5Y5U
Crystal structures of spleen tyrosine kinase in complex with a novel inhibitor
Summary for 5Y5U
Entry DOI | 10.2210/pdb5y5u/pdb |
Descriptor | Tyrosine-protein kinase SYK, 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8H-pyrido[4,3-d]pyrimidin-5-one (3 entities in total) |
Functional Keywords | inhibitor, spleen tyrosine kinase, human kinase, drug discovery, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69215.65 |
Authors | |
Primary citation | Lee, S.J.,Choi, J.S.,Bong, S.M.,Hwang, H.J.,Lee, J.,Song, H.J.,Lee, J.,Kim, J.H.,Koh, J.S.,Lee, B.I. Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors. Mol. Cells, 41:545-552, 2018 Cited by PubMed: 29890824DOI: 10.14348/molcells.2018.2219 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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