8I5Y
| Structure of human Nav1.7 in complex with vixotrigine | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5B
| Structure of human Nav1.7 in complex with bupivacaine | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-24 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5G
| Structure of human Nav1.7 in complex with PF-05089771 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-25 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
8I5X
| Structure of human Nav1.7 in complex with Vinpocetine | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Wu, Q.R, Yan, N. | 登録日 | 2023-01-26 | 公開日 | 2023-06-14 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
|
|
7K48
| Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a | 著者 | Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A. | 登録日 | 2020-09-15 | 公開日 | 2020-12-02 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin. Mol.Cell, 81, 2021
|
|
7K18
| Cardiac Sodium channel with toxin bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... | 著者 | Jiang, D, Catterall, W.A. | 登録日 | 2020-09-07 | 公開日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin. Nat Commun, 12, 2021
|
|
5TJ6
| Ca2+ bound aplysia Slo1 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CALCIUM ION, High conductance calcium-activated potassium channel, ... | 著者 | MacKinnon, R, Tao, X, Hite, R.K. | 登録日 | 2016-10-03 | 公開日 | 2016-12-14 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
|
|
5TJI
| Ca2+ bound aplysia Slo1 | 分子名称: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, High conductance calcium-activated potassium channel | 著者 | MacKinnon, R, Tao, X, Hite, R.K. | 登録日 | 2016-10-04 | 公開日 | 2016-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature, 541, 2017
|
|
5VMS
| CryoEM structure of Xenopus KCNQ1 channel | 分子名称: | CALCIUM ION, Calmodulin, Potassium voltage-gated channel subfamily KQT member 1 | 著者 | Mackinnon, R, Sun, J. | 登録日 | 2017-04-28 | 公開日 | 2017-06-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. Cell, 169, 2017
|
|
5X0M
| Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, ... | 著者 | Shen, H, Zhou, Q, Pan, X, Li, Z, Wu, J, Yan, N. | 登録日 | 2017-01-21 | 公開日 | 2017-03-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355, 2017
|
|
5WO9
| |
5WO8
| |
5WOA
| |
5WP6
| Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate | 分子名称: | DECAVANADATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Winkler, P.A, Huang, Y, Sun, W, Du, J, Lu, W. | 登録日 | 2017-08-03 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Electron cryo-microscopy structure of a human TRPM4 channel. Nature, 552, 2017
|
|
5WO7
| |
5WO6
| |
6LQA
| voltage-gated sodium channel Nav1.5 with quinidine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Quinidine, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Li, Z, Pan, X, Huang, G. | 登録日 | 2020-01-13 | 公開日 | 2021-03-24 | 最終更新日 | 2021-05-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Na v 1.5 by the Antiarrhythmic Drug Quinidine*. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
6MJ2
| Human TRPM2 ion channel in a calcium- and ADPR-bound state | 分子名称: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2 | 著者 | Wang, L, Fu, T.M, Xia, S, Wu, H. | 登録日 | 2018-09-20 | 公開日 | 2018-12-12 | 最終更新日 | 2019-01-02 | 実験手法 | ELECTRON MICROSCOPY (6.36 Å) | 主引用文献 | Structures and gating mechanism of human TRPM2. Science, 362, 2018
|
|
6MU2
| Structure of full-length IP3R1 channel in the Apo-state | 分子名称: | Inositol 1,4,5-trisphosphate receptor type 1 | 著者 | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | 登録日 | 2018-10-22 | 公開日 | 2018-12-05 | 最終更新日 | 2019-11-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
|
|
6MIX
| |
6MIZ
| |
6NT3
| Cryo-EM structure of a human-cockroach hybrid Nav channel. | 分子名称: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Clairfeuille, T, Rohou, A, Payandeh, J. | 登録日 | 2019-01-28 | 公開日 | 2019-02-20 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. Science, 2019
|
|
6ND0
| |
6NT4
| Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. | 分子名称: | (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Clairfeuille, T, Rohou, A, Payandeh, J. | 登録日 | 2019-01-28 | 公開日 | 2019-02-20 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of alpha-scorpion toxin action on Na v channels. Science, 363, 2019
|
|
6MU1
| Structure of full-length IP3R1 channel bound with Adenophostin A | 分子名称: | Adenophostin A, Inositol 1,4,5-trisphosphate receptor type 1 | 著者 | Serysheva, I.I, Fan, G, Baker, M.R, Wang, Z, Seryshev, A, Ludtke, S.J, Baker, M.L. | 登録日 | 2018-10-22 | 公開日 | 2018-12-05 | 最終更新日 | 2019-11-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM reveals ligand induced allostery underlying InsP3R channel gating. Cell Res., 28, 2018
|
|