3KEX

Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)

Summary for 3KEX

Entry DOI	10.2210/pdb3kex/pdb
Descriptor	Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	kinase domain, inactive kinase, her3, erbb3, atp-binding, cell membrane, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P21860
Total number of polymer chains	2
Total formula weight	73959.42
Authors	Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J. (deposition date: 2009-10-26, release date: 2009-12-22, Last modification date: 2024-04-03)
Primary citation	Jura, N.,Shan, Y.,Cao, X.,Shaw, D.E.,Kuriyan, J. Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proc.Natl.Acad.Sci.USA, 106:21608-21613, 2009 Cited by PubMed: 20007378 DOI: 10.1073/pnas.0912101106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.797 Å)

Structure validation