR 696-1022 T790M in complex with CO-1686 | 分子名称: | Epidermal growth factor receptor, N-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | 著者 | Yan, X.E, Yun, C.H. | 登録日 | 2017-03-28 | 公開日 | 2017-12-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.346 Å) | 主引用文献 | Structural basis of mutant-selectivity and drug-resistance related to CO-1686. Oncotarget, 8, 2017
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5XFF
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![BU of 5xff by Molmil](/molmil-images/mine/5xff) | |
5X5O
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![BU of 5x5o by Molmil](/molmil-images/mine/5x5o) | Crystal structure of ZAK in complex with compound D2829 | 分子名称: | Mitogen-activated protein kinase kinase kinase MLT, N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide | 著者 | Dai, Y.B, Zhao, P, Yun, C.H. | 登録日 | 2017-02-17 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.868 Å) | 主引用文献 | Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J. Med. Chem., 60, 2017
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5XGN
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![BU of 5xgn by Molmil](/molmil-images/mine/5xgn) | Crystal structure of EGFR 696-1022 T790M/C797S in complex with Go6976 | 分子名称: | 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, CHLORIDE ION, Epidermal growth factor receptor | 著者 | Kong, L.L, Yun, C.H. | 登録日 | 2017-04-14 | 公開日 | 2017-10-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural pharmacological studies on EGFR T790M/C797S. Biochem. Biophys. Res. Commun., 488, 2017
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5XP7
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![BU of 5xp7 by Molmil](/molmil-images/mine/5xp7) | C-Src in complex with ATP-CHCl | 分子名称: | GLYCEROL, MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, ... | 著者 | Guo, M, Dai, S, Duan, Y, Chen, L, Chen, Y. | 登録日 | 2017-06-01 | 公開日 | 2017-09-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.012 Å) | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases. J. Am. Chem. Soc., 139, 2017
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5XDL
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![BU of 5xdl by Molmil](/molmil-images/mine/5xdl) | |
5XYZ
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![BU of 5xyz by Molmil](/molmil-images/mine/5xyz) | The structure of human BTK kinase domain in complex with a covalent inhibitor | 分子名称: | N-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1H-1,2,4-triazol-3-yl)phenyl]propanamide, Tyrosine-protein kinase BTK | 著者 | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Xie, Y.T, Li, L, Qi, X.B, Huang, N. | 登録日 | 2017-07-11 | 公開日 | 2018-05-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery. J. Med. Chem., 60, 2017
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5Y5U
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![BU of 5y5u by Molmil](/molmil-images/mine/5y5u) | |
5YA5
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![BU of 5ya5 by Molmil](/molmil-images/mine/5ya5) | CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR | 分子名称: | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole, Hepatocyte growth factor receptor | 著者 | Liu, Q, Xu, Y. | 登録日 | 2017-08-30 | 公開日 | 2018-07-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors Eur J Med Chem, 143, 2018
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5Y25
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![BU of 5y25 by Molmil](/molmil-images/mine/5y25) | EGFR kinase domain mutant (T790M/L858R) with covalent ligand NS-062 | 分子名称: | (2R)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide, Epidermal growth factor receptor | 著者 | Shiroishi, M, Abe, Y, Caaveiro, J.M.M, Sakamoto, S, Morimoto, S, Fuchida, H, Shindo, N, Ojida, A. | 登録日 | 2017-07-24 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | 主引用文献 | Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat.Chem.Biol., 15, 2019
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5Y9T
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![BU of 5y9t by Molmil](/molmil-images/mine/5y9t) | Crystal Structure of EGFR T790M mutant in complex with naquotinib | 分子名称: | 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazin e-2-carboxamide, Epidermal growth factor receptor | 著者 | Mimasu, S, Tomimoto, Y, Maiko, I, Yasushi, A, Tatsuya, N. | 登録日 | 2017-08-28 | 公開日 | 2018-07-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, inEGFR-Mutated Non-Small Cell Lung Cancer. Mol. Cancer Ther., 17, 2018
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5XY1
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![BU of 5xy1 by Molmil](/molmil-images/mine/5xy1) | |
5Y5T
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![BU of 5y5t by Molmil](/molmil-images/mine/5y5t) | |
5YU9
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![BU of 5yu9 by Molmil](/molmil-images/mine/5yu9) | |
5ZJ6
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![BU of 5zj6 by Molmil](/molmil-images/mine/5zj6) | Crystal structure of HCK kinase complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | 分子名称: | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Tyrosine-protein kinase HCK | 著者 | Tomabechi, Y, Kukimoto-Niino, M, Shirouzu, M. | 登録日 | 2018-03-19 | 公開日 | 2018-06-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Phosphorylated and non-phosphorylated HCK kinase domains produced by cell-free protein expression. Protein Expr. Purif., 150, 2018
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5Z0S
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![BU of 5z0s by Molmil](/molmil-images/mine/5z0s) | |
5ZTO
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![BU of 5zto by Molmil](/molmil-images/mine/5zto) | Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003 | 分子名称: | CHLORIDE ION, Epidermal growth factor receptor, N-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]cyclohexyl}propanamide | 著者 | Zhu, S.J, Yun, C.H. | 登録日 | 2018-05-04 | 公開日 | 2019-06-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | 主引用文献 | Crystal structure of EGFR 696-1022 T790M/C797S in complex with D3003 To Be Published
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5ZXB
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![BU of 5zxb by Molmil](/molmil-images/mine/5zxb) | Crystal structure of ACK1 with compound 10d | 分子名称: | Activated CDC42 kinase 1, N-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | 著者 | Hong, E.M, Kim, H.L, Sim, T.B. | 登録日 | 2018-05-18 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia. J. Med. Chem., 61, 2018
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6AAJ
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![BU of 6aaj by Molmil](/molmil-images/mine/6aaj) | Crystal structure of JAK2 in complex with peficitinib | 分子名称: | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Amano, Y, Tateishi, Y. | 登録日 | 2018-07-18 | 公開日 | 2018-08-15 | 最終更新日 | 2023-03-08 | 実験手法 | X-RAY DIFFRACTION (2.37 Å) | 主引用文献 | Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor Bioorg. Med. Chem., 26, 2018
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5ZV2
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![BU of 5zv2 by Molmil](/molmil-images/mine/5zv2) | FGFR-1 in complex with ligand lenvatinib | 分子名称: | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, Fibroblast growth factor receptor 1 | 著者 | Matsuki, M, Hoshi, T, Yamamoto, Y, Ikemori-Kawada, M, Minoshima, Y, Funahashi, Y, Matsui, J. | 登録日 | 2018-05-09 | 公開日 | 2018-07-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models. Cancer Med, 7, 2018
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6AGX
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![BU of 6agx by Molmil](/molmil-images/mine/6agx) | |